Arthroscopy Devices – Medical Devices Pipeline Assessment, 2020

1 Table of Contents 2

1.1 List of Tables 4

1.2 List of Figures 5

2 Introduction 6

2.1 Arthroscopy Overview 6

3 Products under Development 8

3.1 Arthroscopy – Pipeline Products by Stage of Development 8

3.2 Arthroscopy – Pipeline Products by Segment 9

3.3 Arthroscopy – Pipeline Products by Territory 10

3.4 Arthroscopy – Pipeline Products by Regulatory Path 11

3.5 Arthroscopy – Pipeline Products by Estimated Approval Date 12

3.6 Arthroscopy – Ongoing Clinical Trials 13

4 Arthroscopy – Pipeline Products under Development by Companies 14

4.1 Arthroscopy Companies – Pipeline Products by Stage of Development 14

4.2 Arthroscopy – Pipeline Products by Stage of Development 15

5 Arthroscopy Companies and Product Overview 16

5.1 Anika Therapeutics Inc Company Overview 16

5.1.1 Anika Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 16

5.2 Arthroscopic Innovations LLC Company Overview 17

5.2.1 Arthroscopic Innovations LLC Pipeline Products & Ongoing Clinical Trials Overview 17

5.3 CartiHeal Ltd Company Overview 18

5.3.1 CartiHeal Ltd Pipeline Products & Ongoing Clinical Trials Overview 18

5.4 Cartimage Medical SAS Company Overview 21

5.4.1 Cartimage Medical SAS Pipeline Products & Ongoing Clinical Trials Overview 21

5.5 Clemson University Company Overview 24

5.5.1 Clemson University Pipeline Products & Ongoing Clinical Trials Overview 24

5.6 Cleveland Clinic Hospital Company Overview 25

5.6.1 Cleveland Clinic Hospital Pipeline Products & Ongoing Clinical Trials Overview 25

5.7 Elite Surgical Supplies (Pty) Ltd Company Overview 26

5.7.1 Elite Surgical Supplies (Pty) Ltd Pipeline Products & Ongoing Clinical Trials Overview 26

5.8 Hospital for Special Surgery Company Overview 27

5.8.1 Hospital for Special Surgery Pipeline Products & Ongoing Clinical Trials Overview 27

5.9 MinInvasive Ltd. Company Overview 29

5.9.1 MinInvasive Ltd. Pipeline Products & Ongoing Clinical Trials Overview 29

5.10 NanoSurgery Technology Corp Company Overview 30

5.10.1 NanoSurgery Technology Corp Pipeline Products & Ongoing Clinical Trials Overview 30

5.11 Naviswiss AG Company Overview 31

5.11.1 Naviswiss AG Pipeline Products & Ongoing Clinical Trials Overview 31

5.12 Orthocrafts Innovations Pvt Ltd Company Overview 32

5.12.1 Orthocrafts Innovations Pvt Ltd Pipeline Products & Ongoing Clinical Trials Overview 32

5.13 Pro-Dex Inc Company Overview 33

5.13.1 Pro-Dex Inc Pipeline Products & Ongoing Clinical Trials Overview 33

5.14 Sheba Medical Center Company Overview 35

5.14.1 Sheba Medical Center Pipeline Products & Ongoing Clinical Trials Overview 35

5.15 SpineSmith Holdings LLC Company Overview 36

5.15.1 SpineSmith Holdings LLC Pipeline Products & Ongoing Clinical Trials Overview 36

5.16 Ti-TaMed (PTY) LTD. Company Overview 37

5.16.1 Ti-TaMed (PTY) LTD. Pipeline Products & Ongoing Clinical Trials Overview 37

5.17 Trice Medical Inc Company Overview 38

5.17.1 Trice Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 38

5.18 University of Florida Company Overview 39

5.18.1 University of Florida Pipeline Products & Ongoing Clinical Trials Overview 39

5.19 University of Utah Company Overview 40

5.19.1 University of Utah Pipeline Products & Ongoing Clinical Trials Overview 40

6 Arthroscopy- Recent Developments 41

6.1 Nov 23, 2020: Picosun, Chinese hospitals partner on medical technology for safer surgeries 41

6.2 Nov 02, 2020: Fraunhofer IFAM develops twofold infection protection for implants 41

6.3 Oct 27, 2020: Episealer publication available online 43

6.4 Sep 16, 2020: NPPA extends the ceiling prices of orthopaedic knee implants for another year 43

6.5 Sep 09, 2020: Episurf Medical: Strong long-term data 43

6.6 Aug 20, 2020: Conformis Announces achievement of second milestone under development and license agreements 44

6.7 Jul 28, 2020: Impressio and MedShape awarded competitive grant from the National Science Foundation to develop joint replacement device 44

