OpportunityAnalyzer: Ovarian Cancer – Opportunity Analysis and Forecasts to 2025
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Ovarian cancer is the fifth most common malignancy in women and is the leading cause of death amongst gynecological cancers. Due to the nonspecific nature of disease symptoms, the majority of ovarian cancer patients are diagnosed with advanced-stage disease, at which point the prognosis is poor. Current standard of care therapies focus on debulking surgery and platinum-based chemotherapy, with carboplatin and paclitaxel being the gold standard. The majority of patients respond well to initial first-line therapy and enter into remission, however over 80% of patients will relapse and require multiple lines of therapy.
For many years the ovarian cancer drug market has been fairly stagnant, mainly due to the high use of generics and the lack of successful development of new innovative therapies. However, with the recent approvals of Avastin and the PARP inhibitors Lynparza (olaparib), Rubraca (rucaparib), and Zejula (niraparib), the market is beginning to diversify. New understanding of the heterogeneity and biology of ovarian cancer has led to the active development of new targeted therapies, immuno-oncology (IO) drugs, and next-generation chemotherapies. A greater understanding of the tumor microenvironment is expected to occur over the forecast period, which is anticipated to further drive the successful development of new patient-specific therapies. GlobalData is predicting a total of 9 new entrants to launch over the forecast period from 2015-2025. Competition will be particularly fierce amongst PARP inhibitors as they continue to establish their place in the treatment paradigm of ovarian cancer.
Key Questions Answered
How will the ovarian cancer market landscape in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan) change from 2015–2025?
What are the most promising late-stage pipeline drugs in ovarian cancer?
How do the clinical and commercial attributes of late-stage pipeline therapies compare with one another, and against existing treatment options?
What are the unmet needs in ovarian cancer treatment management?
What drivers and barriers will affect ovarian cancer therapeutics sales in the 7MM over the forecast period?
Overview of ovarian cancer, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and current management strategies.
Topline ovarian cancer market revenue from 2015–2025. Annual cost of therapy (ACOT) and major pipeline product sales in this forecast period are included.
Key topics covered include current treatment options, unmet needs and opportunities, and the drivers and barriers affecting ovarian cancer therapeutics sales in the 7MM.
Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, synopses of innovative early-stage projects, and detailed analysis of late-stage pipeline products.
Analysis of the current and future market competition in the 7MM ovarian cancer therapeutics market. Insightful review of the key industry drivers, restraints, and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Reasons to Buy
The report will enable you to:
Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.
Develop business strategies by understanding the trends shaping and driving the 7MM ovarian cancer therapeutics market.
Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the ovarian cancer therapeutics market in the future.
Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships.
Merck & Co.
Table of Contents
Table of Contents
1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Ovarian Cancer: Executive Summary
2.1 Dramatic Growth, Driven by the Establishment of Standard of Care Maintenance Therapies, Is Projected for the 7MM Ovarian Cancer Market from 2015 to 2025
2.2 AstraZeneca, Tesaro, and Clovis are Poised for a Showdown in the PARP Inhibitor Ovarian Cancer Treatment Market for BRCA+, BRCA-like, and All Comers
2.3 Roche Expected to Remain Market Leader on the Heels of Avastin-based Combinations and the 7MM’s Second Programmed Death-Ligand 1 Inhibitor, Tecentriq, to Compete with Merck KGaA/Pfizer’s First-to-Market Bavencio
2.4 Unmet Need of More Therapies for Recurrent Patients in Later Lines of Therapy, Especially Platinum-Resistant Patients, Anticipated to be Partially Fulfilled, with Opportunities Remaining
