OpportunityAnalyzer: B-Cell Non-Hodgkin’s Lymphoma (NHL) – Opportunity Analysis and Forecasts to 2024
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Non-Hodgkin’s lymphoma (NHL) comprises a heterogeneous group of lymphoproliferative malignancies that arise in the B cells, T cells, or natural killer (NK) cells within the lymphoid tissue, such as the lymph nodes, bone marrow, thymus, and spleen. NHLs are further categorized into indolent or aggressive prognostic subtypes, which further influence the outcomes and treatment decisions. Patients diagnosed with indolent NHLs (follicular lymphoma [FL] or marginal zone lymphoma [MZL]) can achieve a median survival of 10 to 20 years, and relative 10-year survival rates of over 60%. However, patients with aggressive NHLs (diffuse large B-cell lymphoma [DLBCL] or mantle cell lymphoma [MCL]) can generally expect lower median survival rates, with the relative 10-year survival reported to be less than 50%.
For the purposes of this report, GlobalData focuses on the four most prevalent B-cell NHL subtypes: FL, MZL, DLBCL and MCL. The global market is defined to include sales of drugs aimed at treatment of those four subtypes in patients 30 years and older across the 7MM, which is comprised of the US, 5EU (France, Germany, Italy, Spain, and the UK), and Japan. The forecast includes the sale of agents in first-line, relapsed/refractory, and maintenance settings. GlobalData anticipates a major driver of market growth to be the steady increase in uptake of Imbruvica to treat MCL, and its anticipated expansion into FL, MZL, and DLBCL treatment settings over the forecast period.
Overview of NHL, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and current treatment options.
Topline NHL drug market revenue from 2014–2024. Annual cost of therapy (ACOT) and major product sales in first-line, relapsed/refractory, and maintenance treatment settings during the forecast period are included.
Key topics covered include strategic competitor assessment, market characterization, unmet needs, opportunities, and R&D strategies for the NHL market.
Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, synopses of innovative early-stage projects, and detailed analysis of late-stage pipeline products. An interactive clinical and commercial analyzer tool is available.
Analysis of the current and future market competition in the global NHL market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Based on interviews with key opinion leaders (KOLs), GlobalData has identified the major unmet needs in the NHL marketplace. Will the leading pipeline agents fulfil these unmet needs during the forecast period (2014–2024)?
What research and development (R&D) strategies will companies leverage to compete in the future NHL marketplace?
Which pipeline products are poised to make a major clinical and commercial impact?
What clinical and commercial factors are likely to influence NHL drug uptake in the US and 5EU (France, Germany, Italy, Spain, and the UK) and Japan (7MM)?
Table of Contents
1Table of Contents
1.1List of Tables
1.2List of Figures
3.1Etiology and Pathophysiology
3.1.1Pathophysiology of Indolent and Aggressive B-Cell NHL
4.2.2Marginal Zone Lymphoma
4.2.3Diffuse Large B-Cell Lymphoma
4.2.4Mantle Cell Lymphoma
4.3.2Marginal Zone Lymphoma
4.3.3Diffuse Large B-Cell Lymphoma
4.3.4Mantle Cell Lymphoma
5.2Risk Factors and Comorbidities
5.4.2Sources Not Used
5.4.3Forecast Assumptions and Methods
5.5Epidemiological Forecast for B-Cell NHL (2014–2024)
5.5.2Marginal Zone Lymphoma
5.5.3Diffuse Large B-Cell Lymphoma
5.5.4Mantle Cell Lymphoma
5.6.1Epidemiological Forecast Insight
5.6.2Limitations of the Analysis
5.6.3Strengths of the Analysis
6Current Treatment Options
6.2Product Profiles – Major Brands
6.2.6Zevalin (ibritumomab tiuxetan)
6.2.7Zydelig (idelalisib, GS-1101, CAL-101)
7Unmet Needs Assessment and Opportunity Analysis
7.2Unmet Needs Analysis
7.2.1Unmet Need: Therapies That Prolong OS or PFS and Delay Relapse in Indolent NHL Patients
7.2.2Unmet Need: Safe and More Tolerable Front-Line Agents for Indolent NHL Patients
7.2.3Unmet Need: Prolonged Survival Rates for MCL Patients
7.2.4Unmet Need: Improved Cure Rate and Survival for DLBCL Patients after Front-Line Therapy
7.2.5Unmet Need: Predictive and Prognostic Molecular Biomarkers
7.3.1Opportunity: More Cost-Effective Therapies
7.3.2Opportunity: Improved Consolidation/Maintenance Therapies for Follicular NHL Patients
7.3.3Opportunity: Novel Agents for Front-Line DLBCL and MCL Therapy
7.3.4Opportunity: Development of Novel Therapies for NHL Patients
8Research and Development Strategies
8.1.1Targeting Multiple NHL Subtypes and Lines of Therapy to Capture the Greatest Patient Share
8.1.2Inhibiting New Targets in Relapsed/Refractory NHL Patients
8.1.3Novel Approaches to NHL Treatment
8.1.4Developing Novel Drugs in Combination with Rituxan to Replace Chemoimmunotherapy Regimens
8.1.5Developing Second-Generation Therapies to Replace the Established Standards of Care at the End of Patent Life
8.1.6Companies Collaborating on Investigator-Sponsored, Early-Stage Trials to Minimize Up-Front Risk
8.1.7Introducing New Routes of Drug Delivery to Improve Patient Convenience
8.2Clinical Trial Design
8.2.1Indolent and Aggressive B-Cell NHL
9.2Promising Drugs in Clinical Development
9.2.3Copanlisib (BAY 80-6946)
9.3Innovative Early-Stage Approaches
9.3.1Adcetris (brentuximab vedotin)
9.3.7Chimeric Antigen Receptor T-Cell Therapies
10Pipeline Valuation Analysis
10.1Clinical Benchmarking of Key Pipeline Drugs
10.2Commercial Benchmarking of Key Pipeline Drugs
10.4Top-Line, 10-Year Forecast
11.4.1NHL Patient Population Segmentation
11.4.2Percentage of Drug-Treated Patients
11.4.3Drugs Included in Each Therapeutic Class
11.4.4Launch and Patent Expiry Dates
11.4.5General Pricing Assumptions
11.4.6Individual Drug Assumptions
11.4.7Generic and Biosimilar Erosion
11.5.1Physicians and Specialists Included in This Study
11.5.2Online Survey of High Prescribing Physicians
11.6About the Authors
11.6.3Therapy Area Director
11.6.4Global Director of Therapy Analysis and Epidemiology
11.6.5Global Head of Healthcare
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