Diabetic Neuropathic Pain Market Size, Drug Analysis, Epidemiology, Disease Management, Pipeline Assessment, Unmet Needs and Forecast 2031

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Diabetic Neuropathic Pain Market Report Overview

The DNP market size across the 7MM was valued at $1.7 billion in 2021 and will achieve a CAGR of more than 2% during 2021-2031. The large prevalent population of patients with DNP, the high cost of drugs, and the number of drugs marketed exclusively in the US compared to other countries in the 7MM will drive market growth during the forecast period.

Diabetic Neuropathic Pain Market Outlook, 2021-2031 ($ Billion)

Diabetic Neuropathic Pain Market Outlook, 2021-2031 ($ Billion)

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The DNP market research covers the 7MM (France, Germany, Italy, Spain, and the UK) and provides a forecast model for the DNP market through 2031.

Market Size (2021) $1.7 billion
CAGR (2021-2031) >2%
Key Class of Drugs ·       Gabapentinoids

·       Tricyclic Antidepressants

·       Sodium Channel Blockers

·       Opioids

·       Tropical Analgesics

Leading Players ·       Viatris

·       Grunenthal

·       Eli Lilly

·       Helixmith Co

·       Glenmark Pharmaceuticals

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Diabetic Neuropathic Pain Market Insights

The ACOT of pipeline products is significantly higher when compared with the cost of generic analgesic therapies for DNP. This may restrict uptake with payers and physicians preferring to prescribe cheaper alternatives, when possible, thereby restricting the market growth. However, a total of four new pipeline products will launch, each of which will have a higher annual cost of therapy when compared with the cost of the most used analgesics, which are highly genericized. This, in turn, will positively impact the market growth during the forecast period.

Diabetic Neuropathic Pain - Treatment Insights

  • In cases where patients have mild DNP and their daily functioning or QoL is not affected, pharmacological treatment is not required, as the side effects associated with the current treatment may outweigh their analgesic benefits.
  • The availability of many inexpensive generics makes the DNP market competitive and crowded. Meta-analyses have been conducted to compare the efficacy of these products and there is little to differentiate the first-line treatments in terms of efficacy for the treatment of DNP and other neuropathic pain disorders.
  • A curative or disease-modifying therapy is highly sought in DNP while available treatments for the management of DNP allow for symptomatic relief.

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Diabetic Neuropathic Pain Market Segmentation by Class of Drugs

In 2021, the gabapentinoids were the top-selling class of drugs in the DNP market

A few of the key classes of drugs in the global DNP market are gabapentinoids, tricyclic antidepressants, sodium channel blockers, opioids, and tropical analgesics.

Diabetic Neuropathic Pain Market Analysis by Class of Drugs, 2021 (%)

Diabetic Neuropathic Pain Market Analysis by Class of Drugs, 2021 (%)

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Diabetic Neuropathic Pain Market - Competitive Landscape

A few of the leading players in the Diabetic Neuropathic Pain market are:

  • Viatris
  • Grunenthal
  • Eli Lilly
  • Helixmith Co
  • Glenmark Pharmaceuticals

Of the late-stage pipeline products that are being developed for the treatment of DNP, Helixmith’s Engensis seems to be the most promising with the highest clinical score and commercial score. This is attributed to its unique MOA, which is a gene therapy that has demonstrated potential disease-modifying properties.

Diabetic Neuropathic Pain Market Analysis by Companies

Diabetic Neuropathic Pain Market Analysis by Companies

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Scope

This report provides:

  • Overview of Diabetic Neuropathic Pain, including epidemiology, symptoms, diagnosis, and disease management.
  • Annualized Diabetic Neuropathic Pain market revenue, cost of therapy per patient, and treatment usage patterns forecast from 2021 to 2031.
  • Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping, and implications of these factors for the Diabetic Neuropathic Pain therapeutics market.
  • Comprehensive data assessing emerging trends and mechanisms of action under development for Diabetic Neuropathic Pain treatment. The most promising candidates in Phase III and Phase IIb development are profiled.
  • Analysis of the current and future market competition in the global Diabetic Neuropathic Pain therapeutics market. Insightful review of the key industry drivers, restraints, and challenges. Each trend is independently researched to provide a qualitative analysis of its implications.

