Clinical Trials Feasibility Risk Assessment and Planning for Success – A Depression Case Study

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This report provides the global clinical trial landscape for depression and identifies key analysis of the main features in order to run similar trials successfully.

As the prevalence of depression has increased, the outlook of it has also changed in positive ways. Better support and services for depression as well as the increase of discussing this order has lead to an increase of depression clinical trials. The COVID-19 pandemic has played a major role in that.

Scope

This report provides a review of global depression clinical trials derived from the GlobalData’s Clinical Trials Database and Feasibility Planner. The aim of this report is to provide analyses of these trials, coupled with analyses of what to expect when running a similar trial.

Key Highlights

1. COVID-19 pandemic has changed the landscape of depression clinical trials

2. Depression clinical trials are being ran all around the world, with North America having the most.

3. Top sponsors for depression trials are Eli Lilly and Massachusetts General Hospital.

4. The important of eliminating delays in depression clinical trials.

5. It is essential to select the right trial design, such as sites and investigators.

Reasons to Buy

Identifies and analyses depression clinical trials by multiple trial designs, such as trial start year, phase and virtual components.

Examines the effect of COVID-19 on depression trials

Gives reason for certain trends seen in depression trials

Uses the GlobalData's Feasibility Planner to help to improve trial planning

Comparison of enrollment parameters for different trials to an industry average

Provides analysis of best suited clinical trial sites and investigators for depression trials

Eli Lilly
Massachusetts General Hospital
CVS
Johnson & Johnson
GlaxoSmithKline

Table of Contents

1 Table and Figures

– List of Tables

– List of Figures

2 Executive Summary

3 Introduction

– Report Scope

– Methodology

4 Global Depression Clinical Trial Landscape

– 2021 Was the Leading Year in Depression Clinical Trials

– Phase I Has Dominated Depression Trials Since 2020

– Single-Country Tops Multinational for Depression Trials

– North America Has the Most Depression Clinical Trials

– Non-industry Sponsors Lead Overall in Depression Trials

– Eli Lilly Is the Top Industry Sponsor

– Massachusetts General Hospital Tops Non-industry Sponsors

– Phase IV Has the Longest Enrollment Period and Trial Duration

– Two-Thirds of Depression Trials Have Achieved Endpoint Status

– Decentralized Clinical Trial Used More in Depression Trials Due to the COVID-19 Pandemic

– Mobile Healthcare and Telemedicine Used the Most in Decentralized Clinical Trials

5 Feasibility Planner – A Depression Case Study

– Low Accrual Rate Is the Top Reason for Trial Termination in All Phases

– Enrollment Rate Higher in Industry Average Compared to Five Trials

– Number of Subjects and Sites Comparison of Five Trials to Industry Average

– US Also Has the Most Recommended Sites for Depression Trials

– Pennsylvania, US Is the Top Choice for Depression Clinical Trial Sites

– US Has the Most Recommended Investigators for Depression Trials

6 Key Findings

7 Appendix

– Abbreviations

– About the Authors

– About GlobalData

– Contact Us

Table

Table 1: Average Distance Travelled Between Top Five Sites for Depression Trials to the Top Five Sites by Disease Prevalence in the US

Figures

Figure 1: Number of Depression Clinical Trials, by Trial Start Year (2015–23)

Figure 2: Number of Depression Clinical Trials, by Trial Start Year and Phase

Figure 3: Number of Depression Clinical Trials by Phase, Single-Country Versus Multinational

Figure 4: Number of Depression Clinical Trials by Region and Phase

Figure 5: Number of Depression Clinical Trials by Phase, Industry Versus Non-industry

Figure 6: Depression Clinical Trials, by Top 10 Industry Sponsors

Figure 7: Depression Clinical Trials, by Top 10 Non-industry Sponsors

Figure 8: Projected Timelines for Depression Clinical Trials, by Phase

Figure 9: Endpoint Status for Depression Clinical Trials, by Phase

Figure 10: Number of Depression Trials Using Decentralized Virtual Components

Figures 11–12: Number of Depression Clinical Trials, by Virtual Components

Figure 13: Number of Depression Clinical Trials, by Trial Termination and Phase

Figure 14: Enrollment Rate Comparison

Figure 15: Number of Subjects and Sites Comparison

Figure 16: Top Recommended Sites for Depression Clinical Trials

Figure 17: Distance in Hours Between Top Five Sites for Depression Trials to the Top Five Sites by Disease Prevalence in the US

Figure 18: Top Recommended Investigator for Depression Clinical Trials

Frequently asked questions

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