Myelofibrosis Market Size, Drug Analysis, Epidemiology, Disease Management, Pipeline Assessment, Unmet Needs and Forecast to 2031

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Published: March 30, 2023 Report Code: GDHC269PIDR-ST

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Myelofibrosis Market Report Overview

The myelofibrosis market size was $2.39 billion across the 8MM in 2021 and will achieve a CAGR of more than 1% during 2021-2031. The approvals of several late-stage pipeline agents especially Vonjo and momelotinib and the continued strong performance of Jakafi/Jakavi in the first-line setting will drive market growth during the forecast period.

Myelofibrosis Market Outlook, 2021-2031 ($ Billion)

Myelofibrosis Market Outlook, 2021-2031 ($ Billion)

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The myelofibrosis market research covers the 8MM (the US, France, Germany, Italy, Spain, China, Japan, and the UK) and provides a forecast model for the myelofibrosis market through 2031.

Market Size (2021) $2.39 billion
CAGR (2021-2031) >1%
Key Class of Drugs (5EU) ·       JAK Inhibitors

·       Antimetabolities

·       ESAs

·       Glucocorticoids

·       Immunomodulatory Agents
Leading Players ·       Novartis

·       GSK

·       CTI

·       Zelgen

·       Abbvie
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Myelofibrosis Market Insights

The patent expiry of Jakafi/Jakavi is hampering the market growth. However, approvals of late-stage pipeline agents, including novel JAK inhibitors and targeted therapies, which will partially meet critical unmet clinical needs will propel the myelofibrosis market growth during the forecast period.

Myelofibrosis - Treatment Insights

  • In the US, there are three approved therapies for myelofibrosis including Incyte’s Jakafi (ruxolitinib) (approved 2011), BMS’s Inrebic (fedratinib) (approved 2019), and CTI BioPharma’s Vonjo (pacritinib) (approved 2022).
  • Vonjo and momelotinib are well-positioned to alleviate some of the unmet needs in MF, including providing improved treatment options for patients with low platelets and anemia respectively.

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Myelofibrosis Market Segmentation by Class of Drugs

In 2021, the leading global drug class myelofibrosis market in 5EU was JAK Inhibitors.

The key classes of drugs in the 5EU myelofibrosis market are JAK Inhibitors, Antimetabolities, ESAs, Glucocorticoids, and Immunomodulatory Agents. JAK inhibitors are generally used in higher-risk patients.

Myelofibrosis Market Analysis by Class of Drugs, 2021 (%)

Myelofibrosis Market Analysis by Class of Drugs, 2021 (%)

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Myelofibrosis Market - Competitive Landscape

 A few of the leading players in the myelofibrosis market are:

  • Novartis
  • GSK
  • CTI
  • Zelgen
  • Abbvie

Incyte was the first big pharma company to penetrate the MF market with its landmark approval of Jakafi/Jakavi in November 2011, becoming the first approved targeted agent for MF patients and subsequently achieving blockbuster status. Accordingly, Jakafi/Jakavi is one of Incyte’s most valuable assets, for which the commercial returns generated from the MF market share are still heavily relied upon by the company.

Myelofibrosis Market Analysis by Companies

Myelofibrosis Market Analysis by Companies

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Scope

  • Understand the epidemiology, symptoms, diagnosis, and management of myelofibrosis, to get a better overview of the market.

  • Annualized myelofibrosis market revenue, cost of therapy per patient, and treatment usage patterns forecast from 2021 to 2031.

  • Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping, and implications of these factors for the myelofibrosis therapeutics market.

  • Comprehensive data assessing emerging trends and mechanisms of action under development for myelofibrosis treatment. The most promising candidates in Phase III and Phase IIb development are profiled.

  • Analysis of the current and future market competition in the global myelofibrosis therapeutics market.

  • Insightful review of the key industry drivers, restraints, and challenges. Each trend is independently researched to provide a qualitative analysis of its implications.

