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Recently, Brazil has steadily climbed the chart of the top 10 countries with the highest total of COVID19 cases, now ranking number two just behind the US. The epidemiology forecast shows that Brazil has not reached peak and it is likely that the outbreak will continue to worsen there, says GlobalData, a leading data and […]
Remdesivir faces challenges from vaccines, says GlobalData
While Gilead Sciences’ remdesivir has been declared the new standard of care for COVID-19 despite some mixed trial results, it will continue to face challenges from vaccines in the pipeline, says GlobalData, a leading data and analytics company. Once a vaccine is developed, the demand for remdesivir to treat COVID-19 patients will decline. Johanna Swanson, […]
Five CMOs raise eligibility questions after taking out PPP loans despite remaining open
The news that at least five publicly traded contract manufacturing organizations (CMOs) took out Paycheck Protection Program (PPP) loans from the US Government’s $659bn loan program, despite remaining open for business and despite official guidance that the money was not intended for large public companies, raises questions about the eligibility of the participating companies for […]
Over 72% of COVID-19 treatments are at pre-clinical or discovery stages
A large number of COVID-19 treatment options (620 novel and repurposed drugs as of mid-May) have joined the drug development pipeline, with over 72% of these drugs in preclinical or discovery stages of development. These drugs are in the initial stages of feasibility and drug safety investigation to show that they have an effect on […]
Outsourced blockbuster drugs manufactured in Spanish facilities could significantly disrupt supply
As of mid-May, there were 131 contract manufacturing organizations (CMOs) in Spain with 161 Spanish sites, according to the GlobalData’s Contract Service Provider database, which details the manufacturing relationships for novel products approved in the US and EU. The company found that the top ten outsourced drugs, by 2019 revenue, that are contract manufactured in […]
Hydroxychloroquine’s effectiveness for COVID19 treatment continues to be debated, says GlobalData
There is no clinical evidence that hydroxychloroquine is effective against COVID19. Some studies using hydroxychloroquine have shown no benefits or even an increase in risk of death, but the number of clinical trials investigating hydroxychloroquine as a primary or secondary intervention continues to expand to determine whether the drug candidate is a key contender as […]
Liquidia’s pocket-sized PAH treatment LIQ-861 likely to be favored by patients
If the development of Liquidia Technologies’ LIQ-861 dry powder inhaled formulation of treprostinil, indicated for the treatment of pulmonary arterial hypertension (PAH) is successful, the drug will likely be favored by patients and physicians as it will likely increase patient compliance, says GlobalData, a leading data and analytics company. Kajal Jaddoo, MSc, Associate Healthcare Analyst […]
Oyster Point Pharma’s OC-01 Phase III results could trigger wave of hope for patients with dry eye syndrome
Oyster Point announced that top-line results from its Phase III Onset-2 trial evaluating OC-01 for dry eye disease (DES) in early May. The results demonstrated a statistically significant improvement in patients gaining ≥10mm in Schirmer’s score at Week 4 versus control. The positive results from this late-stage clinical trial could trigger a wave of hope […]
COVID-19 is driving innovations in healthcare staff training process
COVID-19–accelerated adoption of emerging technologies will revolutionize the frontline staff education and training process and become a new normal once the COVID-19 crisis ends, says GlobalData, a leading data and analytics company. Urte Jakimaviciute, MSc, Senior Director of Market Research, commented: “The shortage of trained medical staff has obliged governments to consider alternative ways of […]
Gilead’s remdesivir gets MHRA green light, but only targets select group of COVID-19 patients
GlobalData anticipates that Gilead’s remdesivir will target a select severity group of COVID-19 patients, and it remains questionable as to how treatment with the drug will be initiated and optimized. Angad Lotay MPharm, Infectious Diseases Analyst at GlobalData, states: “Gilead’s remdesivir was trialled in a number of patients with varying severities, however, it was noted […]
Clinical trials are adapting to a patient safety concerns over COVID-19
