Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

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Metabotropic glutamate receptor 5 (mGluR5) is a G protein-coupled receptor. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol calcium second messenger system and generates a calcium activated chloride current.

The Metabotropic Glutamate Receptor 5 pipeline drugs market research report provides comprehensive information on the therapeutics under development for Metabotropic Glutamate Receptor 5, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history, and the latest news and press releases. Additionally, the report reviews key players involved in therapeutic development for Metabotropic Glutamate Receptor 5 and features dormant and discontinued projects.

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Segmentation by Therapy Areas

The key therapy areas in the Metabotropic Glutamate Receptor 5 pipeline products market are Central Nervous System, Genetic Disorders, Ophthalmology, and Undisclosed.

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Therapy areas

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Therapy areas

For more target insights into the Metabotropic Glutamate Receptor 5 pipeline drugs market, download a free report sample

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Segmentation by Mechanism of Actions

The key mechanisms of action in the Metabotropic Glutamate Receptor 5 pipeline products market are Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 5 Agonist.

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Mechanisms of Action

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Mechanisms of Action

For more mechanisms of action insights into the Metabotropic Glutamate Receptor 5 pipeline drugs market, download a free report sample

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Segmentation by Routes of Administration

The key route of administration in the Metabotropic Glutamate Receptor 5 pipeline products market is oral.

Metabotropic Glutamate Receptor Pipeline Drugs Market Segmentation by Molecule Types

The different molecule type in the Metabotropic Glutamate Receptor 5 pipeline products market is small molecule and peptide.

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Molecule Types

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Molecule Types

For more molecule type insights into the Metabotropic Glutamate Receptor 5 pipeline drugs market, download a free report sample

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market - Competitive Landscape

The major companies in the Metabotropic Glutamate Receptor 5 pipeline products market are Addex Therapeutics Ltd, Allyx Therapeutics Inc, Appello Pharmaceuticals Inc, Bristol-Myers Squibb Co, Hua Medicine Shanghai Ltd, Laboratorio Farmaceutico CT Srl, and Lactocore Inc among others.

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Companies

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Analysis, by Companies

To know more about the companies in the Metabotropic Glutamate Receptor 5  pipeline drugs market, download a free report sample

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Report Overview

Key Therapy Areas Central Nervous System, Genetic Disorders, and Undisclosed
Key Mechanism of Actions Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 5 Agonist
Key Routes of Administration Oral
Key Molecule Types Small Molecule, and Peptide
Leading Companies Addex Therapeutics Ltd, Allyx Therapeutics Inc, Appello Pharmaceuticals Inc, Bristol-Myers Squibb Co, Hua Medicine Shanghai Ltd, Laboratorio Farmaceutico CT Srl, and Lactocore Inc

Segments Covered in the Report

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Therapy Areas Outlook

  • Central Nervous System
  • Genetic Disorders
  • Undisclosed

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Mechanism of Actions Outlook

  • Metabotropic Glutamate Receptor 5 Antagonist
  • Metabotropic Glutamate Receptor 5 Agonist

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Routes of Administration Outlook

  • Oral

Metabotropic Glutamate Receptor 5 Pipeline Drugs Market Molecule Types Outlook

  • Small Molecule
  • Peptide

Scope

  • The report provides a snapshot of the global therapeutic landscape for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5)
  • The report reviews Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) targeted therapeutics

Reasons to Buy

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Addex Therapeutics Ltd
Allyx Therapeutics Inc
Appello Pharmaceuticals Inc
Bristol-Myers Squibb Co
Hua Medicine Shanghai Ltd
Laboratorio Farmaceutico CT Srl
Lactocore Inc
Nobias Therapeutics Inc
Noema Pharma AG
Novartis AG
Park of Active Molecules
Tempero Bio

Table of Contents

Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Overview

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Therapeutics Development

Products under Development by Stage of Development

Products under Development by Therapy Area

Products under Development by Indication

Products under Development by Companies

Products under Development by Universities/Institutes

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Therapeutics Assessment

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Companies Involved in Therapeutics Development