Key Highlights

Report deliverables include a PowerPoint report and Excel-based forecast model

Forecasts includes the 8MM

Forecasts covers from 2021-2031

GlobalData valued the myelofibrosis market in the 8MM at $2.39 billion and expects the market to increase to $2.89 billion by 2031

Incyte, GSK and CTI BioPharma are expected to take market-leading position in 2031

A moderate level of unmet need will remain for most myelofibrosis patient populations during the forecast period

The late-stage pipeline in myelofibrosis is robust and is likely to provide significant clinical benefit to many myelofibrosis patient populations, with fierce competition expected

Reasons to Buy

  • Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.

  • Develop business strategies by understanding the trends shaping and driving the 7MM myelofibrosis therapeutics market.

  • Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the 7MM myelofibrosis therapeutics market in the future.

  • Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.

  • Identify emerging players with potentially strong product portfolios and create effective counterstrategies to gain a competitive advantage.

  • Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships.

Abbvie
Acceleron Pharma
Bristol Myers Squibb
Constellation Pharmaceuticals
CTI BioPharma
Geron
GSK
Hangzhou Bangshun Pharmaceutical
Huadong Medicine
Impact Biomedicines
Incyte
Kartos Therapeutics
Morphosys
Novartis
Sierra Oncology
Suzhou Zelgen Pharmaceuticals

Table of Contents

1 Myelofibrosis: Executive Summary

1.2 Novel JAK inhibitors and combination therapies will provide more holistic and robust treatment for myelofibrosis patients, including underserved patient populations

1.3 The level of unmet clinical need in myelofibrosis remains high during the forecast period, despite dramatic improvements by historical standards

