Alcoholic Hepatitis Marketed and Pipeline Drugs Assessment, Clinical Trials and Competitive Landscape

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Published: July 23, 2024 Report Code: GDHC167CL-ST

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Alcoholic Hepatitis Marketed and Pipeline Drugs Report Overview

Alcoholic hepatitis (AH) is characterized by a rapid onset of jaundice and liver‐related complications in patients with excessive alcohol use, and it has a high short‐term mortality. The liver is the primary site of ethanol metabolism and sustains the greatest degree of tissue injury by heavy drinking. AH is the result of the complex interplay between ethanol metabolism, inflammation, and innate immunity.

The series of events involved in AH pathogenesis include alcohol-induced hepatocyte damage, reactive oxygen species, and gut-derived microbial components that result in steatosis and inflammatory cell recruitment and activation in the liver.

Key Mechanisms of Action (Marketed) ·       Receptor Agonist

·       Ligand Depletor

·       Receptor Antagonist
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The alcoholic hepatitis marketed and pipeline drugs market research report includes an assessment of the disease epidemiology, leading marketed products with sales forecast, and pricing and reimbursement of therapy in major countries. Furthermore, the report analyzes late-to-mid-stage pipeline products with Phase Transition Success Rate (PTSR) and Likelihood of Approval (LoA) for alcoholic hepatitis.

The report also provides actionable insights into the clinical and commercial landscapes of AH, M&A deals, and market catalysts. These critical data will help you develop and design your in-licensing and out-licensing strategies. Furthermore, identify companies with the most robust pipelines to create smart business goals.

Key Mechanisms of Action (Pipeline) ·       Enzyme Inhibitor

·       Receptor Agonist

·       Receptor Antagonist

·       Genes, Nucleic Acids & Related Components Inhibitor

·       Biological Factor Inhibitor

·       Enzyme Activator
Key Molecule Types (Pipeline) ·       Small Molecule

·       Biologic

·       Oligonucleotide
Top Sponsors (Marketed and Pipeline Drugs) ·       Institute of Liver and Biliary Sciences

·       Postgraduate Institute of Medical Education and Research

·       Surrozen Inc

·       Imperial College of London

·       Erasme Hospital
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Alcoholic Hepatitis Marketed Drugs Market Segmentation by Mechanisms of Action

The key MoA of the marketed drugs for alcoholic hepatitis includes receptor agonists, ligand depletors, and receptor antagonists. In 2024, most of the marketed drugs follow receptor agonist MoA in the AH market.

Alcoholic Hepatitis Marketed Drugs Market Analysis by Mechanisms of Action, 2024 (%)

Alcoholic Hepatitis Marketed Drugs Market Analysis by Mechanisms of Action, 2024 (%)

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Alcoholic Hepatitis Pipeline Drugs Market Segmentation by Mechanisms of Action

The key MoA of the drugs in the alcoholic hepatitis pipeline mainly includes enzyme inhibitors; receptor agonists; receptor antagonists; genes, nucleic acids & related components inhibitors; biological factor inhibitors; and enzyme activators. Most of the pipeline drugs for AH follow enzyme inhibitor MoA in 2024.

Alcoholic Hepatitis Pipeline Drugs Market Analysis by Mechanisms of Action, 2024 (%)

Alcoholic Hepatitis Pipeline Drugs Market Analysis by Mechanisms of Action, 2024 (%)

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Alcoholic Hepatitis Pipeline Drugs Market Segmentation by Molecule Types

In 2024, the leading molecule type for alcoholic hepatitis pipeline drugs is small molecules, followed by biologics. The other drugs currently in development are oligonucleotide types.

Alcoholic Hepatitis Pipeline Drugs Market Analysis by Molecule Types, 2024 (%)

Alcoholic Hepatitis Pipeline Drugs Market Analysis by Molecule Types, 2024 (%)

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Alcoholic Hepatitis Marketed and Pipeline Drugs Market – Competitive Landscape

A few of the top sponsors in the alcoholic hepatitis marketed and pipeline drugs market are the Institute of Liver and Biliary Sciences, Postgraduate Institute of Medical Education and Research, Surrozen Inc., Imperial College of London, and Erasme Hospital, among others. Institute of Liver and Biliary Sciences is sponsoring the highest number of trials in 2024.