When clinical trials that were delayed since the beginning of the COVID-19 pandemic resume, it is highly probable that potential trial subjects will have a heightened sense of anxiety regarding COVID-19 and therefore may have reservations about participating, says GlobalData, a leading data and analytics company. Mohamed Abukar, MSc, Clinical Trials Analyst at GlobalData, comments: “In […]
India risking surge of COVID19 cases as strict lockdown measures are loosened, says GlobalData
Based on the current trajectory of COVID19 daily confirmed cases, India will be the fourth most heavily affected country in the world behind the US, Brazil and Russia in the next two weeks. It will take at least six additional weeks of continued strict social distancing efforts to reduce the new positive cases to fewer […]
Operation Warp Speed’s finalists for COVID-19 vaccine are announced, but vaccines need to be accessible globally to control the pandemic
Following the news that the US Government’s ‘Operation Warp Speed’ picked AstraZeneca, Johnson & Johnson, Merck, Moderna, and Pfizer as finalists for COVID-19 vaccine funding; Philipp Rosenbaum, PhD, Infectious Diseases Analyst at GlobalData, a leading data and analytics company, offers his view: “Operation Warp Speed’s goal to support the production of 300 million vaccine doses […]
MERS vaccine shows promise for COVID-19 vaccine development
A recent Phase I clinical trial performed at the University Medical Center Hamburg-Eppendorf for a Middle East respiratory syndrome (MERS) vaccine has produced positive results that give hope that a vaccine candidate for COVID-19 can be developed using the same technique. This provides evidence that a coronavirus vaccine can be made that is both safe and triggers […]
Interferon-lambda has potential to reduce transmission of COVID-19
The spread of the COVID-19 can be slowed by the use of interferon-lambda, which has the ability to inhibit replication of COVID-19 in the lungs and gastrointestinal tracts. This reduced replication of the virus lessens the amount of viral shedding and can reduce the chances of viral transmission, says GlobalData a leading data analytics company. […]
Clinical trials disrupted by COVID-19 are slowly resuming
The COVID-19 pandemic has been disrupting clinical trials globally, but as countries reopen, these trials are now resuming. As of 28th May, over 130 COVID-19 disrupted clinical trials were resuming, with the US leading the way in the number of trials resumed by site locations at 69% of the resumed trials, says GlobalData, a leading data […]
Local production of APIs in India for COVID-19 repurposed drugs likely to offer competitive advantage, says GlobalData
The local production of the active pharmaceutical ingredients (API) for some of the key COVID-19 repurposed drugs including remdesivir, favipiravir and hydroxychloroquine (HCQ) is likely to offer a competitive advantage for the formulations manufactured in India in terms of supply and price, says GlobalData, a leading data and analytics company. According to GlobalData’s COVID-19 Executive […]
Some injectable sedatives used for ventilated COVID-19 patients are experiencing shortages, finds GlobalData
The ongoing COVID-19 pandemic has increased the demand for drugs used to sedate the mechanically ventilated COVID-19 patients and has resulted in shortages for some of these drugs, specifically propofol and dexmedetomidine hydrochloride, says GlobalData, a leading data and analytics company. As the COVID-19 pandemic continues to spread, about 20% of hospitalized COVID-19 patients need […]
COVID-19 to temporarily setback blockchain implementation in global pharmaceutical supply chains
Even though blockchain stands out as a potential solution to improve pharmaceutical supply chains, COVID-19 may become a hindrance rather than a trigger in the technology’s future implementation and uptake, says GlobalData, a leading data and analytics company. Urte Jakimaviciute, MSc, Senior Director of Market Research at GlobalData, comments: “A blockchain-based distributed ledger can provide […]
Anti-TNF therapies could treat patients with COVID-19-related acute respiratory distress, says GlobalData
Remicade (infliximab) and Humira (adalimumab) are the established anti-tumor necrosis factor (TNF) therapies that have been shown to decrease inflammation in diseases such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). As these anti-TNF therapies reduce inflammation, they could treat COVID-19 patients with acute respiratory distress (ARDS), says GlobalData, a leading data and analytics […]