Trypanosomiasis – Drugs In Development, 2024

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Trypanosomiasis, also known as sleeping sickness in humans and nagana in animals, is a parasitic disease caused by protozoan parasites of the genus Trypanosoma. There are two main forms of the disease, each caused by different species of Trypanosoma.

African trypanosomiasis (sleeping sickness) is transmitted by tsetse flies and is predominantly found in sub-Saharan Africa. It is caused by two subspecies of the parasite: Trypanosoma brucei gambiense causes the chronic form of sleeping sickness, responsible for over 90% of reported cases, which progresses slowly and can last for years without symptoms; Trypanosoma brucei rhodesiense causes the acute form, where symptoms appear within weeks to months and can lead to severe complications if untreated.

American Trypanosomiasis (Chagas disease), endemic in Central and South America, is caused by the parasite Trypanosoma cruzi. Chagas disease is primarily transmitted by triatomine insects (also known as “kissing bugs”) that feed on blood. The parasites can also be transmitted through blood transfusions, organ transplants, or from mother to child during pregnancy.

The Trypanosomiasis drugs in development market research report provide comprehensive information on the therapeutics under development for Trypanosomiasis, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also covers the descriptive pharmacological action and product description of the therapeutics, and the latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Trypanosomiasis and features dormant and discontinued products.

Note:

* This is an “on-demand” report and will be delivered within 2 business days (excluding weekends and holidays) of the purchase.

* Certain sections in the report may be removed or altered based on the availability and relevance of data.

Quick View – Trypanosomiasis
Key Targets
· Cruzipain; Lanosterol 14 Alpha Demethylase; Proteasome ; Glycylpeptide N Tetradecanoyltransferase; Ergosterol ; DNA; Dual Specificity Protein Kinase CLK1; DNA Topoisomerase II; Cell Membrane; and Casein Kinase 1 Isoform 2
Key Mechanisms of Action
· Cruzipain Inhibitor; Lanosterol 14 Alpha Demethylase Inhibitor; Proteasome Inhibitor; Glycylpeptide N Tetradecanoyltransferase Inhibitor; Ergosterol Inhibitor; DNA Inhibitor; DNA Topoisomerase II Inhibitor; Dual Specificity Protein Kinase CLK1 Inhibitor; Cell Membrane Disruptor; and Adenosylmethionine Decarboxylase Inhibitor
Key Routes of Administration
· Oral; Topical; Sublingual; Nasal; Subcutaneous; Intramuscular; and Intravenous
Key Molecule Types
· Small Molecule; Subunit Vaccine; Live Attenuated Vaccine; Vaccine; Recombinant Vector Vaccine; DNA Vaccine; Conjugate Vaccine; Antisense Oligonucleotide; Recombinant Protein; and Inactivated Vaccine
Major Companies
· Drugs for Neglected Diseases initiative; Novartis AG; University of Dundee; GSK plc; Central Drug Research Institute; Collaborations Pharmaceuticals Inc; Eisai Co Ltd; Foundation For Neglected Disease Research; McGill University Health Center; and University of California San Francisco

Scope

  • Therapeutics in Development: Covering 108 molecules, with 47 developed by companies and the rest by universities/institutes.
  • Analysis Parameters: Offering insights by stage of development, drug target, MoA, RoA, and molecule type for a comprehensive overview.
  • Pharmacological Insights: Understand the descriptive pharmacological action of therapeutics.
  • Development History: Access the complete research and development history.
  • Latest News and Press Releases: Stay updated with the latest developments through comprehensive news coverage.

Reasons to Buy

  • Holistic insights: Understand the broad spectrum of Trypanosomiasis therapeutics, aiding strategic decision-making with insights into stages, targets, MoA, RoA and molecule types.
  • Pipeline Exploration: Explore the detailed Trypanosomiasis pipeline, offering nuanced analysis of drug targets, mechanisms of action and routes of administration for varied decision-making.
  • Comprehensive R&D: Access thorough R&D histories, providing a comprehensive understanding of Trypanosomiasis treatments for adaptable decision-making.
  • Save valuable hours: Identify key players steering innovation in therapeutics, enabling strategic partnerships.