6.8 Jul 07, 2020: NUST MISIS Scientists develop a biodegradable alloy for bone implants 45

6.9 Jun 29, 2020: DePuy Synthes renews cooperation agreement with AO Foundation to continue advancement of surgical education 45

6.10 May 28, 2020: Conformis announces settlement of patent dispute 46

6.11 Mar 04, 2020: Medacta announces FDA clearance for multiple sports medicine products: MectaLock All-Suture Anchors, MectaTap Ti Suture Anchors and MectaFIX CL 46

6.12 Mar 03, 2020: Implanet steps up development in Germany and consolidates its organization 47

6.13 Mar 02, 2020: Stryker announces new Investor Relations leader 47

6.14 Feb 25, 2020: Stryker announces nomination of new Director, Lisa Skeete Tatum 48

6.15 Feb 24, 2020: 2020 Catalyst award winner Medtronic hires Chief Inclusion and Diversity Officer 48

6.16 Feb 24, 2020: 2020 Catalyst Award Winner Medtronic hires Chief Inclusion and Diversity Officer 49

6.17 Feb 18, 2020: Medtronic reports third quarter financial results 2020 49

6.18 Feb 18, 2020: NN appoints Warren Veltman as president and CEO 52

6.19 Feb 13, 2020: Precision Optics reports second quarter fiscal year 2020 financial results 52

6.20 Feb 07, 2020: Episurf Medical:Year-end report 1 October – 31 December 2019 53

6.21 Feb 05, 2020: Stryker expands Flower Mound regional headquarters 53

6.22 Feb 04, 2020: Zimmer Biomet announces fourth quarter and full-year 2019 financial results 54

6.23 Jan 28, 2020: Merit Medical launches Arcadia Steerable and Straight Balloons 54

6.24 Jan 28, 2020: Stryker reports 2019 results and 2020 outlook 55

6.25 Jan 23, 2020: Medacta announces several first-time surgeries and CE marking for multiple products for its Sports Medicine Division 56

6.26 Jan 23, 2020: Brainlab acquires San Diego-based VisionTree Software 57

6.27 Jan 13, 2020: Apyx Medical reports preliminary full year and fourth quarter 2019 revenue results 58

6.28 Jan 08, 2020: Zimmer Biomet appoints Keri P. Mattox as Senior Vice President of Investor Relations and Chief Communications Officer 59

6.29 Dec 31, 2019: NN hires Christina Carroll and Tom Wilson to board of directors 59

6.30 Dec 12, 2019: BRAIN AG publishes preliminary results for the financial year 2018/19 60

6.31 Dec 09, 2019: CartiHeal announces positive interim analysis results of Agili-C IDE Study 61

6.32 Dec 04, 2019: Lumeon and Medtronic partner to deliver new models of care in Europe 62

6.33 Dec 03, 2019: Precision Optics announces promotion of Daniel Habhegger to CFO 63

7 Appendix 64

7.1 Methodology 64

7.2 About GlobalData 68

7.3 Contact Us 68

Table 1: Arthroscopy – Pipeline Products by Stage of Development 8

Table 2: Arthroscopy – Pipeline Products by Segment 9

Table 3: Arthroscopy – Pipeline Products by Territory 10

Table 4: Arthroscopy – Pipeline Products by Regulatory Path 11

Table 5: Arthroscopy – Pipeline Products by Estimated Approval Date 12

Table 6: Arthroscopy – Ongoing Clinical Trials 13

Table 7: Arthroscopy Companies – Pipeline Products by Stage of Development 14

Table 8: Arthroscopy – Pipeline Products by Stage of Development 15

Table 9: Anika Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 16

Table 10: Interference Screw – Product Status 16

Table 11: Interference Screw – Product Description 16

Table 12: Arthroscopic Innovations LLC Pipeline Products & Ongoing Clinical Trials Overview 17

Table 13: Intersector – Product Status 17

Table 14: Intersector – Product Description 17

Table 15: CartiHeal Ltd Pipeline Products & Ongoing Clinical Trials Overview 18

Table 16: Agili-C Cylindrical Implant – Product Status 18

Table 17: Agili-C Cylindrical Implant – Product Description 18

Table 18: CartiHeal Ltd – Ongoing Clinical Trials Overview 19

Table 19: Agili-C Cylindrical Implant – A Prospective Multicenter Open-label Randomized Controlled Trial of Agili-C Versus Surgical Standard of Care (SSOC) for the Treatment of Joint Surface Lesions of the Knee 20

Table 20: Cartimage Medical SAS Pipeline Products & Ongoing Clinical Trials Overview 21

