Likelihood of Approval and Phase Transition Success Rate Model – Loncastuximab Tesirine in Burkitt Lymphoma
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This report provides you with the data that allows you to track and predict the specific likelihood of approval (LOA) and phase transition success rate (PTSR) of a drug using GlobalData’s proprietary machine learning algorithms developed using over 10 years of historical data.


Loncastuximab Tesirine in Burkitt Lymphoma Drug Details:
Loncastuximab Tesirine (Zynlonta) is a CD19-directed antibody and alkylating agent conjugate, consisting of a humanized IgG1 kappa monoclonal antibody conjugated to SG3199, a pyrrolobenzodiazepine (PBD) dimer cytotoxic alkylating agent .It is formulated as lyophilized powder for solution for intravenous route of administration. Zynlonta is indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, high-grade B-cell lymphoma, and B-cell non-Hodgkin Lymphoma.loncastuximab tesirine (ADCT-402) is under development for the treatment of B-cell non-hodgkin lymphoma including Burkitt lymphoma, chronic lymphocytic leukemia (CLL), marginal zone B-cell lymphoma, extranodal marginal zone b-cell lymphoma, splenic marginal zone b-cell lymphoma, Waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma), lymphadenopathy or splenomegaly, relapsed and refractory diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. The therapeutic candidate is administered intravenously. The drug candidate is an antibody drug conjugate consists of a monoclonal antibody combined to pyrrolobenzodiazepines (PBD) based warheads. The drug candidate targets CD19. The warheads are developed using pyrrolobenzodiazepines (PBDs) technology. It was under development for primary mediastinal large B-cell lymphoma, relapsed or refractory B-cell acute lymphocytic leukemia.
Report Coverage
The data is segmented by drug name per indication and shows the current likelihood of approval for the drug compared to the indication benchmark and the industry benchmark.
The Likelihood of Approval data is updated regularly based on events that take place which impact the clinical development process and regulatory considerations. GlobalData’s proprietary machine learning models consider these events in real time, to produce quantitative changes to the LOA and PTSR along with qualitative reasoning why the likelihood of approval has changed.
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Reasons to Buy
- Precise Likelihood of Approval and Phase Transition Success Rates: Our machine learning and proprietary models provide accurate predictions, helping you gauge the potential success of a drug in the regulatory process.
- Competitive Strategy Planning: Access information on LOA and PTSR for competitors’ drugs, allowing you to plan your clinical development, commercialisation and marketing strategies
- Event-driven Updates: Track event-driven changes in LOA and PTSR benchmarked against indication LOA/PTSR. Get the latest insights to adapt your strategies promptly!
- Well-informed Investment Decisions: This data helps you navigate the dynamic landscape of drug development and regulatory considerations.
Scope
- Drug Details: Drug name, Drug type, Intervention type
- Administration Pathway
- Therapeutic Areas
- Key Manufacturers
- Drug Development Status
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