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Product Insights
Integrin Beta 7 (Gut Homing Receptor Beta Subunit or ITGB7) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Integrin Beta 7 Pipeline Drugs Market Report Overview Integrin beta-7 is an integrin protein encoded by the ITGB7 gene. It interacts with the cell surface adhesion molecules MADCAM1, which is normally expressed by the vascular endothelium of the gastrointestinal tract. The Integrin Beta 7 pipeline drugs market research report provides comprehensive information on the Integrin Beta 7 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report...
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Metabotropic Glutamate Receptor 4 (GPRC1D or MGLUR4 or GRM4) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Metabotropic Glutamate Receptor 4 Pipeline Drugs Market Report Overview Metabotropic Glutamate Receptor 4 is a protein encoded by the GRM4 gene. It is a G-protein coupled receptor for glutamate. Glutamate binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. The Metabotropic Glutamate Receptor 4 (MGLUR4) drugs market research report provides comprehensive information on the MGLUR4 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action...
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Survival Motor Neuron Protein (Component Of Gems 1 or Gemin 1 or SMN1 or SMN2) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
SMN Protein Pipeline Products Market Report Overview Survival of motor neurons or survival motor neurons (SMN) is a protein encoded by the SMN1 and SMN2 genes. The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs). They play an important role in the splicing of cellular pre-mRNAs. They ensure the correct splicing of U12 intron-containing genes that is important for normal motor and proprioceptive neuron development. They are required for resolving RNA-DNA hybrids created by...
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Toll Like Receptor 4 (hToll or CD284 or TLR4) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Toll Like Receptor 4 Pipeline Drugs Market Report Overview Toll-like receptor 4 is a protein encoded by the TLR4 gene. This receptor is mostly expressed in the placenta and the myelomonocytic subpopulation of leukocytes. It is involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. The Toll Like Receptor 4 (TLR4) pipeline drugs market research report provides comprehensive information on the TLR4 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of...
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Interleukin 7 Receptor Subunit Alpha (CDw127 or CD127 or IL7R) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Interleukin 7 Receptor Subunit Alpha Pipeline Drugs Market Report Overview Interleukin-7 receptor is a protein found on the surface of cells. It acts as a receptor for thymic stromal lymphopoietin (TSLP) and plays an important role in T-cell acute lymphoblastic leukemia, multiple sclerosis, rheumatoid arthritis, and juvenile idiopathic arthritis. The Interleukin 7 Receptor Subunit Alpha pipeline drugs market research report provides comprehensive information on the Interleukin 7 Receptor Subunit Alpha targeted therapeutics, complete with analysis by indications, stage of development,...
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Serine/Threonine Protein Kinase A Raf (Proto Oncogene A Raf or Proto Oncogene Pks or ARAF or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Serine/Threonine Protein Kinase A Raf Pipeline Products Market Report Overview Serine/threonine-protein kinase A-Raf is an enzyme that in humans is encoded by the ARAF gene. It is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It regulates the TOR signaling cascade. The Serine/Threonine Protein Kinase A Raf pipeline market research report provides comprehensive information on the therapeutics under development for Serine/Threonine Protein Kinase A Raf, complete with analysis by stage of development, drug target,...
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Alpha 2C Adrenergic Receptor (Alpha 2 Adrenergic Receptor Subtype C4 or Alpha 2C Adrenoreceptor or ADRA2C) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Alpha 2C Adrenergic Receptor Pipeline Drugs Market Report Overview Alpha-2C Adrenergic Receptor or ADRA2C is an alpha-2 adrenergic receptor that mediates the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. This receptor plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The Alpha 2C Adrenergic Receptor (ADRA2C) pipeline drugs market research report provides comprehensive information on the ADRA2C targeted therapeutics, complete with analysis by indications, stage...
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Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Leptin Receptor Pipeline Drugs Market Report Overview Leptin Receptor or LEP-R is a protein encoded by the LEPR gene. It acts as a receptor for the hormone LEP/leptin. Upon binding it mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade. The Leptin Receptor pipeline drugs market research report provides comprehensive information on the Leptin Receptor targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route...
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Alpha N-Acetylglucosaminidase (N Acetyl Alpha Glucosaminidase or NAGLU or EC 3.2.1.50) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Alpha N-acetylglucosaminidase Pipeline Products Market Report Overview Alpha N-acetylglucosaminidase is a protein associated with Sanfilippo syndrome. This enzyme is located in lysosome compartments within cells that digest and recycle different types of molecules. Alpha N-acetylglucosaminidase is involved in the stepwise breakdown of large molecules called glycosaminoglycans (GAGs). Alpha N-acetylglucosaminidase removes a sugar called N-acetylglucosamine when it is at the end of the GAG chain. The Alpha N-Acetylglucosaminidase pipeline market research report provides comprehensive information on the therapeutics under development for...
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Ephrin Type B Receptor 4 (Hepatoma Transmembrane Kinase or Tyrosine Protein Kinase TYRO11 or EPHB4 or EC 2.7.10.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Ephrin Type B Receptor 4 Pipeline Drugs Market Report Overview Ephrin type-B receptor 4 is a protein encoded by the EPHB4 gene. It binds promiscuously to transmembrane ephrin-B family ligands residing on adjacent cells which leads to contact dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. It plays a central role in heart morphogenesis...