1.4 The myelofibrosis pipeline is robust, with plenty of room for new market entrants

1.5 What do physicians think?

2 Introduction

2.1 Catalyst

2.2 Related reports

2.3 Upcoming reports

3 Disease Overview

3.1 Etiology and pathophysiology

3.1.1 Etiology

3.1.2 Pathophysiology

3.1.3 Classification and staging systems

4 Epidemiology

4.1 Disease background

4.2 Risk factors and comorbidities

4.3 Global and historical trends

4.4 Forecast methodology

4.4.1 Sources

4.4.2 Forecast assumptions and methods

4.4.3 Diagnosed incident cases of PMF

4.4.4 Diagnosed incident cases of PET MF and PPV MF

4.4.5 MIPSS70+ V2.0 risk categories among diagnosed PMF incident cases

4.4.6 Mutations among the diagnosed incident cases of PMF

4.4.7 Patients with/without anemia among the diagnosed incident cases of PMF

4.4.8 Diagnosed prevalent cases of PMF

4.4.9 Diagnosed prevalent cases of PET MF and PPV MF

4.5 Epidemiological forecast of myelofibrosis (2021-31)

4.5.1 Diagnosed incident cases of PMF

4.5.2 Age-specific diagnosed incident cases of PMF

4.5.3 Sex-specific diagnosed incident cases of PMF

4.5.4 Diagnosed incident cases of PMF by MIPSS70+ V2.0 risk category

4.5.5 Diagnosed incident cases of PMF by mutation

4.5.6 Patients with or without anemia among diagnosed incident cases of PMF

4.5.7 Diagnosed incident cases of PET MF

4.5.8 Sex-specific diagnosed incident cases of PET MF

4.5.9 Diagnosed incident cases of PPV MF

4.5.10 Sex-specific diagnosed incident cases of PPV MF

4.5.11 Diagnosed prevalent cases of PMF

4.5.12 Age-specific diagnosed prevalent cases of PMF

4.5.13 Sex-specific diagnosed prevalent cases of PMF

4.5.14 Diagnosed prevalent cases of PET MF

4.5.15 Sex-specific diagnosed prevalent cases of PET MF

4.5.16 Diagnosed prevalent cases of PPV MF

4.5.17 Sex-specific diagnosed prevalent cases of PPV MF

4.6 Discussion

4.6.1 Epidemiological forecast insight

4.6.2 COVID-19 impact

4.6.3 Limitations of the analysis

4.6.4 Strengths of the analysis

5 Disease Management

5.1 Diagnosis and Treatment Overview

5.2 KOL insights on disease management

5.2.1 Allogeneic hematopoietic cell transplant

5.2.2 Treatment for splenomegaly and constitutional symptoms

5.2.3 Treatment for anemia

5.2.4 US-specific KOL insights on disease management

5.2.5 EU-specific KOL Insights on Disease Management

5.2.6 China- and Japan-specific KOL insights on disease management

6 Current Treatment Options

6.1 Overview

7 Unmet Needs and Opportunity Assessment

7.1 Overview

7.2 Controlling anemia in patients on ruxolitinib

7.3 Improving the Durability of Treatments

7.4 Drugs that target disease progression and improve survival

7.5 More patients are needed for clinical trials

7.6 More Therapies for Patients with Thrombocytopenia

8 R&D Strategies

8.1 Overview

8.1.1 Novel JAK inhibitors

8.1.2 Combination Therapies

8.1.3 Monotherapies

8.2 Clinical trials design

8.2.1 Primary and secondary endpoints of pivotal trials

8.2.2 Study inclusion and exclusion criteria

8.2.3 Future directions for myelofibrosis clinical trials

9 Pipeline Assessment

9.1 Overview

9.2 Promising drugs in clinical development

10 Pipeline Valuation Analysis

10.1 Overview

10.2 Competitive assessment

11 Current and Future Players

11.1 Overview

11.2 Deal-making trends

12 Market Outlook

12.1 Global Markets

12.1.1 Forecast

12.1.2 Drivers and barriers – global issues

12.2 US

12.2.1 Forecast

12.2.2 Key events

12.2.3 Drivers and barriers

12.3 5EU

12.3.1 Forecast

12.3.2 Key events

12.3.3 Drivers and barriers

12.4 Japan

12.4.1 Forecast

12.4.2 Key events

12.4.3 Drivers and barriers

12.5 China

12.5.1 Forecast

12.5.2 Key events

12.5.3 Drivers and barriers

13 Appendix

13.1 Bibliography

13.2 Abbreviations

13.3 Methodology

13.3.1 Forecasting methodology

13.4 Primary research – KOLs interviewed for this report

13.4.1 KOLs

13.5 Primary research – prescriber survey

13.6 About the authors

13.6.1 Analyst

13.6.2 Therapy Area Director

13.6.3 Epidemiologist

13.6.4 Managing Epidemiologist

13.6.5 Global Director of Therapy Analysis and Epidemiology

13.6.6 Global Head and EVP of Healthcare Operations and Strategy

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Table

Table 1: Myelofibrosis: key metrics in the 8MM

Table 2: Risk factors for PMF patient survival scoring systems

Table 3: Risk factors and comorbid conditions associated with MF

Table 4: 8MM, diagnosed incident cases of PMF by MIPSS70+ v2.0 risk category, N, men and women, ages ≥40 years, 2021

Table 5: treatment guidelines for myelofibrosis across the 8MM

Table 6: Comparison of the efficacies of marketed JAK inhibitors

Table 8: Top 10 deals by value, 2017-22

Table 9: Myelofibrosis market – global drivers and barriers, 2021-31

Table 10: Key events impacting sales for myelofibrosis in the US, 2021-2031

Table 11: Myelofibrosis market – drivers and barriers in the US, 2021-2031

Table 12: Key events impacting sales for myelofibrosis in the 5EU, 2021-31

Table 13: Myelofibrosis market – drivers and barriers in the 5EU, 2021-31

Table 14: Key events impacting sales for myelofibrosis in Japan, 2021-31

Table 15: Myelofibrosis market – drivers and barriers in Japan, 2021-31

Table 16: Key events impacting sales for myelofibrosis in China, 2021-31

Table 17: Myelofibrosis market – drivers and barriers in China, 2021-31

Table 18: High-prescribing physicians (non-KOLs) surveyed, by country

Figures

Figure 1: Global sales forecast by country for myelofibrosis in 2021 and 2031

Figure 2: Analysis of the company portfolio gap in myelofibrosis during the forecast period

Figure 3: Competitive assessment of the late-stage monotherapy pipeline agents that GlobalData expects to be licensed for the treatment of myelofibrosis during the forecast period

Figure 4: Competitive assessment of the late-stage combination pipeline agents that GlobalData expects to be licensed for the treatment of myelofibrosis during the forecast period

