1 Table of Contents
|1 Table of Contents 3
|1.1 List of Tables 6
|1.2 List of Figures 7
2 Introduction 8
2.1 What Is This Report About? 8
2.2 Spinal Surgery Market Segmentation 8
2.3 Definitions of Markets Covered in the Report 9
3 Spinal Surgery Market, United States 13
3.1 Spinal Surgery Market, United States, Revenue ($m), 2015-2025 13
3.1.1 Minimal Invasive Spinal Devices Market, United States, Revenue ($m), by Segment, 2015-2025 16
3.1.2 Spinal Fusion Market, United States, Revenue ($m), by Segment, 2015-2025 18
3.1.3 Spinal Non-Fusion Market, United States, Revenue ($m), by Segment, 2015-2025 20
3.1.4 Vertebral Body Replacement Systems Market, United States, Revenue ($m), by Segment, 2015-2025 23
3.1.5 Vertebral Compression Fracture Repair Devices Market, United States, Revenue ($m), by Segment, 2015-2025 25
3.2 Spinal Surgery Market, United States, Volume (Units), 2015-2025 27
3.2.1 Minimal Invasive Spinal Devices Market, United States, Volume (Units), by Segment, 2015-2025 30
3.2.2 Spinal Fusion Market, United States, Volume (Units), by Segment, 2015-2025 32
3.2.3 Spinal Non-Fusion Market, United States, Volume (Units), by Segment, 2015-2025 34
3.2.4 Vertebral Body Replacement Systems Market, United States, Volume (Units), by Segment, 2015-2025 37
3.2.5 Vertebral Compression Fracture Repair Devices Market, United States, Volume (Units), by Segment, 2015-2025 39
3.3 Spinal Surgery Market, United States, Average Price ($) , 2015-2025 41
3.4 Spinal Surgery Market, United States, Distribution Share by Revenue ($m), 2019 45
3.5 Spinal Surgery Market, United States, Company Share by Revenue ($m), 2019 46
4 Overview of Key Companies in United States, Spinal Surgery Market 48
4.1 Medtronic Plc 48
4.1.1 Company Overview 48
4.2 DePuy Synthes Inc 48
4.2.1 Company Overview 48
4.3 Stryker Corp 48
4.3.1 Company Overview 48
4.4 NuVasive Inc 49
4.4.1 Company Overview 49
4.5 Globus Medical Inc 49
4.5.1 Company Overview 49
4.6 Zimmer Biomet Holdings Inc 49
4.6.1 Company Overview 49
5 Spinal Surgery Market Pipeline Products 50
6 Financial Deals Landscape 52
6.1 Acquisition 52
6.1.1 Pantheon Spinal Acquires Incite Innovation 52
6.2 Debt Offerings 53
6.2.1 Stryker Prices USD600 Million in Public Offering of
0.600% Senior Notes Due 2023 53
6.2.2 CryoLife Prices Private Placement of
4.250% Notes Due 2025 for USD100 Million 54
6.2.3 NuVasive Raises USD450 Million in Private Placement of 1% Convertible Senior Notes Due 2023 56
6.2.4 Stryker Raises USD650 Million in Public Offering of
1.15% Notes Due 2025 58
6.2.5 Stryker Raises USD1 Billion in Public Offering of
1.95% Notes Due 2030 60
6.2.6 Stryker Raises USD650 Million in Public Offering of
2.9% Notes Due 2050 62
6.2.7 Zimmer Biomet Prices Public Offering of
3.55% Notes Due 2030 for USD900 Million 64
6.2.8 Zimmer Biomet Prices Public Offering of
3.05% Notes Due 2026 for USD600 Million 66
6.2.9 NuVasive Prices Private Placement of
0.375% Notes Due 2025 for USD450 Million 68
6.3 Equity Offerings 70
6.3.1 InVivo Therapeutics Raises USD15 Million in Public Offering of Shares and Warrants 70
6.3.2 Alphatec Holdings Raises USD115 Million in Public Offering of Shares 72
6.3.3 Spinal Elements to Raise up to USD115.5 Million in IPO of Shares 74
6.3.4 SINTX Technologies Plans to Raise up to USD75 Million in Public Offering of Securities 76
6.3.5 CryoLife Raises USD20 Million in Equity Financing 77
6.3.6 SINTX Technologies to Raise USD8.19 Million in Public Offering of Shares 78
6.3.7 SINTX Technologies Prices Private Placement of Shares for USD3 Million 79
6.3.8 SINTX Technologies to Raise USD41.3 Million in Public offering of Shares 80
6.3.9 SINTX Technologies Prices Private Placement of Shares for USD5.6 Million 82
6.3.10 OrthoPediatrics Raises USD75.2 Million in Public Offering of Shares 83
6.3.11 InVivo Therapeutics Raises USD3 Million in Private Placement of Shares 85
6.3.12 InVivo Therapeutics Raises USD7 Million in Public Offering of Shares and Warrants 86
6.3.13 DiscGenics to Raise Funds through Private Placement 88
6.3.14 SANUWAVE Health Raises USD2.25 Million in Private Placement of Series C Convertible Preferred Stock 89
6.3.15 Aurora Spine Raises USD0.2 Million in Equity Offering 90
6.3.16 Sintx Technologies to Raise USD8.8 million in Rights Offering 91
6.4 Grants 93
6.4.1 Novel Test of Infant Hearing 93
6.4.2 IND-enabling preclinical development of a system for the multipurpose prevention of HIV and unintended pregnancy 94
6.5 Partnerships 95
6.5.1 Orthofix Medical and Neo Medical Enter into Partnership 95
6.6 Private Equity 96
6.6.1 Alphatec to Raise USD138 Million in Private Placement of Common Stock 96
6.6.2 MiMedx to Raise USD100 Million in Private Equity Financing 98
6.7 Venture Financing 100
