Prosthetic Joint Infections Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

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PJI Pipeline Products Market Report Overview

Prosthetic joint infection (PJI) is one of the most serious complications of prosthetic joint implantation. Symptoms include pain or stiffness in joints, swelling, redness around the wound, fatigue, and fever. Risk factors include age, prior arthroplasty, poor nutritional status, obesity, diabetes mellitus, and advanced HIV disease. Treatment includes antimicrobial therapy.

The PJI pipeline market research report provides comprehensive information on the therapeutics under development for PJI, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history, and the latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for PJI and features dormant and discontinued projects.

PJI Pipeline Products Market Segmentation by Targets

The key targets in the PJI pipeline products market are Bacterial Cell Wall, 16S Ribosomal RNA, ATP Dependent Clp Protease Proteolytic Subunit Mitochondrial, DNA Gyrase, DNA Topoisomerase IV, RNA Polymerase, and Staphylococcus aureus Bifunctional Autolysin. The Bacterial Cell Wall is the leading target in the pipeline.

PJI Pipeline Products Market Analysis by Targets

PJI Pipeline Products Market Analysis by TargetsFor more target insights into the PJI pipeline products market, download a free report sample

PJI Pipeline Products Market Segmentation by Mechanisms of Action

The key mechanisms of action in the PJI pipeline products market are Bacterial Cell Wall Disruptor, 16S Ribosomal RNA Inhibitor, ATP Dependent Clp Protease Proteolytic Subunit Mitochondrial Activator, DNA Gyrase Inhibitor, DNA Topoisomerase IV Inhibitor, RNA Polymerase Inhibitor, and Staphylococcus aureus Bifunctional Autolysin Inhibitor. Bacterial Cell Wall Disruptor is the leading MoA in the pipeline market.

PJI Pipeline Products Market Analysis by Mechanisms of Action

PJI Pipeline Products Market Analysis by Mechanisms of ActionFor more mechanisms of action insights into the PJI pipeline products market, download a free report sample

PJI Pipeline Products Market Segmentation by Routes of Administration

The key routes of administration in the PJI pipeline products market are intravenous, intraarticular, parenteral, oral, and topical. Intravenous is the leading RoA.

PJI Pipeline Products Market Analysis by Routes of Administration

PJI Pipeline Products Market Analysis by Routes of AdministrationFor more routes of administration insights into the PJI pipeline products market, download a free report sample

PJI Pipeline Products Market Segmentation by Molecule Types

The key molecule types in the PJI pipeline products market are biologic, small molecule, recombinant enzyme, monoclonal antibody, and synthetic peptide. Biologic is the leading molecule type.

PJI Pipeline Products Market Analysis by Molecule Types

PJI Pipeline Products Market Analysis by Molecule TypesFor more molecule type insights into the PJI pipeline products market, download a free report sample

PJI Pipeline Products Market - Competitive Landscape

Some of the leading companies in the PJI pipeline products market are ContraFect Corp, Adaptive Phage Therapeutics Inc, Arietis Corp, Armata Pharmaceuticals Inc, Integrated BioTherapeutics Inc, Lumobiotics GmbH, Osteal Therapeutics Inc, Peptilogics Inc, and Pherecydes Pharma SA among others. ContraFect Corp is the leading company in the PJI pipeline products market.

PJI Pipeline Products Market Analysis by Companies

PJI Pipeline Products Market Analysis by CompaniesTo know more about the leading players in the PJI pipeline products market, download a free report sample

PJI Pipeline Products Market Report Overview

Key Targets Bacterial Cell Wall, 16S Ribosomal RNA, ATP Dependent Clp Protease Proteolytic Subunit Mitochondrial, DNA Gyrase, DNA Topoisomerase IV, RNA Polymerase, and Staphylococcus aureus Bifunctional Autolysin
Key Mechanisms of Action Bacterial Cell Wall Disruptor, 16S Ribosomal RNA Inhibitor, ATP Dependent Clp Protease Proteolytic Subunit Mitochondrial Activator, DNA Gyrase Inhibitor, DNA Topoisomerase IV Inhibitor, RNA Polymerase Inhibitor, and Staphylococcus aureus Bifunctional Autolysin Inhibitor
Key Routes of Administration Intravenous, Intraarticular, Parenteral, Oral, and Topical
Key Molecule Type Biologic, Small Molecule, Recombinant Enzyme, Monoclonal Antibody, and Synthetic Peptide
Leading Companies ContraFect Corp, Adaptive Phage Therapeutics Inc, Arietis Corp, Armata Pharmaceuticals Inc, Integrated BioTherapeutics Inc, Lumobiotics GmbH, Osteal Therapeutics Inc, Peptilogics Inc, and Pherecydes Pharma SA