Reasons to Buy

  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
  • Develop business strategies by understanding the trends shaping and driving the 7MM Diabetic Neuropathic Pain therapeutics market.
  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the 7MM Diabetic Neuropathic Pain therapeutics market in the future.
  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
  • Identify emerging players with potentially strong product portfolios and create effective counterstrategies to gain a competitive advantage.
  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships.

AstraZeneca
Boehringer Ingelheim
Daiichi Sankyo Co
Eli Lilly
GlaxoSmithKline
Glenmark Pharmaceuticals
Grunenthal
Helixmith Co
Lexicon Pharmaceuticals
Mitsubishi Tanabe Pharma Corp
Mundipharma
Novaremed AG
Novartis
Ono Pharmaceutical Co
Pfizer
Regenacy Pharmaceuticals
Sun Pharmaceutical Industries
UCB
Viatris

Table of Contents

  • 1 Diabetic Neuropathic Pain: Executive Summary

    • 1.1 DNP market will grow to $3.0 billion
    • 1.2 Key players will struggle to maintain their competitive position
    • 1.3 While outlook in DNP improves, opportunities remain to improve patient outcomes
    • 1.4 Novel late-stage pipeline drugs will be a key driver of growth
    • 1.5 What do physicians think?

  • 2 Introduction

    • 2.1 Catalyst
    • 2.2 Related reports
    • 2.3 Upcoming reports

  • 3 Disease Overview

    • 3.1 Etiology and pathophysiology

      • 3.1.1 Etiology
      • 3.1.2 Pathophysiology

    • 3.2 Classification or staging systems

  • 4 Epidemiology

    • 4.1 Disease background
    • 4.2 Risk factors and comorbidities
    • 4.3 Global and historical trends
    • 4.4 7MM forecast methodology

      • 4.4.1 Sources used
      • 4.4.2 Forecast assumptions and methods
      • 4.4.3 Total prevalent cases of DNP
      • 4.4.4 Diagnosed prevalent cases of DNP
      • 4.4.5 Diagnosed prevalent cases of DNP by DSPN and non-DSPN
      • 4.4.6 p-DPN among diagnosed prevalent cases of T1D and T2D

    • 4.5 Epidemiological forecast for total prevalent cases of DNP (2021–31)

      • 4.5.1 Total prevalent cases of DNP
      • 4.5.2 Age-specific total prevalent cases of DNP
      • 4.5.3 Sex-specific total prevalent cases of DNP
      • 4.5.4 Diagnosed prevalent cases of DNP
      • 4.5.5 Diagnosed prevalent cases of DNP by DSPN and Non-DSPN
      • 4.5.6 p-DPN among diagnosed prevalent cases of T1D and T2D

    • 4.6 Discussion

      • 4.6.1 Epidemiological forecast insight
      • 4.6.2 COVID-19 impact
      • 4.6.3 Limitations of the analysis
      • 4.6.4 Strengths of the analysis

  • 5 Disease Management

    • 5.1 Diagnosis overview
    • 5.2 Treatment overview
    • 5.3 Other KOL insights on disease management

  • 6 Competitive Assessment

    • 6.1 Overview

  • 7 Unmet Needs and Opportunity Assessment

    • 7.1 Overview
    • 7.2 Development of therapies with an improved efficacy profile
    • 7.3 Development of therapies with improved safety and tolerability profile
    • 7.4 Development of a curative or disease-modifying agent
    • 7.5 Improving physician and public recognition of DNP

  • 8 R&D Strategies

    • 8.1 Overview

      • 8.1.1 Development of analgesics with novel MOAs
      • 8.1.2 Patient stratification

    • 8.2 Clinical trials design

      • 8.2.1 Clinical endpoints
      • 8.2.2 High failure rate in DNP clinical trials
      • 8.2.3 Patient recruitment

