Asthma and Chronic Obstructive Pulmonary Disease: Asthma Ahead of COPD in Terms of Innovation with the Focus on Targeted Biologic Therapies for Severe Disease Phenotypes

Asthma and COPD are both highly prevalent, chronic, inflammatory diseases of the airways and lungs. The asthma market is highly saturated with relatively efficacious standard therapies and the COPD market is also highly saturated with therapies that help to prevent exacerbations of the disease. However, there is considerable unmet need for innovative new therapies for severe asthmatics who do not respond to the current standards of care, and treatments which can reverse the progression of COPD. This report assesses first-in-class innovation across the asthma and COPD pipelines.

Scope

Both the asthma and COPD markets are highly saturated. Which drug classes are used to treat these disorders? How do the drug classes in the market compare with those in the pipelines?

There are 266 and 161 pipeline programs in active development for asthma and COPD, respectively. What proportion of these products are first-in-class? How does first-in-class innovation vary by indication, development stage and molecular target class?

Which molecular target classes are prominently represented in the first-in-class asthma and COPD pipelines? Which first-in-class targets have been identified as most promising for asthma and COPD, and is there any overlap?

Which companies are the key players within the asthma and COPD markets? Who has been involved in the most licensing and co-development deals for asthma and COPD products? Which first-in-class products have prior deal involvement?

Reasons to buy

Understand the current disease landscape with an overview of etiology, pathophysiology, disease classification and staging systems, epidemiology, and treatment options for both asthma and COPD.

Visualize the composition of the asthma and COPD markets in terms of dominant molecule types and molecular targets. This allows an understanding of any gaps in the current market.

Analyze and compare the asthma and COPD pipelines and stratify by stage of development, molecule type, and molecular target.

Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class products for each indication have been assessed and ranked according to clinical potential. Promising first-in-class targets have been reviewed in greater detail.

Recognize commercial opportunities by identifying first-in-class asthma and COPD pipeline products that have not yet been involved in licensing or co-development deals, and by analyzing company strategies in prior deals through case studies of key deals for asthma and COPD first-in-class products.

