Angina landscape shifting towards increased recognition of microvascular angina in clinical practice

Microvascular angina (MVA) is being increasingly recognized in clinical practice, says GlobalData, a leading data and analytics company.

According to key opinion leaders (KOLs) interviewed by GlobalData, patients with exertional angina and symptoms strongly suggestive of coronary artery disease (CAD) were previously often disregarded since the diagnosis of chronic stable angina was highly related to the presence of atherosclerotic obstructions. As this condition’s pathogenesis remained uncertain it was labeled as ‘cardiac syndrome X’. However, in the last few years, the landscape is shifting with an increasing number of physicians accepting the notion that a dysfunctional microvasculature is the cause of angina in some patients.

Kelly Lambrinos, Senior Pharma Analyst at GlobalData, comments: “Experts further highlighted that a knowledge gap still exists in understanding microvascular syndromes, coronary microvascular dysfunction in particular, and treatment strategies that are particularly targeting the microvascular dysfunction are lacking.”

Efforts towards understanding the pathophysiological mechanisms underpinning MVA are of paramount importance in the process of developing therapies that optimally treat these patients.

Lambrinos adds: “Currently, standard anti-anginal drugs such as beta-blockers, calcium channel blockers and nitrates offer some relief from symptoms. Despite the availability of these therapies, however, KOLs interviewed by GlobalData highlight that a significant need remains in the current treatment paradigm for additional agents that target the specific heterogeneous pathogenesis of MVA.”

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