KOL Perspectives: Perceptions of recent & upcoming data for key HBV pipeline agents

Pages: 28 Published: October 30, 2018 Report Code: GDHC053SP

Questions topics:
› Further Phase I data required for Roche’s capsid inhibitor RO7049389
› Replicor’s US trial plans and transition from IV to subcutaneous REP 2139
› Efficacy of Spring Bank’s inarigivir at 100mg in the Phase II ACHIEVE trial
› Expected role for inarigivir in HBV
› Efficacy of Arbutus’s Q2W IV ARB-1467
› ARB-1467, TDF + Peg-IFN trial design, potential for functional cure, & regimen acceptability
› Future development of Arbutus’s next-generation RNAi therapeutic AB-729For internal use only


› The insight briefing is based on Sociable Pharma’s analysis of primary research with our HBV key opinion leaders (KOLs)

› In total, we conducted interviews with 10 KOLs:

– 5 Europe-based & 5 N. America-based

– Interviews performed during Sept 2018

> KOL data is analyzed to produce:

– Charts summarizing KOL opinions

– Chart call-outs of key information & details

– KOL quotes

– Summary of KOL reporting trends

– Insight from Sociable Pharma's analysts

Key Highlights

Divided views on most relevant Phase I data required to differentiate RO7049389 from JNJ-6379 & ABI-H0731, with most concluding that Phase I data is insufficien

KOLs agree Replicor is making positive steps towards REP 2139’s development, but similar efficacy & safety must be demonstrated in the US trials and for the SC formulation

Disagreement between US and EU KOLs over the improvement in efficacy of inarigivir at the 100mg dose

Reasons to Buy

Combines Qualitative & semi-quantitative insight from key opinion leaders on "recent & upcoming data for key HBV pipeline agents"

Includes insight & recommendations from our disease-specific healthcare analysts

Utilizes independent expert viewpoints to validate the impact of new clinical data & emerging trends on management of HBV

Provides cost-effective support for your advisory boards, with topics acting as a catalyst for further expert discussion

Key Players

Spring Bank

Table of Contents

Table of Contents

Executive Summary


Research Panel Composition

Results & Implications



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