Addex Therapeutics Ltd

Allyx Therapeutics Inc

Appello Pharmaceuticals Inc

Bristol-Myers Squibb Co

Hua Medicine Shanghai Ltd

Laboratorio Farmaceutico CT Srl

Lactocore Inc

Nobias Therapeutics Inc

Noema Pharma AG

Novartis AG

Park of Active Molecules

Tempero Bio

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Drug Profiles

alloswitch-1 – Drug Profile

Product Description

Mechanism Of Action

ALX-001 – Drug Profile

Product Description

Mechanism Of Action

History of Events

AP-612 – Drug Profile

Product Description

Mechanism Of Action

basimglurant – Drug Profile

Product Description

Mechanism Of Action

History of Events

BMS-952048 – Drug Profile

Product Description

Mechanism Of Action

dipraglurant – Drug Profile

Product Description

Mechanism Of Action

History of Events

dipraglurant ER – Drug Profile

Product Description

Mechanism Of Action

dipraglurant IR – Drug Profile

Product Description

Mechanism Of Action

History of Events

GET-73 – Drug Profile

Product Description

Mechanism Of Action

History of Events

HTL-0014242 – Drug Profile

Product Description

Mechanism Of Action

History of Events

LCGM-10 – Drug Profile

Product Description

Mechanism Of Action

mavoglurant – Drug Profile

Product Description

Mechanism Of Action

History of Events

mGLUR5 NAM – Drug Profile

Product Description

Mechanism Of Action

NB-001 – Drug Profile

Product Description

Mechanism Of Action

History of Events

PAM-12 – Drug Profile

Product Description

Mechanism Of Action

Small Molecules to Agonize mGluR5 for Schizophrenia – Drug Profile

Product Description

Mechanism Of Action

VU-0092273 – Drug Profile

Product Description

Mechanism Of Action

VU-0431316 – Drug Profile

Product Description

Mechanism Of Action

VU-0467558 – Drug Profile

Product Description

Mechanism Of Action

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Dormant Products

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Discontinued Products

Metabotropic Glutamate Receptor 5 (GPRC1E or MGLUR5 or GRM5) – Product Development Milestones

Featured News & Press Releases

Sep 06, 2022: Noema Pharma announces completion of enrollment in the Trigeminal Neuralgia Electronic Diary (TNED) validation study

Jun 17, 2022: Addex terminates dipraglurant phase 2b/3 study in patients with dyskinesia associated with Parkinson’s disease due to slow recruitment rate

May 27, 2022: Addex provides update on dipraglurant blepharospasm phase 2 feasibility clinical study

Apr 13, 2022: Addex Therapeutics completes patient enrollment for dipraglurant blepharospasm phase 2 clinical study

Feb 22, 2022: Noema Pharma announces first patient dosed in Phase 2b LibraTN study of mGluR5 inhibitor NOE-101 in trigeminal neuralgia

Feb 14, 2022: Noema Pharma announces FDA Investigational New Drug Authorization for Phase 2b LibraTN study of mGluR5 inhibitor NOE-101 in trigeminal neuralgia

Sep 29, 2021: Addex Therapeutics initiates phase 2 clinical study with Dipraglurant in blepharospasm

Jul 07, 2021: Noema Pharma to host a key opinion leader webinar on seizures in tuberous sclerosis complex

Jun 29, 2021: Addex Therapeutics initiates pivotal phase 2b/3 study with dipraglurant for dyskinesia associated with Parkinson’s Disease

May 17, 2021: Addex’s Dipraglurant restores synaptic plasticity in models of Dystonia

Mar 18, 2020: Addex Therapeutics delays start of Dipraglurant pivotal study and reporting 2019 full year audited results

Jan 17, 2019: Experimental drug improves eye gaze behavior in fragile X syndrome

Dec 13, 2018: Sosei Heptares starts new clinical development program – First subject dosed in Phase I study of HTL0014242, a selective mGlu5 negative allosteric modulator in development to treat psychiatric and neurological disorders

Oct 18, 2017: Van Leeuwenhoeck Issues Initiation of Coverage Research Report on Addex Therapeutics and Estimated ADXN Share Price of CHF

11.5 per Share

Feb 06, 2017: Addex’s Clinical Programs and Discovery Platform Highlighted in Review of Allosteric Modulators for the Treatment of Neurodegenerative Diseases

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

Table

List of Tables

Number of Products under Development by Stage of Development, 2022

Number of Products under Development by Therapy Areas, 2022

Number of Products under Development by Indications, 2022

Number of Products under Development by Indications, 2022 (Contd..1)

Number of Products under Development by Companies, 2022

Products under Development by Companies, 2022

Products under Development by Companies, 2022 (Contd..1)

Number of Products under Investigation by Universities/Institutes, 2022

Products under Investigation by Universities/Institutes, 2022

Number of Products by Stage and Mechanism of Actions, 2022

Number of Products by Stage and Route of Administration, 2022

Number of Products by Stage and Molecule Type, 2022

Pipeline by Addex Therapeutics Ltd, 2022

Pipeline by Allyx Therapeutics Inc, 2022

Pipeline by Appello Pharmaceuticals Inc, 2022

Pipeline by Bristol-Myers Squibb Co, 2022

Pipeline by Hua Medicine Shanghai Ltd, 2022

Pipeline by Laboratorio Farmaceutico CT Srl, 2022

Pipeline by Lactocore Inc, 2022

Pipeline by Nobias Therapeutics Inc, 2022

Pipeline by Noema Pharma AG, 2022

Pipeline by Novartis AG, 2022

Pipeline by Park of Active Molecules, 2022

Pipeline by Tempero Bio, 2022

Dormant Products, 2022

Dormant Products, 2022 (Contd..1)

Dormant Products, 2022 (Contd..2)

Dormant Products, 2022 (Contd..3)

Discontinued Products, 2022

Discontinued Products, 2022 (Contd..1)

Figures

List of Figures

Number of Products under Development by Stage of Development, 2022

Number of Products under Development by Therapy Areas, 2022

Number of Products under Development by Top 10 Indications, 2022

Number of Products by Mechanism of Actions, 2022

Number of Products by Stage and Mechanism of Actions, 2022

Number of Products by Stage and Route of Administration, 2022

Number of Products by Molecule Types, 2022

Number of Products by Stage and Molecule Types, 2022

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