Myasthenia Gravis Market Opportunity Assessment, Epidemiology, Clinical Trials, Unmet Needs and Forecast to 2032

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Myasthenia Gravis Market Overview

The Myasthenia Gravis (MG) market size for the seven major markets (7MM) was $3 billion in 2022. The market will register a CAGR of more than 8% during 2022-2032. MG is the most common neuromuscular disorder, although it is still classified as a rare disease. It is an autoimmune and neuromuscular disease that is characterized by muscle weakness and fatigue. In most patients, the disease is initially localized and limited to the eye muscles. This weakness can give patients difficulty controlling eye and eyelid movement, facial expressions, chewing, and talking. In some cases, the disease progressively begins to affect respiratory muscles.

Myasthenia Gravis Market Outlook, 2022-2032 ($ Billion)

Myasthenia Gravis Market Outlook, 2022-2032 ($ Billion)

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The Myasthenia Gravis (MG) market research report offers an overview of Myasthenia Gravis, including epidemiology, symptoms, diagnosis, and disease management. The report offers key topics covered including strategic competitor assessment, market characterization, unmet needs, clinical trial mapping, and implications for the Myasthenia Gravis therapeutics market. The report provides information on market drivers, drug classes, and sponsors of Myasthenia Gravis.

Market Size (2022) $3 billion
CAGR (2022-2032) >8%
Forecast Period 2023-2032
Key Countries (7MM) ·        The US

·        The UK

·        Germany

·        France

·        Italy

·        Spain

·        Japan

Key Drug Classes ·        Immunosuppressant

·        Steroid

·        Acetylcholinesterase Inhibitors

·        IgG Receptor Inhibitors

·        Complement Inhibitors

·        Other Classes

Key Sponsors ·        Horizon Therapeutics Plc

·        Regeneron Pharmaceuticals

·        Chugai Pharmaceutical Co Ltd/ Hoffmann-La Roche

·        Immunovant Inc

·        Alexion Pharmaceuticals Inc/AstraZeneca

·        Janssen

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Myasthenia Gravis Market Drivers

  • New DMTs entering the market will drive sales across all 7MM, especially in Europe where only Soliris was approved for use before 2022, with Vyvgart being the first IgG inhibitor coming to the market.
  • Many of the DMTs and pipeline agents received an orphan drug designation, providing them with at least seven years of market exclusivity. This will therefore delay the potential entry of generics into the market for many of the products.

Myasthenia Gravis Market Segmentation by Countries

In 2022, the US represented the largest market for Myasthenia Gravis with over 70% of the 7MM sales in 2022

The key countries in the Myasthenia Gravis market are the US, the UK, Germany, France, Italy, Spain, and Japan. The major driver for the growth of the MG market across the 7MM during the forecast period is the entry of Vyvgart and Ultomiris into the market between the years 2021 and 2022. The entry of Vyvgart Hytrulo, Rystiggo, and Zilucoplan will further drive market growth.

Myasthenia Gravis Market Analysis by Countries, 2022 (%)

Myasthenia Gravis Market Analysis by Countries, 2022 (%)

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Myasthenia Gravis Market Segmentation by Drug Classes

In 2022, complement inhibitors contributed the most sales to the Myasthenia Gravis market.

The key drug classes in the Myasthenia Gravis market are immunosuppressant, steroid, acetylcholinesterase inhibitors, IgG receptor inhibitors, complement inhibitors, and other classes. The current management of MG relies heavily on genericized off-label treatment, especially in patients with ocular MG. The introduction of newly approved DMTs and the entry of new pipeline drugs will heavily increase shares for IgG receptor inhibitors and complement inhibitor groups.

Myasthenia Gravis Market Analysis by Drug Classes, 2022 (%)

Myasthenia Gravis Market Analysis by Drug Classes, 2022 (%)

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Myasthenia Gravis Market Segmentation by Sponsors

Some of the key sponsors associated with the Myasthenia Gravis market are:

  • Horizon Therapeutics Plc
  • Regeneron Pharmaceuticals
  • Chugai Pharmaceutical Co Ltd/ Hoffmann-La Roche
  • Immunovant Inc
  • Alexion Pharmaceuticals Inc/AstraZeneca
  • Janssen

Myasthenia Gravis Market Analysis by Sponsors, 2023

Myasthenia Gravis Market Analysis by Sponsors, 2023

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Segments Covered in this Report

Myasthenia Gravis Country Outlook (Value, $ Billion, 2022-2032)

  • The US
  • The UK
  • Germany
  • France
  • Italy
  • Spain
  • Japan

Myasthenia Gravis Drug Class Outlook (Value, $ Billion, 2022-2032)