2.5 What Do Physicians Think?
3.2 Related Reports
3.3 Upcoming Related Reports
4 Disease Overview
4.1 Etiology and Pathophysiology
4.2 Staging Systems
4.3 Risk Factors, Symptoms, and Screening
4.4 Prognosis and Quality of Life
5.1 Disease Background
5.2 Risk Factors and Comorbidities
5.3 Global Trends
5.3.1 7MM Incidence Trends
5.3.2 7MM Trends in Relative Survival
5.4 Forecast Methodology
5.4.1 Sources Used Tables
5.4.2 Forecast Assumptions and Methods
5.4.3 Sources Not Used
5.5 Epidemiological Forecast for Ovarian Cancer (2015–2025)
5.5.1 Diagnosed Incident Cases of Ovarian Cancer
5.5.2 Age-Specific Diagnosed Incident Cases of Ovarian Cancer
5.5.3 Age-Standardized Diagnosed Incidence of Ovarian Cancer
5.5.4 Diagnosed Incident Cases of Primary Peritoneal Cancer
5.5.5 Five-Year Diagnosed Prevalent Cases of Ovarian Cancer and Primary Peritoneal Cancer
5.6.1 Epidemiological Forecast Insight
5.6.2 Limitations of the Analysis
5.6.3 Strengths of the Analysis
6 Current Treatment Options
6.2 Diagnosis and Treatment
6.2.2 Treatment Guidelines
6.3 Clinical Practice and Leading Prescribed Drugs
6.4 Product Profiles – Major Brands, Angiogenesis Inhibitors
6.4.1 Avastin (bevacizumab)
6.5 Product Profiles – Major Brands, PARP Inhibitors
6.5.1 Lynparza (olaparib)
6.5.2 Rubraca (rucaparib)
6.5.3 Zejula (niraparib)
6.6 Product Profiles – Major Brands, Next-Generation Chemotherapies
6.6.1 Yondelis (trabectedin)
6.7 Generic Chemotherapy
6.7.1 Front-Line Treatment (Adjuvant/First Line)
6.7.2 Recurrent Disease
7 Unmet Needs Assessment and Opportunity Analysis
7.2 Improved First-line Therapies
7.2.1 Unmet Need
7.2.2 Gap Analysis
7.3 Alternative Treatment Options for Platinum-Refractory/Resistant Patients
7.3.1 Unmet Need
7.3.2 Gap Analysis
7.4 Individualized Treatment Approaches
7.4.1 Unmet Need
7.4.2 Gap Analysis
7.5 Therapy Option for Histological Subtypes Beyond High-Grade Serous Ovarian Cancer
7.5.1 Unmet Need
7.5.2 Gap Analysis
7.6 An Early Stage Diagnostic for Ovarian Cancer
7.6.1 Unmet Need
7.6.2 Gap Analysis
8 Research and Development Strategies
8.1.1 Optimizing Chemotherapy
8.1.2 Targeted Therapies – A Patient Specific Approach
8.1.3 Immunotherapies – A Patient Specific Approach
8.1.4 Combination Therapies
8.1.5 Licenses and Alliances
8.2 Clinical Trial Design
8.2.1 Current Clinical Trial Endpoints
8.2.2 The Future of Clinical Trial Endpoints
8.2.3 Moving Beyond the Current Platinum Sensitive/Resistant Paradigm for Patient Recruitment in Recurrent Clinical Trials
9 Pipeline Assessment
9.2 Product Profiles – Immune Checkpoint Modulators
9.2.1 Bavencio (avelumab)
9.2.2 Opdivo (nivolumab)
9.2.3 Tecentriq (atezolizumab)
9.3 Product Profiles – Cancer Vaccines
9.3.1 Vigil (gemogenovatucel-T)
9.4 Product Profiles – Vascular Disrupting Agents
9.4.1 Fosbretabulin tromethamine
9.5 Product Profiles – PARP Inhibitors
9.6 Product Profiles – Targeted Cytotoxic Therapies (Antibody-Drug Conjugates)
9.6.1 Mirvetuximab soravtansine
9.7 Product Profiles – Next-Generation Chemotherapies
9.7.1 Opaxio (paclitaxel poliglumex)
9.7.3 Apealea/Paclical (paclitaxel)
9.8 Innovative Early Stage Approaches
9.8.1 Immune Checkpoint Modulators
9.8.2 Oncolytic Viruses
9.8.3 Angiogenesis Inhibitors
9.8.4 Interleukin-12 Agonists
9.8.5 Toll-Like Receptor 8 Agonists
9.8.6 Cancer Vaccines
9.8.7 Kinase Inhibitors
9.8.8 Targeted Cytotoxic Therapies
9.8.9 P53 Agonists
9.9 Other Notable Drugs in Clinical Development
10 Pipeline Valuation Analysis
10.1 Clinical Benchmark of Key Pipeline Products
10.2 Commercial Benchmark of Key Pipeline Therapies
10.3 Competitive Assessment
10.4 Top-Line Ten-Year Forecast
11.4 Forecasting Methodology
11.4.1 Percentage of Drug-Treated Patients
11.4.2 Drugs Included in Each Therapeutic Class
11.4.3 Launch and Patent Expiry Dates
11.4.4 General Pricing Assumptions
11.4.5 Average Body Weight and Surface Area Across the 7MM
11.4.6 General Forecast Assumptions
11.4.7 Individual Drug Assumptions
11.4.8 Generic and Biosimilar Erosion
11.4.9 Pricing of Pipeline Agents
11.5 Primary Research
11.5.1 Physicians and Specialists Included in This Study
11.5.2 Online Survey of High-Prescribing Physicians
11.6 About the Authors
11.6.3 Therapy Area Director
11.6.4 Global Director of Therapy Analysis and Epidemiology
11.6.5 Global Head of Healthcare
11.7 About GlobalData
11.8 Contact Us
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