GlobalData Plc
  • Press Release

    Limited access to novel therapies could hinder effective personalized cancer treatment in the UK, says GlobalData

Tagged: / / / / / /

NICE recently rejected NHS funding of Kymriah for DLBCL despite recognizing that the drug has significant clinical benefits. As a result, patients with DLBCL in the UK could now potentially lose out on receiving life-saving treatment, according to GlobalData, a leading data and analytics company.

Following the EMA approval of Novartis’ Kymriah (tisagenlecleucel) for refractory/relapsed (R/R) diffuse large B-cell lymphoma (DLBCL) in adults last month, on September 19, 2018, NICE rejected NHS funding of Kymriah for DLBCL.

The NHS was preparing to embrace the breakthrough CAR-T cancer treatment and the company offered a confidential discount on the list price of £282,000. Nevertheless the discounted price was still above the range that NICE considers an acceptable use (no more than £50,000 per year) of NHS funds on an end-of-life drug.

NICE based its decision on the lack of data comparing Kymriah to the gold-standard chemotherapy, and concluded that Kymriah is not cost-effective for routine NHS funding or use within the Cancer Drugs Fund (CDF).

In contrast, on September 5, 2018, NICE gave the green light to Kymriah for patients with R/R B-cell acute lymphoblastic leukemia (ALL) up to 25 years old, a much smaller market, within a record-breaking 10 days just after it obtained marketing authorization from the EMA.

Dr Edit Kovalcsik, Managing Analyst at GlobalData, comments: “NICE’s rejection of Kymriah for DLBCL does not come as a complete surprise after a series of dismissals of other immune-oncology drugs for regular NHS funding, including Gilead/Kite’s Yescarta (axicabtagene ciloleucel) in R/R DLBCL and R/R primary mediastinal large B-cell lymphoma (PMBCL).

“Amid the uncertainty of access to new cancer drugs, on the other hand, the UK is keen to become a global hub in biotherapeutics.”

According to GlobalData’s report: ‘PharmaFocus: Visual Analysis of Immuno-Oncology Development and Opportunities’ the US has historically led the development of CAR cell therapies, but China has recently become the most significant contributor to their development, with 126 clinical trials started prior to Q2 2017 in comparison with 121 in the US. The UK is the third country in terms of development, far behind, with nine clinical trials exploring CAR cell therapies.

IMAGE FOR PUBLICATION: Please click here for chart: Development of CAR Cell Therapies by Country, 2009-2017

In order to speed up progress in immunotherapy to fight against cancer, UCL, King’s College London, Queen Mary, University of London, and the Francis Crick Insitute teamed up  on September 17, 2018 to establish a virtual ‘London centre’, a collaboration made possible by a £14 million catalyst from Cancer Research UK. As a result, more Londoners will be able to access cancer trials and treatments that can extend life or even have the potential to cure cancer.

Kovalcsik concludes: “Beyond access to clinical trials, the uncertainty of NHS patients to receive the best cancer treatment needs to be addressed. Exploitation of digital technology and artificial intelligence in the analysis of the NHS electronic health records could increase effectiveness of drug development and as a result reduce the cost of breakthrough medicine.”

ENDS

For more information

To gain access to our latest press releases: GlobalData Media Centre

Analysts available for comment. Please contact the GlobalData Press Office:

Email: pr@globaldata.com

EMEA & Americas: +44 (0)207 832 4399

Asia-Pacific: +91 40 6616 6809

To gain access to our latest press releases and expert analysis on developments in your industry, please connect with us on:

GlobalData.com | LinkedIn | Twitter

About GlobalData

4,000 of the world’s largest companies, including over 70% of FTSE 100 and 60% of Fortune 100 companies, make more timely and better business decisions thanks to GlobalData’s unique data, expert analysis and innovative solutions, all in one platform. GlobalData’s mission is to help our clients decode the future to be more successful and innovative across a range of industries, including the healthcare, consumer, retail, financial, technology and professional services

Related Intelligence

Want more Insight like this?

Our interactive subscription platform has the most comprehensive data and analysis in your industry.

Request a Demo

Related Consulting

How can we help your business?

Our consultants are skilled in every specialist market niche to deliver solutions specifically designed for your individual requirements.

Request a Callback

Media Enquiries

If you are a member of the press or media and require any further information, please get in touch, as we’re very happy to help.

Emailpr@globaldata.com
PhoneEMEA: +44 207 832 4399
PhoneAPAC: +91 40 6616 6809
Onlinecontact online

56% of #consumers are concerned about the impact of diet. Join us for more insight @incosmetics #cosmetics #trends… https://t.co/wJOJOqYIJF