Figure 5: JAK/STAT signaling in myelofibrosis

Figure 6: 8MM, diagnosed incidence of PMF (cases per 100,000 population), men and women, ages ≥40 years, 2021

Figure 7: 8MM, diagnosed prevalence of PMF (%), men and women, ages ≥40 years, 2021

Figure 8: 8MM, sources used and not used to forecast the diagnosed incident cases of PMF

Figure 9: 8MM, sources used to forecast the diagnosed incident cases of PET MF and PPV MF

Figure 10: 8MM, sources used to forecast the diagnosed incident cases of PMF by MIPSS70+ v2.0 risk categories

Figure 11: 8MM, sources used to forecast the diagnosed incident cases of PMF by JAK2V617F mutation

Figure 12: 8MM, sources used to forecast the diagnosed incident cases of PMF by CALR mutation

Figure 13: 8MM, sources used to forecast the diagnosed incident cases of PMF by MPL mutation

Figure 14: 8MM, sources used to forecast the diagnosed incident cases of PMF by anemia

Figure 15: 8MM, sources used to forecast the diagnosed prevalent cases of PMF

Figure 16: 8MM, sources used to forecast the diagnosed prevalent cases of PET MF and PPV MF

Figure 17: 8MM, diagnosed incident cases of PMF, N, men and women, ages ≥40 years, 2021

Figure 18: 8MM, diagnosed incident cases of PMF by age, N, men and women, 2021

Figure 19: 8MM, diagnosed incident cases of PMF by sex, N, ages ≥40 years, 2021

Figure 20: 8MM, diagnosed incident cases of PMF by mutation, N, men and women, ages ≥40 years, 2021

Figure 21: 8MM, patients with or without anemia among diagnosed incident cases of PMF, N, men and women, ages ≥40 years, 2021

Figure 22: 8MM, diagnosed incident cases of PET MF, N, men and women, ages ≥40 years, 2021

Figure 23: 8MM, diagnosed incident cases of PET MF by sex, N, ages ≥40 years, 2021

Figure 24: 8MM, diagnosed incident cases of PPV MF, N, men and women, ages ≥40 years, 2021

Figure 25: 8MM, diagnosed incident cases of PPV MF by sex, N, ages ≥40 years, 2021

Figure 26: 8MM, diagnosed prevalent cases of PMF, N, men and women, ages ≥40 years, 2021

Figure 27: 8MM, diagnosed prevalent cases of PMF by age, N, men and women, 2021

Figure 28: 8MM, diagnosed prevalent cases of PMF by sex, N, ages ≥40 years, 2021

Figure 29: 8MM, diagnosed prevalent cases of PET MF, N, men and women, ages ≥40 years, 2021

Figure 30: 8MM, diagnosed prevalent cases of PET MF by sex, N, ages ≥40 years, 2021

Figure 31: 8MM, diagnosed prevalent cases of PPV MF, N, men and women, ages ≥40 years, 2021

Figure 32: 8MM, diagnosed prevalent cases of PPV MF by sex, N, ages ≥40 years, 2021

Figure 33: Treatment algorithm for myelofibrosis-associated anemia

Figure 34: Treatment algorithm for splenomegaly and constitutional symptoms

Figure 35: Unmet needs and opportunities in myelofibrosis

Figure 36: Overview of the development pipeline in myelofibrosis

Figure 37: Key late-stage trials for the promising pipeline agents that GlobalData expects be licensed for myelofibrosis in the 8MM during the forecast period

Figure 38: Competitive assessment of the marketed and pipeline drugs benchmarked against the standard of care, Jakafi/Jakavi

Figure 39: Competitive assessment of the Jakafi/Jakavi combination therapies

Figure 40: Analysis of the company portfolio gap in myelofibrosis during the forecast period

Figure 41: Global (8MM) sales forecast by country for myelofibrosis in 2021 and 2031

Figure 42: Sales forecast by class for myelofibrosis in the US in 2021 and 2031

Figure 43: Sales forecast by class for myelofibrosis in the 5EU in 2021 and 2031

Figure 44: Sales forecast by class for myelofibrosis in Japan in 2021 and 2031

Figure 45: Sales forecast by class for myelofibrosis in China in 2021 and 2031

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