Scope

  • The pipeline guide provides a snapshot of the global therapeutic landscape of PJI.
  • The pipeline guide reviews pipeline therapeutics for PJI by companies and universities/research institutes based on information derived from company and industry-specific sources.
  • The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration to discovery and undisclosed stages.
  • The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
  • The pipeline guide reviews key companies involved in PJI therapeutics and enlists all their major and minor projects.
  • The pipeline guide evaluates PJI therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA), and molecule type.
  • The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
  • The pipeline guide reviews the latest news related to pipeline therapeutics for PJI

Reasons to Buy

  • Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
  • Recognize emerging players with potentially strong product portfolios and create effective counter-strategies to gain competitive advantage.
  • Find and recognize significant and varied types of therapeutics under development for PJI.
  • Classify potential new clients or partners in the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying key players and their most promising pipeline therapeutics.
  • Formulate corrective measures for pipeline projects by understanding the PJI pipeline depth and focus of Indication therapeutics.
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
  • Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from the pipeline.

Adaptive Phage Therapeutics Inc
Arietis Corp
Armata Pharmaceuticals Inc
ContraFect Corp
Integrated BioTherapeutics Inc
Lumobiotics GmbH
Osteal Therapeutics Inc
Peptilogics Inc
Pherecydes Pharma SA
Qentoros Inc
Sonoran Biosciences Inc
TenNor Therapeutics Ltd

Table of Contents

Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Prosthetic Joint infections – Overview

Prosthetic Joint infections – Therapeutics Development

Pipeline Overview

Pipeline by Companies

Products under Development by Companies

Prosthetic Joint infections – Therapeutics Assessment

Assessment by Target

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Prosthetic Joint infections – Companies Involved in Therapeutics Development

Adaptive Phage Therapeutics Inc

Arietis Corp

Armata Pharmaceuticals Inc

ContraFect Corp

Integrated BioTherapeutics Inc

Lumobiotics GmbH

Osteal Therapeutics Inc

Peptilogics Inc

Pherecydes Pharma SA

Qentoros Inc

Sonoran Biosciences Inc

TenNor Therapeutics Ltd

Prosthetic Joint infections – Drug Profiles

(tobramycin + vancomycin SR) – Drug Profile

Product Description

Mechanism Of Action

A-103 – Drug Profile

Product Description

Mechanism Of Action

APSA-02 – Drug Profile

Product Description

Mechanism Of Action

BIO-PLY – Drug Profile

Product Description

Mechanism Of Action

CF-296 – Drug Profile

Product Description

Mechanism Of Action

exebacase – Drug Profile

Product Description

Mechanism Of Action

PLG-0206 – Drug Profile

Product Description

Mechanism Of Action

PP-2351 – Drug Profile

Product Description

Mechanism Of Action

Prosthetic Joint Infection (PJI) – Drug Profile

Product Description

Mechanism Of Action

Small Molecule to Activate CIPP for Prosthetic Joint Infections – Drug Profile

Product Description

Mechanism Of Action

Small Molecules for Oncology and Infectious Disease – Drug Profile

Product Description

Mechanism Of Action

TNP-2092 – Drug Profile

Product Description

Mechanism Of Action

TPH-101 – Drug Profile

Product Description

Mechanism Of Action

Prosthetic Joint infections – Dormant Projects

Prosthetic Joint infections – Discontinued Products

Prosthetic Joint infections – Product Development Milestones

Featured News & Press Releases

Nov 29, 2022: Pherecydes Pharma announces the positive recommendation of the DSMB for the continuation of its phase II clinical study PhagoDAIR in osteoarticular infections caused by staphylococcus aureus

Nov 28, 2022: ContraFect announces ANSM approval of clinical trial application for exebacase in prosthetic joint infections