  • 9 Pipeline Assessment

    • 9.1 Overview
    • 9.2 Promising drugs in clinical development

  • 10 Pipeline Valuation Analysis

    • 10.1 Overview
    • 10.2 Competitive assessment

  • 11 Current and Future Players

    • 11.1 Overview
    • 11.2 Deal-making trends

  • 12 Market Outlook

    • 12.1 Global markets

      • 12.1.1 Forecast
      • 12.1.2 Drivers and barriers – global issues

    • 12.2 US

      • 12.2.1 Forecast
      • 12.2.2 Key events
      • 12.2.3 Drivers and barriers

    • 12.3 5EU

      • 12.3.1 Forecast
      • 12.3.2 Key events
      • 12.3.3 Drivers and barriers

    • 12.4 Japan

      • 12.4.1 Forecast
      • 12.4.2 Key events
      • 12.4.3 Drivers and barriers

  • 13 Appendix

    • 13.1 Bibliography
    • 13.2 Abbreviations
    • 13.3 Methodology

      • 13.3.1 Forecasting methodology

    • 13.4 Primary research – KOLs interviewed for this report

      • 13.4.1 KOLs

    • 13.5 Primary research – prescriber survey
    • 13.6 About the Authors

      • 13.6.1 Analyst
      • 13.6.2 Therapy Area Director
      • 13.6.3 Epidemiologist
      • 13.6.4 Managing Epidemiologist
      • 13.6.5 Vice President of Disease Analysis and Intelligence
      • 13.6.6 Global Head and EVP of Healthcare Operations and Strategy

  • 14 Contact Us

Table

| List of Tables

Table 1: DNP: key metrics in the 7MM

Table 2: Classification of diabetic neuropathies

Table 3: Risk factors and comorbid conditions associated with DNP

Table 4: Treatment Guidelines for DNP

Table 5: DNP market – global drivers and barriers, 2021–2031

Table 6: Key events impacting sales for DNP in the US, 2021–2031

Table 7: DNP market – drivers and barriers in the US, 2021–2031

Table 8: Key events impacting sales for DNP in the 5EU, 2021–2031

Table 9: DNP market – drivers and barriers in the 5EU, 2021–2031

Table 10: Key events impacting sales for DNP in Japan, 2021–2031

Table 11: DNP market – drivers and barriers in Japan, 2021–2031

Table 12: High-prescribing physicians (non-KOLs) surveyed, by country

Figures

| List of Figures

Figure 1: Global sales forecast by country for DNP in 2021 and 2031

Figure 2: Analysis of the company portfolio gap in DNP during the forecast period

Figure 3: Competitive assessment of the pipeline drugs benchmarked against the SOC, Lyrica (pregabalin)

Figure 4: Pain pathway – somatosensory system

Figure 5: The pathogenesis of diabetic neuropathy is multifactorial

Figure 6: 7MM, total prevalence of DNP (%), men and women, ages ≥20 years, 2021

Figure 7: 7MM, diagnosed prevalence of DNP (%), men and women, ages ≥20 years, 2021

Figure 8: Case flow map

Figure 9: 7MM, sources used to forecast the total prevalent cases of DNP

Figure 10: 7MM, sources used to forecast the diagnosed prevalent cases of DNP

Figure 11: 7MM, sources used to forecast the diagnosed prevalent cases of DNP by DSPN and non-DSPN

Figure 12: 7MM, sources used to forecast p-DPN by T1D and T2D

Figure 13: 7MM, total prevalent cases of DNP, N, men and women, ages ≥20 years, 2021

Figure 14: 7MM, total prevalent cases of DNP by age, N, men and women, 2021

Figure 15: 7MM, total prevalent cases of DNP by sex, N, ages ≥20 years, 2021

Figure 16: 7MM, diagnosed prevalent cases of DNP, N, men and women, ages ≥20 years, 2021

Figure 17: 7MM, diagnosed prevalent cases of DNP by DSPN and non-DSPN, N, men and women, ages ≥20 years, 2021

Figure 18: 7MM, p-DPN among diagnosed prevalent cases of T1D and T2D, N, men and women, ages ≥20 years, 2021

Figure 19: General treatment algorithm for DNP

Figure 20: Unmet needs and opportunities in DNP

Figure 21: Overview of the development pipeline in DNP

Figure 22: Key late-stage trials for the promising pipeline agents that GlobalData expects be licensed for DNP in the 7MM during the forecast period

Figure 23: Competitive assessment of the pipeline drugs benchmarked against the SOC, Lyrica (pregabalin)

Figure 24: Analysis of the company portfolio gap in DNP during the forecast period

Figure 25: Global (7MM) sales forecast by country for DNP in 2021 and 2031

Figure 26: Sales forecast by class for DNP in the 7MM in 2021 and 2031

Figure 27: Sales forecast by class for DNP in the US in 2021 and 2031

Figure 28: Sales forecast by class for DNP in the 5EU in 2021 and 2031

Figure 29: Sales forecast by class for DNP in Japan in 2021 and 2031

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