Table of Contents

1 Table of Contents

1.1 List of Tables

1.2 List of Figures

2 Asthma and COPD: Executive Summary

2.1 COPD Lagging Behind ...

1 Table of Contents

1.1 List of Tables

1.2 List of Figures

2 Asthma and COPD: Executive Summary

2.1 COPD Lagging Behind Asthma in Terms of Innovation

2.2 Innovation in Asthma Pipeline is Focused Towards Targeted Biologic Therapies for Severe Phenotypes of the Disease

2.3 FIC Innovation in COPD Pipeline is Concentrated at the Early Development Stages

3 Introduction

3.1 Catalyst

3.2 Related Reports

3.3 Upcoming Related Reports

4 Disease Overview

4.1 Etiology and Pathophysiology

4.1.1 Asthma

4.1.2 COPD

4.2 Classification or Staging Systems

4.2.1 Asthma

4.2.2 COPD

4.3 Sustained Innovation in Asthma and COPD

4.4 Epidemiology for Asthma and COPD

4.5 Overview for Marketed Products

5 Assessment of Pipeline Product Innovation

5.1 Overview

5.2 Pipeline by Stage of Development and Molecule Type

5.2.1 Asthma

5.2.2 COPD

5.3 Pipeline by Molecular Target

5.3.1 Asthma

5.3.2 COPD

5.4 Comparative Distribution of Programs Between the Market and Pipeline by Molecular Target Class

5.4.1 Asthma

5.4.2 COPD

5.5 Comparative Distribution of First-in-Class and Non-First-in-Class Pipeline Programs by Molecular Target Class

5.5.1 Asthma

5.5.2 COPD

5.6 Ratio of First-in-Class Programs to First-in-Class Molecular Target within the Pipeline

5.6.1 Asthma

5.6.2 COPD

6 First-in-Class Molecular Target Evaluation

6.1 Overview

6.2 Asthma

6.2.1 Pipeline Programs Targeting [Identified Target #1]

6.2.2 Pipeline Programs Targeting [Identified Target #2]

6.2.3 Pipeline Programs Targeting [Identified Target #3]

6.2.4 Pipeline Programs Targeting [Identified Target #4]

6.3 COPD

6.3.1 Pipeline Programs Targeting [Identified Target #1]

6.3.2 Pipeline Programs Targeting [Identified Target #2]

6.3.3 Pipeline Programs Targeting [Identified Target #3]

6.4 Asthma and COPD

6.4.1 Pipeline Programs Targeting [Identified Target #1]

6.4.2 Pipeline Programs Targeting [Identified Target #2]

7 Key Players and Deals

7.1 Overview

7.1.1 Regeneron and Sanofi Sign Co-Development Deal for Multiple Pipeline Assets

7.1.2 GlaxoSmithKline Enters Licensing Deal with Janssen to Expand Respiratory Offering

7.1.3 Amgen and AstraZeneca Co-development Deal for Several Monoclonal Antibodies

8 Appendix

8.1 Bibliography

8.2 Abbreviations

8.3 Methodology

8.3.1 Market Analysis

8.3.2 Overall Pipeline Analysis

8.3.3 First-in-Class Pipeline Analysis

8.3.4 First-in-Class Matrix Assessment

8.3.5 First-in-Class Molecular Target Evaluation

8.3.6 Key Players and Deals

8.4 About the Authors

8.4.1 Analyst

8.4.2 Therapy Area Director

8.4.3 Global Director of Therapy Analysis and Epidemiology

8.4.4 Global Head and EVP of Healthcare Operations and Strategy

8.5 About GlobalData

8.6 Contact Us

8.7 Disclaimer

List of Tables

Table 1: Risk Factors for Asthma

Table 2: Risk Factors for COPD

Table 3: Classification of Asthma by Severity

Table 4: GOLD 2017 Assessment of ...

Table 1: Risk Factors for Asthma

Table 2: Risk Factors for COPD

Table 3: Classification of Asthma by Severity

Table 4: GOLD 2017 Assessment of Airflow Limitation in COPD

Table 5: GOLD 2017 Assessment of Symptoms/Risk of Exacerbations in COPD

Table 6: Asthma’s Diagnosed Prevalent Cases (Millions), 2013–2023

Table 7: COPD’s Diagnosed Prevalent Cases (Millions), 2015–2025

List of Figures

Figure 1: Global Asthma Market by Molecular Target and Molecule Type, 2019

Figure 2: Global COPD Market by Molecular Target and Molecule Type, 2019

Figure ...

Figure 1: Global Asthma Market by Molecular Target and Molecule Type, 2019

Figure 2: Global COPD Market by Molecular Target and Molecule Type, 2019

Figure 3: Asthma, Global, Pipeline by Stage of Development and Molecule Type, 2019

Figure 4: COPD, Global, Pipeline by Stage of Development and Molecule Type, 2019

Figure 5: Asthma, Global, Pipeline by Molecular Target and Stage of Development, 2019

Figure 6: COPD, Global, Pipeline by Molecular Target and Stage of Development, 2019

Figure 7: Asthma, Global, Distribution of Pipeline and Marketed Products by Molecular Target Class, 2019

Figure 8: COPD, Global, Distribution of Pipeline and Marketed Products by Molecular Target Class, 2019

Figure 9: Asthma, Global, Distribution of Pipeline Products by First-in-Class Status and Molecular Target Class, 2019

Figure 10: Asthma, Global, Percentage Distribution of First-in-Class and Non-First-in-Class Products by Stage of Development and Molecular Target Class, 2019

Figure 11: COPD, Global, Distribution of Pipeline Products by First-in-Class Status and Molecular Target Class, 2019

Figure 12: COPD, Global, Percentage Distribution of First-in-Class and Non-First-in-Class Products by Stage of Development and Molecular Target Class, 2019

Figure 13: Asthma, Global, Ratio of First-in-Class and Non-First-in-Class Products to First-in-Class Targets by Stage of Development and Molecular Target Class, 2019

Figure 14: COPD, Global, Ratio of First-in-Class and Non-First-in-Class Products to First-in-Class Targets by Stage of Development and Molecular Target Class, 2019

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