Geographic Atrophy – Drugs In Development, 2024

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Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD), a progressive eye condition affecting the macula, the central part of the retina responsible for detailed central vision. GA specifically refers to a severe and advanced stage of dry AMD. GA is characterized by the gradual degeneration and death of cells in the macula, leading to the formation of sharply defined, well-demarcated areas of atrophy or cell loss. These areas appear as “geographic” patches of damaged retina, giving the condition its name. GA primarily affects central vision, impairing the ability to see fine details, read, drive, or recognize faces. The peripheral vision is typically preserved until later stages of the disease. Symptoms may include blurry or distorted central vision, decreased contrast sensitivity, and difficulty adapting to changes in lighting conditions. Diagnosis of geographic atrophy is typically based on a comprehensive eye examination, including retinal imaging such as optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging. Risk factors include advanced age, family history of AMD, smoking, and certain genetic factors.

The Geographic Atrophy drugs in development market research report provide comprehensive information on the therapeutics under development for Geographic Atrophy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also covers the descriptive pharmacological action and product description of the therapeutics, and the latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Geographic Atrophy and features dormant and discontinued products.

Note:

* This is an “on-demand” report and will be delivered within 2 business days (excluding weekends and holidays) of the purchase.

* Certain sections in the report may be removed or altered based on the availability and relevance of data.

Quick View – Geographic Atrophy
Key Targets
· Complement C5; Complement Factor D; Complement C3; Complement Factor H; Complement Factor I; Complement Factor B; Retinol Binding Protein 4; Voltage Dependent Anion Selective Channel Protein 1; Tumor Necrosis Factor Receptor Superfamily Member 6; and Leukotriene B4
Key Mechanisms of Action
· Complement C5 Inhibitor; Complement Factor D Inhibitor; Complement C3 Inhibitor; Complement Factor I Activator; Complement Factor B Inhibitor; Voltage Dependent Anion Selective Channel Protein 1 Blocker; Retinol Binding Protein 4 Inhibitor; Serotransferrin Activator; Serine Protease HTRA Inhibitor; and Serine/Threonine Protein Kinase Sgk2 Activator
Key Routes of Administration
· Intravitreal; Oral; Intraocular; Subcutaneous; Ophthalmic; Intravenous; Topical; Inhalational; and Parenteral
Key Molecule Types
· Small Molecule; Gene Therapy; Monoclonal Antibody; Cell Therapy; Synthetic Peptide; Antisense RNAi Oligonucleotide; Recombinant Protein; Antisense Oligonucleotide; Aptamer; and Antibody
Major Companies
· Alexion Pharmaceuticals Inc; Boehringer Ingelheim International GmbH; Apellis Pharmaceuticals Inc; Adverum Biotechnologies Inc; NovelMed Therapeutics Inc; F. Hoffmann-La Roche Ltd; Eyevensys SAS; Inflammasome Therapeutics Inc; Tamarix Pharma Ltd; and Stealth BioTherapeutics Inc.

Scope

  • Therapeutics in Development: Covering 62 molecules, with 60 developed by companies and the rest by universities/institutes.
  • Analysis Parameters: Offering insights by stage of development, drug target, MoA, RoA, and molecule type for a comprehensive overview.
  • Pharmacological Insights: Understand the descriptive pharmacological action of therapeutics.
  • Development History: Access the complete research and development history.
  • Latest News and Press Releases: Stay updated with the latest developments through comprehensive news coverage.

Reasons to Buy

  • Holistic insights: Understand the broad spectrum of Geographic Atrophy therapeutics, aiding strategic decision-making with insights into stages, targets, MoA, RoA and molecule types.
  • Pipeline Exploration: Explore the detailed Geographic Atrophy pipeline, offering nuanced analysis of drug targets, mechanisms of action and routes of administration for varied decision-making.
  • Comprehensive R&D: Access thorough R&D histories, providing a comprehensive understanding of Geographic Atrophy treatments for adaptable decision-making.
  • Save valuable hours: Identify key players steering innovation in therapeutics, enabling strategic partnerships.

Key Players

4D Molecular Therapeutics Inc
Adverum Biotechnologies Inc
Akari Therapeutics Plc
Aldeyra Therapeutics Inc
Alexion Pharmaceuticals Inc
Alkeus Pharmaceuticals Inc
Alzheon Inc
Annexon Inc
Apellis Pharmaceuticals Inc
Astellas Pharma Inc
Aviceda Therapeutics Inc
Belite Bio Inc
Boehringer Ingelheim International GmbH
CalciMedica Inc
CIRC Biosciences Inc
Cognition Therapeutics Inc
Complement Therapeutics Ltd
Curative Biotechnology Inc
Disc Medicine Inc
Endogena Therapeutics Inc
Eye Co Pty Ltd
Eyevensys SAS
F. Hoffmann-La Roche Ltd
GenSight Biologics SA
Gyroscope Therapeutics Holdings Ltd
Ikarovec Ltd
Inflammasome Therapeutics Inc
IVERIC bio Inc
Johnson & Johnson
Kriya Therapeutics Inc
Laboratoires Thea SA
Lan-yi Therapeutics Ltd
National Eye Institute
Neuroptika Inc
Novartis AG
NovelMed Therapeutics Inc
Oculis Holding AG
Oculogenex Inc
OliX Pharmaceuticals Inc
ONL Therapeutics Inc
Opsis Therapeutics LLC
Perfuse Therapeutics Inc
Rallybio Corp
Ray Therapeutics Inc
Retrotope Inc
Stealth BioTherapeutics Inc.
Stuart Therapeutics Inc
U.S. National Institutes of Health
Visgenx Inc
Visus Therapeutics Inc

Table of Contents

Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Overview

Therapeutics Development

Pipeline Overview

Pipeline by Companies

Pipeline by Universities/Institutes

Drugs Under Development by Companies

Drugs under Development by Universities/Institutes

Therapeutics Assessment

Assessment by Target

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Companies Involved in Therapeutic Development

Drug Profiles

Dormant Projects

Discontinued Drugs

Product Development Milestones

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

Table

List of Tables

Number of Drugs under Development, 2024

Number of Drugs under Development by Companies, 2024

Number of Drugs under Development by Universities/Institutes, 2024

Drugs under Development by Companies, 2024

Drugs under Development by Universities/Institutes, 2024

Number of Drugs by Stage and Target, 2024

Number of Drugs by Stage and Mechanism of Action, 2024

Number of Drugs by Stage and Route of Administration, 2024

Number of Drugs by Stage and Molecule Type, 2024

Dormant Projects, 2024

Discontinued Drugs, 2024

Figures

List of Figures

Number of Drugs under Development, 2024

Number of Drugs under Development by Companies, 2024

Number of Drugs under Development by Universities/Institutes, 2024

Number of Drugs by Top 10 Targets, 2024

Number of Drugs by Stage and Top 10 Targets, 2024

Number of Drugs by Top 10 Mechanism of Actions, 2024

Number of Drugs by Stage and Top 10 Mechanism of Actions, 2024

Number of Drugs by Top 10 Routes of Administration, 2024

Number of Drugs by Stage and Top 10 Routes of Administration, 2024

Number of Drugs by Top 10 Molecule Types, 2024

Number of Drugs by Stage and Top 10 Molecule Types, 2024

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