Alcoholic Hepatitis Marketed and Pipeline Drugs Market Analysis by Sponsors, 2024 (%)

Alcoholic Hepatitis Marketed and Pipeline Drugs Market Analysis by Sponsors, 2024 (%)

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Segments Covered in the Report

Alcoholic Hepatitis Marketed Drugs Mechanisms of Action Outlook (2024)

  • Receptor Agonist
  • Ligand Depletory
  • Receptor Antagonist

Alcoholic Hepatitis Pipeline Drugs Mechanisms of Action Outlook (2024)

  • Enzyme Inhibitor
  • Receptor Agonist
  • Receptor Antagonist
  • Genes, Nucleic Acids & Related Components Inhibitor
  • Biological Factor Inhibitor
  • Enzyme Activator

Alcoholic Hepatitis Pipeline Drugs Molecule Types Outlook (2024)

  • Small Molecule
  • Biologic
  • Oligonucleotide

Scope

The key components of the report include:

  • Disease Landscape

  • Disease Overview

  • Epidemiology Overview

  • Treatment Overview

  • Marketed Products Assessment

  • Breakdown by Mechanism of Action, Route of Administration

  • Product Profiles with Sales Forecast

  • Pricing and Reimbursement Assessment

  • Annual Therapy Cost

  • Time to Pricing and Time to Reimbursement

  • Pipeline Assessment

  • Breakdown by Development Stage, Mechanism of Action, Molecule Type, Route of Administration

  • Product Profiles with Sales Forecast

  • Late-to-mid-stage Pipeline Drugs

  • Phase Transition Success Rate and Likelihood of Approval

  • Clinical Trials Assessment

  • Breakdown of Trials by Phase, Status, Virtual Components, Sponsors, Geography, and Endpoint Status

  • Enrolment Analytics, Site Analytics, Feasibility Analysis

  • Deals Landscape

  • Mergers, Acquisitions, and Strategic Alliances by Region

  • Overview of Recent Deals

  • Commercial Assessment

  • Key Market Players

  • Future Market Catalysts

Reasons to Buy

  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.

  • Develop business strategies by understanding the trends shaping and driving the Alcoholic Hepatitis market.

  • Drive revenues by understanding the key trends, innovative products and technologies, and companies likely to impact the global Alcoholic Hepatitis market in the future.

  • Formulate effective sales and marketing strategies by understanding the competitive landscape and analyzing the performance of various competitors.

  • Identify emerging players with potentially strong product portfolios and create effective counterstrategies to gain a competitive advantage.

  • Organize your sales and marketing efforts by identifying the market categories that present the maximum opportunities for consolidations, investments, and strategic partnerships.

Table of Contents

1 Table of Contents (PowerPoint Deck)

1 Preface

1.1 Contents

1.2 Report Scope

1.3 List of Tables and Figures

1.4 Abbreviations

2 Key Findings

3 Disease Landscape

3.1 Disease Overview

3.2 Epidemiology Overview

3.3 Treatment Overview

4 Marketed Drugs Assessment

4.1 Leading Marketed Drugs

4.2 Overview by Mechanism of Action

4.3 Overview by Molecule Type

4.4 Product Profiles and Sales Forecast

5 Pricing and Reimbursement Assessment

5.1 Annual Cost of Therapy

5.2 Time to Pricing and Reimbursement

6 Pipeline Drugs Assessment

6.1 Mid-to-late-stage Pipeline Drugs

6.2 Overview by Development Stage

6.3 Overview by Mechanism of Action

6.4 Overview by Molecule Type

6.5 Drug Specific Phase Transition Success Rate (PTSR) and Likelihood of Approval (LoA)

6.6 Therapy Area and Indication-specific PTSR and LoA

7 Clinical Trials Assessment

7.1 Historical Overview

7.2 Overview by Phase

7.3 Overview by Status

7.4 Overview by Phase for Ongoing and Planned Trials

7.5 Trials with Virtual Components

7.6 Overview of Trials by Geography

7.7 Single-Country and Multinational Trials by Region

7.8 Top 20 Sponsors with Breakdown by Phase

7.9 Top 20 Sponsors with Breakdown by Status

7.10 Overview by Endpoint Status

7.11 Overview by Race and Ethnicity

7.12 Enrollment Data

7.13 Top 20 countries for Trial Sites

7.14 Top 20 Sites Globally

7.15 Feasibility Analysis – Geographic Overview

7.16 Feasibility Analysis – Benchmark Models

8 Deals Landscape

8.1 Mergers, Acquisitions, and Strategic Alliances by Region

8.2 Recent Mergers, Acquisitions, and Strategic Alliances

9 Commercial Assessment

9.1 Key Market Players

10 Future Market Catalysts

11 Appendix

11.1 Methodology

11.2 Methodology – Sales Forecast

11.3 Methodology – Pricing and Reimbursement

11.4 Methodology – PTSR and LoA Analysis

11.5 About the Authors

11.6 Contact Us

11.7 Disclaimer

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