OpportunityAnalyzer: Bladder Cancer – Opportunity Analysis and Forecasts to 2025

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The bladder cancer market in the seven major pharmaceutical markets (US, France, Germany, Italy, Spain, UK, and Japan) has remained largely unchanged in the past 10-20 years. However, significant expansion is expected starting in 2016, with the introduction of several new therapies that are projected to fuel market growth. In addition, bladder cancer has a robust early-stage pipeline that will contribute to market growth during the forecast period. Currently, the bladder cancer market is dominated by generic chemotherapy and immunotherapy. Though initially effective, toxicity and lack of clinical efficacy in improving overall survival have left the door open for more tolerable and effective drugs to be developed. In the past, bladder cancer has not been an area of focus for pharmaceutical companies, but that is rapidly changing as more companies focus on the bladder cancer market, recognizing the high level of unmet need and relatively clear regulatory path. During the forecast period, the market landscape will begin to change dramatically with the introduction of newer immunotherapies, specifically, PD-1 checkpoint modulators, of which five are expected to launch by 2025. These drugs will provide much-needed alternatives to bladder cancer patients who have not benefitted from traditional treatments.
Key Questions Answered
How will the bladder cancer market landscape in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan) change from 2015–2025?
What are the most promising late-stage pipeline drugs in bladder cancer?
How do the clinical and commercial attributes of late-stage pipeline therapies compare with one another, and against existing treatment options?
What are the unmet needs in bladder cancer treatment management?
What drivers and barriers will affect bladder cancer therapeutics sales in the 7MM over the forecast period?

Scope

Overview of bladder cancer, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and current management strategies.

Topline Bladder cancer market revenue from 2015–2025. Annual cost of therapy (ACOT) and major pipeline product sales in this forecast period are included.

Key topics covered include current treatment options, unmet needs and opportunities, and the drivers and barriers affecting bladder cancer therapeutics sales in the 7MM.

Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, synopses of innovative early-stage projects, and detailed analysis of late-stage pipeline products.

Analysis of the current and future market competition in the global bladder cancer therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

Reasons to Buy

The report will enable you to:

Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline.

Develop business strategies by understanding the trends shaping and driving the global bladder cancer therapeutics market.

Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the bladder cancer therapeutics market in the future.

Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.

Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.

Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments, and strategic partnerships.

Altor Bioscience
AstraZeneca
BioCancell
Bristol-Myers Squibb
Chugai
Cold Genesys
Eleven Biotherapeutics
Eli Lilly & Co.
Endo Pharmaceuticals
Exelixis
FKD Therapies Oy
Immunomedics
MedImmune
Merck & Co.
Merck KgAa
OncoGenex
Ono Pharmaceutical
Pfizer
Pierre Fabre Medicament
Roche

Table of Contents

Table of Contents

1 Table of Contents

1.1 List of Tables

1.2 List of Figures

2 Bladder Cancer: Executive Summary

2.1 Bladder Cancer Market in the 7MM Expected To Triple in Size From 2015 to 2025

2.2 Big Pharma Focuses on Label Expansion, While Smaller Companies Focus on Developing Drugs with Novel Mechanisms of Action

2.3 The Levels of Unmet Need Remain High Across Bladder Cancer Settings

2.4 Pipeline Agents Will Reduce Unmet Need, but Opportunities Remain

2.5 NMIBC Settings Are Not Expected to Change Significantly, While PD-1 Checkpoint Inhibitors Are Expected to Gain Stronghold in Advanced Disease Settings

