Net Present Value Model: Lenvima
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Overview
Evaluating the value of drugs is a complicated practice and requires a deep knowledge of the drug itself, the market currently and in the future, knowledge of cash inflows and outflows and the potential success rates for each stage of drug development. GlobalData has done all of this work for you, leveraging its gold standard Drugs Intelligence database to create high-value NPV models for purchase on a drug-by-drug basis.
Drug Operating Profit Model

Lenvima Drug Details
Lenvatinib mesylate (Lenvima/ Kisplyx) is a pyrrolopyrimidine derivative acts as anti-neoplastic agent. It is formulated as hard gelatin capsules for oral route of administration. Lenvima is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer (DTC). Lenvima is indicated for the treatment of adult patients with progressive, locally advanced or metastatic, differentioated (papillary, follicular, Hurthel cell) thyroid carcinoma refractory to radioactive iodine and Kisplyx is indicated in combination with everolimus for the treatment of patients with advanced renal cell carcinoma following one prior anti-angiogenic therapy and for the treatment of adult patients with advanced renal cell carcinoma following one prior vascular endothelial growth factor (VEGF) targeted therapy and indicated for the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). Lenvima is indicated for the treatment of unresectable thymic carcinoma and also indicated in combination with pembrolizumab for the first-line treatment of adult patients with advanced renal cell carcinoma.It is also under development for the treatment of advanced adrenocortical cancer, malignant pleural mesothelioma, advanced/metastatic gastric cancer, metastatic esophageal squamous cell carcinoma, gastroesophageal junction adenocarcinoma, melanoma, recurrent or metastatic head and neck squamous cell carcinoma of oral cavity, oropharynx, hypopharynx, and/or larynx, locally advanced or metastatic gastrointestinal Stromal Tumor (GIST), pediatric diffuse intrinsic pontine glioma, recurrent or metastaticsalivary gland cancers, anaplastic thyroid cancer, merkel cell carcinoma, pancreatic ductal adenocarcinoma, relapsed and refractory osteosarcoma, Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), rhabdomyosarcoma, high grade glioma, breast cancer, triple-negative breast cancer, endometrial cancer, renal cell carcinoma (second line), hepatocellular carcinoma, bladder cancer, locally advanced or metastatic non-squamous non-small cell lung cancer, endometrial cancer, urothelial cancer, biliary tract cancer, advanced gastric cancer, adenoid cystic carcinoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer (RET translocations), thymic carcinoma, endometrial cancer, fallopian tube cancer, peritoneal cancer, recurrent head and neck cancer squamous cell carcinoma, colorectal cancer, cutaneous squamous cell carcinoma and epithelial ovarian cancer, ampullary carcinoma, gallbladder carcinoma, prostate cancer and mixed carcinoma. It is also under development for solid tumors in combination with pembrolizumab. It is also under development in combination with everolimus for the treatment of advanced or metastatic non clear cell renal cell carcinoma who have not received any chemotherapy for advanced disease. It was also under development for recurrent malignant glioma, liver fibrosis, endometrial cancer (monotherapy), melanoma and recurrent glioblastoma, metastatic melanoma and non-small cell lung cancer (third-line, monotherapy). It is under development for the treatment of human papillomavirus (HPV)-associated recurrent respiratory papillomatosis (RRP). It is under development for the treatment of leptomeningeal metastases from any solid tumor.It was under development for the treatment of non-small cell lung cancer, lung adenocarcinoma,.
Report Coverage
GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
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Reasons to Buy
- Better understand the quantitative value of a specific drug
- Create or support internal NPV models to improve accuracy
- Understand the profit a drug is expected to make, taking into account revenue and cost forecasts leveraging public and proprietary data sets.
Frequently asked questions
- All drug sales and forecasts within NPV Model are calculated in our proprietary company based models . In these models, Analyst Consensus forecasts are built by using company-specific broker reports to create the sales forecasts for each Drug and Segment.
- Sales and forecasts are not indication-specific where drugs are approved , or in development, for multiple indications. Please refer to GlobalData’s Disease Analysis reports for indication-specific sales forecasts.
- Risk-adjusted NPVs use GlobalData’s LoA and PTSR for the indication in the highest development stage. Please refer to the Likelihood of Approval methodology for more details on this content.
GlobalData’s NPV Model is a premium model providing a fully-interactive forecasting and valuation tool, driven by Analyst Consensus estimates, enabling users to analyze and customize valuations for pharmaceutical assets including drugs or segments. The tool provides 17-year drug forecasts from companies with sales forecast data in the pharmaceutical industry, including established global firms and emerging biotechs, which allows access to critical information to facilitate strategic decision making around pharmaceutical assets
The NPV Model includes a forecasted Revenue Model, followed by a proprietary Patent Expiry Model, Operating Profit Model, Net Profit (apply Tax rate) and Discounted Cash Flow (apply Discount rates), to derive Net Present Value (NPV) for a chosen pharmaceutical asset
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