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Interleukin 1 Receptor Associated Kinase 4 (Renal Carcinoma Antigen NY REN 64 or IRAK4 or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
IRAK-4 Pipeline Products Market Report Overview Interleukin-1 receptor-associated kinase 4 (IRAK-4) is a protein kinase involved in signaling innate immune responses from Toll-like receptors. Mutations in IRAK-4 result in IRAK4 deficiency and recurrent invasive pneumococcal disease. It phosphorylates E3 ubiquitin ligases Pellino proteins to promote pellino-mediated polyubiquitination of IRAK1. The ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. MAP3K7/TAK1 activates IKKs leading to NF-kappa-B nuclear translocation and activation. The IRAK-4 pipeline...
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Cell Division Cycle 7 Related Protein Kinase (CDC7 or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Cell division cycle 7-related protein kinase is an enzyme encoded by the CDC7 gene. Its phosphorylate substrates regulate the G1/S phase transition and DNA replication. Overexpression of CDC7 is associated with neoplastic transformation for some tumors. The Cell Division Cycle 7-related Protein Kinase pipeline drugs market research report provides comprehensive information on the therapeutics under development for Cell Division Cycle 7-related Protein Kinase, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA),...
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Bcl 2 Like Protein 1 (Apoptosis Regulator BclX or BCLX or BCL2L1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Bcl-2-like protein 1 is a potent inhibitor of cell death. The Bcl 2 Like Protein 1 (Apoptosis Regulator BclX or BCLX or BCL2L1) pipeline drugs market research report provides comprehensive information on the Bcl 2 Like Protein 1 (Apoptosis Regulator BclX or BCLX or BCL2L1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also reviews key players involved in Bcl 2 Like Protein 1 (Apoptosis...
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Neuronal Acetylcholine Receptor Subunit Alpha 7 (CHRNA7) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Neuronal acetylcholine receptor subunit alpha-7 is a protein encoded by the CHRNA7 gene. The Neuronal Acetylcholine Receptor Subunit Alpha 7 (CHRNA7) pipeline drugs market research report provides comprehensive information on the Neuronal Acetylcholine Receptor Subunit Alpha 7 (CHRNA7) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also reviews key players involved in Neuronal Acetylcholine Receptor Subunit Alpha 7 (CHRNA7) targeted therapeutics development with respective active...
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Non Receptor Tyrosine Protein Kinase TYK2 (TYK2 or EC 2.7.10.2) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Non-receptor tyrosine-protein kinase TYK2 is an enzyme encoded by the TYK2 gene. The Non Receptor Tyrosine Protein Kinase TYK2 (TYK2 or EC 2.7.10.2) pipeline drugs market research report provides comprehensive information on the Non Receptor Tyrosine Protein Kinase TYK2 (TYK2 or EC 2.7.10.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also reviews key players involved in Non Receptor Tyrosine Protein Kinase TYK2 (TYK2 or...
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RAF Proto Oncogene Serine, Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
RAF proto-oncogene serine/threonine-protein kinase or proto-oncogene c-RAF is an enzyme encoded by the RAF1 gene. The RAF Proto Oncogene Serine, Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1) pipeline drugs market research report provides comprehensive information on the RAF Proto Oncogene Serine/Threonine Protein Kinase (Proto Oncogene c RAF or RAF1 or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report...
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Respiratory Syncytial Virus Attachment Glycoprotein (RSV G or G) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Respiratory syncytial virus G protein is a protein produced by the respiratory syncytial virus. The Respiratory Syncytial Virus Attachment Glycoprotein (RSV G or G) pipeline drugs market research report provides comprehensive information on the Respiratory Syncytial Virus Attachment Glycoprotein (RSV G or G) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also reviews key players involved in Respiratory Syncytial Virus Attachment Glycoprotein (RSV G or...
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Sodium and Chloride Dependent Glycine Transporter 1 (Glyt1 or Solute Carrier Family 6 Member 9 or SLC6A9) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Sodium and chloride dependent glycine transporter 1 is a protein encoded by the SLC6A9 gene. The Sodium and Chloride Dependent Glycine Transporter 1 (Glyt1 or Solute Carrier Family 6 Member 9 or SLC6A9) pipeline drugs market research report provides comprehensive information on the Sodium and Chloride Dependent Glycine Transporter 1 (Glyt1 or Solute Carrier Family 6 Member 9 or SLC6A9) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule...
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Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 2.7.10.2) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Tyrosine-protein kinase CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune response. The Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 2.7.10.2) pipeline drugs market research report provides comprehensive information on the Tyrosine Protein Kinase CSK (C Src Kinase or Protein Tyrosine Kinase CYL or CSK or EC 2.7.10.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration...
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Wilson Disease Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Wilson disease is a rare autosomal recessive inherited disorder of copper metabolism that is characterized by excessive deposition of copper in the liver, brain, and other tissues. Symptoms include abdominal pain, jaundice, problems with speech and swallowing, and muscle stiffness. Treatment includes chelators and Vitamin E supplements. The Wilson disease pipeline market research report provides comprehensive information on the therapeutics under development for Wilson disease, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of...
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