Key Players

7 Hills Pharma LLC
AN2 Therapeutics Inc
Appili Therapeutics Inc
AstraZeneca Plc
Bacoba AG
Biokawthar Technologies SAS
BioLingus AG
Central Drug Research Institute
Cesa Alliance SA
Collaborations Pharmaceuticals Inc
ConserV Bioscience Ltd
Daiichi Sankyo Co Ltd
DetectoGen Inc
Diakonos Research Ltd
Drugs for Neglected Diseases initiative
Dultech Advanced Sciences
Eisai Co Ltd
F. Hoffmann-La Roche Ltd
Flanders Institute for Biotechnology
Foundation For Neglected Disease Research
Fox Chase Chemical Diversity Center Inc
Ghent University
GSK plc
Helmholtz Center Munich German Research Center for Health and Environment GmbH
Helmholtz Centre for Infection Research
Hospital Universitrio Professor Edgard Santos
iBio Inc
Immune Modulation Inc
Impetis Biosciences Ltd
Institut Pasteur Korea
Isfahan University of Medical Sciences
Kitasato University
Macrophage Therapeutics Inc
ManRos Therapeutics
Massachusetts College of Pharmacy and Health Sciences
McGill University Health Center
MedC Biopharma Ltd
MediSynergics LLC
Molecular Targeting Technologies Inc
Mycosynthetix Inc
Nanomerics Ltd
NorthShore University Health System
Novartis AG
NYU Langone Health System
Oblita Therapeutics BVBA
Ohio State University
Pai Life Sciences Inc
Pasteur Institute
Paxmedica Inc
Pfizer Inc
Pharos iBio Co Ltd
Rakta Therapeutics Inc
RIKEN
Sanofi
Satellos Bioscience Inc
SATT AxLR SAS
Scynexis Inc
Selva Therapeutics Inc
Spanish National Research Council
St. John's University
Synstar Japan Co Ltd
The Lundquist Institute
Trinity College Dublin
University of Bologna
University of California San Francisco
University of Dundee
University of Edinburgh
University of Georgia
University of Glasgow
University of Nantes
University of Strathclyde
University of Texas at El Paso
University of Valencia
University of Washington
University of York
Vanderbilt University
Walter Reed Army Institute of Research

Table of Contents

Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Overview

Therapeutics Development

Pipeline Overview

Pipeline by Companies

Pipeline by Universities/Institutes

Drugs Under Development by Companies

Drugs under Development by Universities/Institutes

Therapeutics Assessment

Assessment by Target

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Companies Involved in Therapeutic Development

Drug Profiles

Dormant Projects

Discontinued Drugs

Product Development Milestones

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

Table

List of Tables

Number of Drugs under Development, 2024

Number of Drugs under Development by Companies, 2024

Number of Drugs under Development by Universities/Institutes, 2024

Drugs under Development by Companies, 2024

Drugs under Development by Universities/Institutes, 2024

Number of Drugs by Stage and Target, 2024

Number of Drugs by Stage and Mechanism of Action, 2024

Number of Drugs by Stage and Route of Administration, 2024

Number of Drugs by Stage and Molecule Type, 2024

Dormant Projects, 2024

Discontinued Drugs, 2024

Figures

List of Figures

Number of Drugs under Development, 2024

Number of Drugs under Development by Companies, 2024

Number of Drugs under Development by Universities/Institutes, 2024

Number of Drugs by Top 10 Targets, 2024

Number of Drugs by Stage and Top 10 Targets, 2024

Number of Drugs by Top 10 Mechanism of Actions, 2024

Number of Drugs by Stage and Top 10 Mechanism of Actions, 2024

Number of Drugs by Top 10 Routes of Administration, 2024

Number of Drugs by Stage and Top 10 Routes of Administration, 2024

Number of Drugs by Top 10 Molecule Types, 2024

Number of Drugs by Stage and Top 10 Molecule Types, 2024

Frequently asked questions

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