6.7.1 ReGelTec Raises USD3.75 Million in Venture Funding 100
6.7.2 DiscGenics Raises USD4 Million in Series A Financing 101
6.7.3 DiscGenics Raises USD50 Million in Series C Financing 102
7 Recent Developments 104
7.1 Corporate Communications 104
7.1.1 Mar 03, 2020: Ocular Therapeutix Provides update on interim data from the OTX-TKI Phase 1 clinical trial at the Cowen 40th Annual Health Care Conference 104
7.1.2 Mar 02, 2020: Stryker announces new Investor Relations leader 105
7.1.3 Feb 25, 2020: Stryker announces nomination of new Director, Lisa Skeete Tatum 105
7.1.4 Feb 10, 2020: Roche’s gantenerumab fails in Phase II/III inherited Alzheimer’s trial 106
7.1.5 Jan 24, 2020: Cardinal Health: Departure of directors or certain officers; election of directors; appointment of certain officers; compensatory arrangements of certain officers 106
7.2 Financial Announcements 107
7.2.1 Feb 20, 2020: LX Analyzer successfully detects Coronavirus RNA 107
7.2.2 Feb 19, 2020: Integra LifeSciences reports fourth quarter and full-year 2019 financial results and provides 2020 financial guidance 108
7.2.3 Feb 13, 2020: CryoLife reports fourth quarter and full year 2019 financial results 109
7.2.4 Feb 06, 2020: Cardinal Health reports second quarter results for fiscal year 2020 110
7.2.5 Feb 04, 2020: Zimmer Biomet announces fourth quarter and full-year 2019 financial results 111
7.2.6 Jan 28, 2020: Beckman Coulter's Access PCT Procalcitonin Assay receives U.S. FDA 510(k) clearance 112
7.2.7 Jan 28, 2020: Stryker reports 2019 results and 2020 outlook 112
7.3 Government and Public Interest 113
7.3.1 Nov 18, 2020: OnPoint Surgical to participate in Canaccord Genuity Virtual MedTech & Diagnostics Forum 113
7.3.2 Aug 27, 2020: SANUWAVE Health to Participate in Upcoming September Investor Conferences 114
7.4 Legal And Regulatory 114
7.4.1 Apr 06, 2020: MiMedx Group agrees to pay $6.5 million to resolve false claims act allegations of false commercial pricing disclosures 114
7.4.2 Mar 05, 2020: U.S. Attorney sues spinal device company and its executives for allegations that they paid kickbacks to surgeons 115
7.4.3 Mar 05, 2020: DOJ files suit against spine device manufacturer and executives alleging kickbacks to surgeons through sham consulting payments 116
7.4.4 Feb 14, 2020: SpineGuard initiates safeguard proceedings while adapting its governance to strengthen the development of innovation 117
7.5 Other Significant Developments 118
7.5.1 Aug 11, 2020: ICM Brain and Spine Institute selects Western Digital OpenFlex solution to speed up time to discovery of critical cures and treatment options 118
7.5.2 Aug 03, 2020: Hyaluronic acid provides knee oa pain relief with lower costs, fewer adverse outcomes vs. corticosteroids or knee arthroplasty 119
7.5.3 Jun 29, 2020: DePuy Synthes renews cooperation agreement with AO Foundation to continue advancement of surgical education 120
7.5.4 May 28, 2020: Conformis announces settlement of patent dispute 120
7.5.5 Mar 04, 2020: CytoDyn treats first patient with Leronlimab in Phase 2 trial for GvHD under modified trial protocol 120
7.6 Product News 121
7.6.1 Dec 15, 2020: HSS bone study sheds light on complications after spinal surgery 121
7.6.2 Oct 06, 2020: ATEC announces commercial release of distinct, comprehensive TLIF approach 122
7.6.3 Oct 05, 2020: Aurora Spine’s patent related to DEXA technology patient-matched implant technology issued by the United States Patent Office 123
7.6.4 Aug 26, 2020: Promimic’s business partner launches unique 3D-printed implants following FDA approval 124
7.6.5 Jun 18, 2020: Spinal Elements lunches platform to reduce spine surgery consequences 124
7.6.6 Jun 17, 2020: Spinal Elements introduces its MIS Ultra platform of products and procedures designed to minimize the unintended consequences of spine surgery 124
7.6.7 Jun 15, 2020: Study finds similar short-term outcomes after two common minimally invasive spine procedures 125
7.6.8 Apr 27, 2020: SpineGuard strengthens its IP with the grant of three new patents 126
7.7 Strategy And Business Planning 126
7.7.1 Jan 15, 2021: OrthoPediatrics expands its agent network in three strategic European countries 126
7.7.2 Aug 06, 2020: WishBone Medical acquires two firms to expand sterile spine product range 127
7.7.3 Jan 27, 2020: Spine Care Technologies and Zober Industries announce Strategic Alliance 127
8 Appendix 128
8.1 Research Methodology 129
8.1.1 Coverage 129
8.1.2 Secondary Research 129
8.1.3 Primary Research 130
8.1.4 Market Modeling and Forecasting 131
8.1.5 Company Share Analysis 132
8.1.6 Distribution Share Analysis 133
8.1.7 Benchmarking 133
8.2 GlobalData Consulting 133
8.3 Contact Us 134
8.4 Disclaimer 134