2.6 What Do Physicians Think?

3 Disease Overview

3.1 Etiology and Pathophysiology

3.1.1 Etiology

3.1.2 Pathophysiology

3.2 Classification or Staging Systems

3.3 Symptoms

3.4 Prognosis

3.5 Quality of Life

4 Epidemiology

4.1 Disease Background

4.2 Risk Factors and Comorbidities

4.3 Global Trends

4.3.1 Incidence

4.3.2 Relative Survival

4.4 Forecast Methodology

4.4.1 Sources Used Tables

4.4.2 Forecast Assumptions and Methods

4.4.3 Sources Not Used

4.5 Epidemiological Forecast for Bladder Cancer (2015–2025)

4.5.1 Diagnosed Incident Cases of Bladder Cancer

4.5.2 Age-Specific Diagnosed Incident Cases of Bladder Cancer

4.5.3 Sex-Specific Diagnosed Incident Cases of Bladder Cancer

4.5.4 Age-Standardized Diagnosed Incidence Rates of Bladder Cancer

4.5.5 Diagnosed Incident Cases of Bladder Cancer by Stage at Diagnosis

4.5.6 Five-Year Diagnosed Prevalent Cases of Bladder Cancer

4.6 Discussion

4.6.1 Epidemiological Forecast Insight

4.6.2 Limitations of the Analysis

4.6.3 Strengths of the Analysis

5 Current Treatment Options

5.1 Overview

5.2 Diagnosis and Treatment

5.2.1 Diagnosis

5.2.2 Treatment Guidelines and Leading Prescribed Drugs

5.3 Clinical Practice

5.4 Product Profiles – Major Brands, Immunotherapies

5.4.1 Bacillus Calmette-Guérin (BCG)

5.4.2 Tecentriq (atezolizumab)

5.4.3 Opdivo (nivolumab)

5.5 Product Profiles – Major Brands, Chemotherapies

5.5.1 GemCis (gemcitabine/cisplatin)

5.5.2 Mitomycin C

5.5.3 Valstar (valrubicin)

5.5.4 Javlor (vinflunine ditartrate)

6 Unmet Needs Assessment and Opportunity Analysis

6.1 Overview

6.2 Improved Treatments for Patients with BCG-Relapsed/Refractory NMIBC

6.2.1 Unmet Need

6.2.2 Gap Analysis

6.2.3 Opportunity

6.3 Prevention of Disease Progression in Patients with NMIBC

6.3.1 Unmet Need

6.3.2 Gap Analysis

6.3.3 Opportunity

6.4 Therapies for Advanced Disease Beyond Immune Checkpoint Inhibitors

6.4.1 Unmet Need

6.4.2 Gap Analysis

6.4.3 Opportunity

6.5 Predictive Biomarkers to Drive Drug Discovery

6.5.1 Unmet Need

6.5.2 Gap Analysis

6.5.3 Opportunity

6.6 Improved Diagnostic Methods

6.6.1 Unmet Need

6.6.2 Gap Analysis

6.6.3 Opportunity

7 Research and Development Strategies

7.1 Overview

7.1.1 Drug Development by Small Pharmaceutical Companies

7.1.2 Intravesical Approaches for NMIBC May Give Way to Systemic Approaches in the Future

7.1.3 Identification of Prognostic Markers for PD-1 Checkpoint Inhibitors

7.1.4 Conversion of PD-1 Checkpoint Inhibitor Nonresponders to Responders

7.2 Clinical Trial Design

7.2.1 Registrational Studies: Open-Label, Non-Comparative Trial Designs Still Prevalent

7.2.2 Variability of Trial Endpoints in Both the NMIBC and Advanced Disease Settings

8 Pipeline Assessment

8.1 Overview

8.2 Promising Drugs in Clinical Development

8.2.1 CG-0070

8.2.2 Instiladrin (rAD-Interferon (IFN)/Syn3)

8.2.3 Vicinium (oportuzumab monatox)

8.2.4 Apatorsen

8.2.5 Cyramza (ramucirumab)

8.2.6 PD-1 Immune Checkpoint Inhibitors

8.3 Innovative Early-Stage Approaches

8.3.1 ALT-803

8.3.2 Cometriq (cabozantinib)

8.3.3 BC-819

8.3.4 IMMU-132 (sacituzumab govitecan)

9 Pipeline Valuation Analysis

9.1 Clinical Benchmark of Key Pipeline Drugs

9.2 Commercial Benchmark of Key Pipeline Drugs

9.3 Competitive Assessment

9.4 Top-Line 10-Year Forecast

9.4.1 US

9.4.2 5EU

9.4.3 Japan

10 Appendix

10.1 Bibliography

10.2 Abbreviations

10.3 Methodology

10.4 Forecasting Methodology

10.4.1 Diagnosed Bladder Cancer Patients

10.4.2 Percent Drug-Treated Patients

10.4.3 Drugs Included in Each Therapeutic Class

10.4.4 Launch and Patent Expiry Dates

10.4.5 General Pricing Assumptions

10.4.6 Individual Drug Assumptions

10.4.7 Generic Erosion

10.4.8 Pricing of Pipeline Agents

10.5 Primary Research – KOLs Interviewed for this Report

10.5.1 KOLs

10.6 Primary Research – Prescriber Survey

10.7 About the Authors

10.7.1 Analyst

10.7.2 Therapy Area Director

10.7.3 Epidemiologist

10.7.4 Managing Epidemiologist

10.7.5 Global Director of Therapy Analysis and Epidemiology

10.7.6 Global Head and EVP of Healthcare Operations and Strategy

10.8 About GlobalData

10.9 Contact Us

10.10 Disclaimer

Frequently asked questions

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