Oct 20, 2022: Peptilogics to present data at IDWeek 2022 on PLG0206, an engineered antimicrobial peptide targeting bacteria causing periprosthetic joint infection

Oct 07, 2022: Peptilogics doses first subject in periprosthetic joint infection trial

Sep 12, 2022: ContraFect announces presentation of new clinical data from a study using exebacase in the LysinDAIR procedure on patients with chronic knee prosthetic joint infection

Aug 06, 2022: Peptilogics to participate in Musculoskeletal Infection Society (MSIS) 32nd Annual Open Scientific Meeting in Pittsburgh

Aug 01, 2022: Armata Pharmaceuticals announces clearance of IND for prosthetic joint infections

Jul 19, 2022: Peptilogics receives FDA fast track designation for PLG0206, an investigational peptide therapeutic in development for the treatment of periprosthetic joint infection

Apr 19, 2022: Peptilogics to present data highlighting designed antimicrobial peptide for the treatment of Periprosthetic Joint Infection (PJI) at ECCMID 2022

Mar 22, 2022: Peptilogics’ Presentations at American Academy of Orthopedic Surgeons (AAOS) 2022 Annual Meeting highlight peptide therapeutic PLG0206 for the treatment of periprosthetic joint infection (PJI)

Jan 10, 2022: Peptilogics announces FDA clearance of investigational new drug application to initiate clinical trial of PLG0206 in periprosthetic joint infection

Dec 01, 2021: Peptilogics announces two peer-reviewed publications on designed peptide therapeutic PLG0206 for periprosthetic joint infection

Sep 29, 2021: Peptilogics presents positive first-in-human phase 1 data for its lead engineered antibacterial peptide, PLG0206, at IDWeek 2021

Sep 22, 2021: Peptilogics to present first-in-human phase 1 clinical data of PLG0206 at IDWeek 2021

May 26, 2021: ContraFect announces multiple publications on exebacase, including first manuscript on local administration of lysin for potential treatment of prosthetic joint infections

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

Table

List of Tables

Number of Products under Development for Prosthetic Joint infections, 2022

Number of Products under Development by Companies, 2022

Products under Development by Companies, 2022

Number of Products by Stage and Target, 2022

Number of Products by Stage and Mechanism of Action, 2022

Number of Products by Stage and Route of Administration, 2022

Number of Products by Stage and Molecule Type, 2022

Prosthetic Joint infections – Pipeline by Adaptive Phage Therapeutics Inc, 2022

Prosthetic Joint infections – Pipeline by Arietis Corp, 2022

Prosthetic Joint infections – Pipeline by Armata Pharmaceuticals Inc, 2022

Prosthetic Joint infections – Pipeline by ContraFect Corp, 2022

Prosthetic Joint infections – Pipeline by Integrated BioTherapeutics Inc, 2022

Prosthetic Joint infections – Pipeline by Lumobiotics GmbH, 2022

Prosthetic Joint infections – Pipeline by Osteal Therapeutics Inc, 2022

Prosthetic Joint infections – Pipeline by Peptilogics Inc, 2022

Prosthetic Joint infections – Pipeline by Pherecydes Pharma SA, 2022

Prosthetic Joint infections – Pipeline by Qentoros Inc, 2022

Prosthetic Joint infections – Pipeline by Sonoran Biosciences Inc, 2022

Prosthetic Joint infections – Pipeline by TenNor Therapeutics Ltd, 2022

Prosthetic Joint infections – Dormant Projects, 2022

Prosthetic Joint infections – Discontinued Products, 2022

Figures

List of Figures

Number of Products under Development for Prosthetic Joint infections, 2022

Number of Products under Development by Companies, 2022

Number of Products by Top 10 Targets, 2022

Number of Products by Stage and Top 10 Targets, 2022

Number of Products by Top 10 Mechanism of Actions, 2022

Number of Products by Stage and Top 10 Mechanism of Actions, 2022

Number of Products by Top 10 Routes of Administration, 2022

Number of Products by Stage and Top 10 Routes of Administration, 2022

Number of Products by Top 10 Molecule Types, 2022

Number of Products by Stage and Top 10 Molecule Types, 2022

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