Table 21: Arthroscopic Imaging Probe – Meniscal Repair – Product Status 21

Table 22: Arthroscopic Imaging Probe – Meniscal Repair – Product Description 21

Table 23: Arthroscopic Imaging Probe – Shoulder Arthroscopy – Product Status 22

Table 24: Arthroscopic Imaging Probe – Shoulder Arthroscopy – Product Description 22

Table 25: Arthroscopic Imaging Probe – Thoracoscopy – Product Status 22

Table 26: Arthroscopic Imaging Probe – Thoracoscopy – Product Description 23

Table 27: Clemson University Pipeline Products & Ongoing Clinical Trials Overview 24

Table 28: Insita Pro – Product Status 24

Table 29: Insita Pro – Product Description 24

Table 30: Cleveland Clinic Hospital Pipeline Products & Ongoing Clinical Trials Overview 25

Table 31: Elbow Implant – Product Status 25

Table 32: Elbow Implant – Product Description 25

Table 33: Elite Surgical Supplies (Pty) Ltd Pipeline Products & Ongoing Clinical Trials Overview 26

Table 34: Elite Arthroscopy Viewing Portal – Product Status 26

Table 35: Elite Arthroscopy Viewing Portal – Product Description 26

Table 36: Hospital for Special Surgery Pipeline Products & Ongoing Clinical Trials Overview 27

Table 37: Arthroscopic Surgery Tool – Product Status 27

Table 38: Arthroscopic Surgery Tool – Product Description 27

Table 39: Rotator Cuff Repair Patch – Product Status 28

Table 40: Rotator Cuff Repair Patch – Product Description 28

Table 41: MinInvasive Ltd. Pipeline Products & Ongoing Clinical Trials Overview 29

Table 42: OmniCuff – Product Status 29

Table 43: OmniCuff – Product Description 29

Table 44: NanoSurgery Technology Corp Pipeline Products & Ongoing Clinical Trials Overview 30

Table 45: NanoScope – Product Status 30

Table 46: NanoScope – Product Description 30

Table 47: Naviswiss AG Pipeline Products & Ongoing Clinical Trials Overview 31

Table 48: Naviswiss System – Knee Replacement – Product Status 31

Table 49: Naviswiss System – Knee Replacement – Product Description 31

Table 50: Orthocrafts Innovations Pvt Ltd Pipeline Products & Ongoing Clinical Trials Overview 32

Table 51: OsteoAnchor – Product Status 32

Table 52: OsteoAnchor – Product Description 32

Table 53: Pro-Dex Inc Pipeline Products & Ongoing Clinical Trials Overview 33

Table 54: Arthroscopic Attachment – Product Status 33

Table 55: Arthroscopic Attachment – Product Description 33

Table 56: Arthroscopic Shaver – Product Status 34

Table 57: Arthroscopic Shaver – Product Description 34

Table 58: Sheba Medical Center Pipeline Products & Ongoing Clinical Trials Overview 35

Table 59: Temporomandibular Joint Arthroscopy Guide Device – Product Status 35

Table 60: Temporomandibular Joint Arthroscopy Guide Device – Product Description 35

Table 61: SpineSmith Holdings LLC Pipeline Products & Ongoing Clinical Trials Overview 36

Table 62: Distraction Pin Aspiration Device – Product Status 36

Table 63: Distraction Pin Aspiration Device – Product Description 36

Table 64: Ti-TaMed (PTY) LTD. Pipeline Products & Ongoing Clinical Trials Overview 37

Table 65: Arthroscopic Device – Product Status 37

Table 66: Arthroscopic Device – Product Description 37

Table 67: Trice Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 38

Table 68: mi-eye 3 – Product Status 38

Table 69: mi-eye 3 – Product Description 38

Table 70: University of Florida Pipeline Products & Ongoing Clinical Trials Overview 39

Table 71: Shoulder Labral Anchor Delivery System – Product Status 39

Table 72: Shoulder Labral Anchor Delivery System – Product Description 39

Table 73: University of Utah Pipeline Products & Ongoing Clinical Trials Overview 40

Table 74: Distractor For Ankle and Subtalar Arthroscopy – Product Status 40

Table 75: Distractor For Ankle and Subtalar Arthroscopy – Product Description 40

Figure 1: Arthroscopy – Pipeline Products by Stage of Development 8

Figure 2: Arthroscopy – Pipeline Products by Segment 9

Figure 3: Arthroscopy – Pipeline Products by Territory 10

Figure 4: Arthroscopy – Pipeline Products by Regulatory Path 11

Figure 5: Arthroscopy – Pipeline Products by Estimated Approval Date 12