Clinical Trials – Impact of COVID-19 and Long COVID

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Long Covid Clinical Trials Analysis Report Overview

This report provides an overview of global COVID-19 clinical trials, long COVID clinical trials, and trialsĀ disrupted by COVID-19.

Scope

The clinical trials data used for these analyses were extracted from GlobalDataā€™s Clinical Trials Database. The data was captured in the database as of April 12, 2023. The data was analyzed and segmented by COVID-19 trials, COVID-19 trials for vaccines and therapeutics, and long COVID trials. An analysis was also completed on non-COVID trials impacted due to the pandemic.

Reasons to Buy

Trends of COVID-19 trials through the years

Comparison of trials by phase, sponsor type and status

Geographic analysis

Focus on top sponsors for vaccine and therapeutic trials

Long COVID analysis

COVID-19 impact on trials

Table of Contents

Executive Summary

Introduction

Report Scope

Methodology

COVID-19 Cases & Deaths Continue but at a Lower Rate

COVID-19 Clinical Trials Analysis

COVID-19 Clinical Trials Starts per Month Continue to Decline

Single-Country COVID-19 Trials Dominate

Asia-Pacific Continues to Dominate Single-Country Trials

Europe Still Has the Most Multinational Clinical Trials

North America Has the Most Clinical Trial Sites

Slight Change in Order of US States for COVID-19 Sites

Phase II and Now Completed Trials Dominate the Landscape of COVID-19 Trials

Primary Endpoints Continue to Be Achieved

Low Accrual Rate Was the Primary Cause for Trial Termination

Low Accrual Rate Was the Primary Cause for Trial Termination by Sponsor Type

COVID-19 Clinical Trials for Vaccines & Therapeutics

The Amount of Vaccine COVID-19 Clinical Trials Changes Over Time

Therapeutic COVID-19 Trials Decline More

Phase II Has Most Trials for Vaccine & Therapeutic COVID-19 Clinical Trials

Vaccine & Therapeutic COVID-19 Clinical Trials See the Most Trials in Different Trial Statuses

Sinovac Biotech Still Top Industry Sponsor for Vaccine Trials

Finlay Vaccine Institute Is the Top Non-industry Vaccine Trial Sponsor

Sorrento Therapeutics Is Top Industry Sponsor for COVID-19 Therapeutics Trials

Universities Still Top Non-industry Sponsors

Long COVID Analysis

Attention Has Turned to Long COVID

Majority of Long COVID Trials Are Ongoing

North America Also Has Most Long COVID Sites

US and Florida Top Long COVID Sites by Country and State

A Wide Range of Sponsor Types for Long COVID Trials

Colchicine Is Top Drug Tested for Long COVID

Phase II Trial Completions Expected Most in Upcoming Long COVID Events

Impact of COVID-19 on Clinical Trials

Clinical Trials Disrupted Due to COVID-19

Central Nervous System Leads All Therapy Areas in Disrupted Trials

Where Is the Most Disruption of Clinical Trials?

Emory University Is Top Sponsor with Most Disruption

Resumed Clinical Trials Increasing

Increased Use of Decentralized Clinical Trials

Central Nervous System Utilizes DCTs the Most

The Top Industry Sponsor Using DCTs Is GlaxoSmithKline

University of Oxford and Duke University Top Non-industry Sponsors for DCTs

Telemedicine Is the Most Used DCT Component

More Real-World Evidence Used After the Pandemic

Key Findings

Appendix

Table

Table 1: Total Number of COVID-19 cases and deaths

Figures

Figure 1: Total number of COVID-19 cases and deaths

Figure 2: Number of COVID-19 clinical trials by start date, by month

Figure 3: Number of COVID-19 clinical trials, by multinational versus single-country

Figure 4: Single-country COVID-19 clinical trials, by region and phase

Figure 5: Multinational COVID-19 clinical trials, by region and phase

Figure 6: COVID-19 clinical trial sites, by region

Figures 7 & 8: COVID-19 clinical trial sites, by country and state

Figures 9 & 10: Number of COVID-19 clinical trials, by phase and status

Figure 11: Endpoint status for completed COVID-19 clinical trials

Figure 12: Top reasons for terminated trials, by phase

Figure 13: Top reason for terminated trials, by sponsor type

Figure 14: COVID-19 vaccine clinical trials, by trial start date

Figure 15: COVID-19 therapeutic clinical trials, by trial start date

Figures 16 & 17: Vaccine & therapeutic COVID-19 clinical trials, by phase

Figures 18 & 19: Vaccine & therapeutic COVID-19 clinical trials, by status

Figure 20: Top industry sponsors for COVID-19 vaccine clinical trials

Figure 21: Top non-industry sponsors for COVID-19 vaccine clinical trials

Figure 22: Top industry sponsors for COVID-19 therapeutic clinical trials

Figure 23: Top non-industry sponsors for COVID-19 therapeutic clinical trials

Figure 24: Long COVID clinical trials, by trial start date

Figure 25: Long COVID clinical trials, by trial status

Figure 26: Long COVID clinical trial sites, by region

Figures 27 & 28: Long COVID clinical trial sites, by country and US state

Figure 29: Long COVID clinical trials by sponsor

Figure 30: Long COVID clinical trials by drug

Figure 31: Upcoming long COVID clinical trial events

Figure 32: Clinical trials disrupted due to COVID-19

Figure 33: Disrupted clinical trials, by therapy area

Figures 34 & 35: Disrupted clinical trials activities, by region and country

Figure 36: Disrupted clinical trials, by top sponsors

Figure 37: Resumed clinical trials after being disrupted due to COVID-19, by status

Figure 38: Decentralized clinical trials, by trial start date

Figure 39: Decentralized clinical trials, by therapy area

Figure 40: Top industry sponsors for decentralized clinical trials

Figure 41: Top non-industry sponsors for decentralized clinical trials

Figure 42: Telemedicine clinical trials by trial start year

Figure 43: Number of real-world-evidence trials, by trial end date

Frequently asked questions

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