Net Present Value Model: Tazverik
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Overview
Evaluating the value of drugs is a complicated practice and requires a deep knowledge of the drug itself, the market currently and in the future, knowledge of cash inflows and outflows and the potential success rates for each stage of drug development. GlobalData has done all of this work for you, leveraging its gold standard Drugs Intelligence database to create high-value NPV models for purchase on a drug-by-drug basis.
Drug Operating Profit Model
Tazverik Drug Details
Tazemetostat hydrobromide (Tazverik) is an anti-neoplastic agent. It is formulated as film coated tablets for oral route of administration. Tazverik is indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection, for adult patients with relapsed or refractory (R/R) follicular lymphoma (FL) whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test and who have received at least 2 prior systemic therapies, and for adult patients with R/R FL who have no satisfactory alternative treatment options. Tazemetostat hydrobromide is under development for the treatment of pancreatic cancer, colorectal cancer, recurrent or metastatic head and neck squamous-cell carcinoma, marginal zone lymphoma, non-Hodgkin lymphoma, mantle cell lymphoma, metastatic castration-resistant prostate cancer, b-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, chordoma, primary mediastinal B-cell lymphoma (EZH2), other relapsed or refractory solid tumors such as INI1-negative tumors including malignant rhabdoid tumor (MRT), rhabdoid tumor of the kidney (RTK), atypical teratoid / rhabdoid tumor (ATRT), epithelioid malignant peripheral nerve sheath tumor, neuroblastoma, extraskeletal myxoid chondrosarcoma, myoepithelial carcinoma, hepatocellular carcinoma, squamous non-small cell lung cancer, relapsed or refractory mesothelioma (pleural, peritoneal, pericardial, tunica vaginalis), renal medullary carcinoma, urothelial carcinoma, small-cell lung cancer and 3 unspecified indications. The drug candidate is administered orally. It is a selective small molecule inhibitor of protein methyltransferase EZH2. It was also under development for chronic myeloid leukaemia, endometrial cancer, ovarian cancer, peritoneal cancer and uterine cancer. It was also under development for the treatment of synovial sarcoma, rhabdomyosarcoma, hematological tumor, Non-Hodgkin lymphoma, solid tumor and lymphoma.
Report Coverage
GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
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Reasons to Buy
- Better understand the quantitative value of a specific drug
- Create or support internal NPV models to improve accuracy
- Understand the profit a drug is expected to make, taking into account revenue and cost forecasts leveraging public and proprietary data sets.
Frequently asked questions
- All drug sales and forecasts within NPV Model are calculated in our proprietary company based models . In these models, Analyst Consensus forecasts are built by using company-specific broker reports to create the sales forecasts for each Drug and Segment.
- Sales and forecasts are not indication-specific where drugs are approved , or in development, for multiple indications. Please refer to GlobalData’s Disease Analysis reports for indication-specific sales forecasts.
- Risk-adjusted NPVs use GlobalData’s LoA and PTSR for the indication in the highest development stage. Please refer to the Likelihood of Approval methodology for more details on this content.
GlobalData’s NPV Model is a premium model providing a fully-interactive forecasting and valuation tool, driven by Analyst Consensus estimates, enabling users to analyze and customize valuations for pharmaceutical assets including drugs or segments. The tool provides 17-year drug forecasts from companies with sales forecast data in the pharmaceutical industry, including established global firms and emerging biotechs, which allows access to critical information to facilitate strategic decision making around pharmaceutical assets
The NPV Model includes a forecasted Revenue Model, followed by a proprietary Patent Expiry Model, Operating Profit Model, Net Profit (apply Tax rate) and Discounted Cash Flow (apply Discount rates), to derive Net Present Value (NPV) for a chosen pharmaceutical asset
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