  • Immunosuppressant
  • Steroid
  • Acetylcholinesterase Inhibitors
  • IgG Receptor Inhibitors
  • Complement Inhibitors
  • Other Classes

Scope

The report provides:

  • Overview of Myasthenia gravis disease, classification of Myasthenia gravis according to the Myasthenia Gravis Foundation of America guideline, etiology, pathophysiology, and epidemiology of Myasthenia gravis.
  • Current treatment options including product profiles for Myasthenia gravis marketed in the 7MM.
  • Analysis of unmet needs and R&A strategies within the Myasthenia gravis market.
  • Pipeline analysis including product profiles for leading candidates in the 7MM.
  • Myasthenia gravis market outlook including revenue breakdown by market between the years 2022 and 2032.

Key Highlights

Report deliverables include a PowerPoint report and an Excel-based forecast model

Forecast includes the 7 major markets (7MM)

Forecast covers the period 2022-2032

Reasons to Buy

Understand the trends shaping and driving the Myasthenia gravis market

Identify the innovative technologies and key players leading the Myasthenia gravis field

Recognize gaps and areas of unmet need within the Myasthenia gravis market

Determine the current and future outlook for Myasthenia gravis according to key opinion leaders (KOLs)

Track Myasthenia gravis sales from 2022-2032

Alexion
AstraZeneca
Argenx
UCB
Janssen Pharmaceuticals
Horizon Therapeutics Plc
Regeneron Pharmaceuticals
Chugai Pharmaceutical Co Ltd
Hoffmann-La Roche
Immunovant Inc
Alnylam Pharmaceuticals Inc

Table of Contents

1. Preface

1.1. Contents

1.2. Related Reports

1.3. Abbreviations

2. Executive Summary

3. Disease Overview

3.1. Overview of Myasthenia Gravis

3.2. Myasthenia Gravis SWOT Analysis

3.3. Antibody Classification of Myasthenia Gravis

3.4. Classification of Myasthenia Gravis

3.5. MGFA Classification of Myasthenia Gravis

4. Epidemiology

4.1. Diagnosed Prevalent Cases of MG

4.2. Age-Specific Trends in Diagnosed Prevalent Cases of MG

4.3. Sex-Specific Diagnosed Prevalent Cases of MG

4.4. Sources and Methodology for MG Prevalence

4.5. Sources and Methodology for MG

5. Current Treatment Options

5.1. Treatment Paradigm

5.2. Current Treatment Options

5.3. Current Treatment Options – KOL Perspective

5.4. Product Profile: Immunosuppressants (Tacrolimus, Cyclosporine, Azathioprine)

5.5. Product Profile: Corticosteroids (Prednisone, Hydrocortisone, Methylprednisone)

5.6. Product Profile: Acetylcholinesterase Inhibitors (Pyridostigmine, Neostigmine, Ambenonium)

5.7. Product Profile: IgG Inhibitors (Vyvgart, Vyvgart Hytrulo, Rystiggo)

5.8. Product Profile: Complement Inhibitors (Soliris, Ultomiris, Zilbrysq)

5.9. Product Profile: Other Classes (Rituxan)

6. Unmet Needs and Opportunities

6.1. Unmet Needs in Myasthenia Gravis

6.2. Cost of Disease Modifying Therapies

6.3. Prognostic Biomarkers

6.4. Public and Physician Awareness

6.5. Frequency of Administration

6.6. Standardization of Classification and Treatment Guidelines

7. R&D Strategies

7.1. Trends in Clinical Trial Design in Myasthenia Gravis

7.2. R&D strategies in Myasthenia Gravis

7.3. Trends in Deal-Making in Myasthenia Gravis

8. Pipeline Assessment

8.1. Myasthenia Gravis Pipeline Overview

8.2. Late-Stage Pipeline Agents for Myasthenia Gravis

8.3. Product Profile: Horizon Therapeutic’s Uplizna (inebilizumab)

8.4. Product Profile: Regeneron’s Pozelimab in Combination with Alnylam’s Cemdisiran

8.5. Product Profile: Roche’s Enspryng (satralizumab)

8.6. Product Profile: Immunovant’s batoclimab

8.7. Product Profile: Alexion’s/AstraZeneca’s gefurulimab

8.8. Product Profile: Janssen’s nipocalimab

9. Market Outlook

9.1. Myasthenia Gravis Market Forecast

9.2. Market Drivers and Barriers

10. Appendix

10.1. Primary Research – KOL Information

10.2. About the Authors

11. Contact Us

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