OpportunityAnalyzer: Small Cell Lung Cancer (SCLC) – Opportunity Analysis and Forecasts to 2024
All the vital news, analysis, and commentary curated by our industry experts.
Initially considered a curable disease due to substantial sensitivity to first-line chemotherapies, small cell lung cancer (SCLC) remains a fatal disease with poor outcomes due to high relapse rates, with the majority of patients surviving one year or less after diagnosis. Unlike non-small cell lung cancer (NSCLC), in which major advances in treatment have been made following the approval of several targeted therapies, the field of SCLC has seen little advancement for several decades.
For the purposes of this report, GlobalData considers the Global SCLC market to include SCLC-specific drug sales in the 7MM (US, 5EU [France, Germany Italy, Spain, and the UK], and Japan). The current market across these countries is dominated by the sale of major generic chemotherapy regimens. GlobalData estimated that the Global SCLC market was valued at $198m in 2014. Following the expected approval of new agents over the forecast period, relapsed/refractory patients will have significantly improved therapeutic options leading to rapid uptake of these drugs. The increased use of branded therapies in treatment-naïve and advanced patients, such as Yervoy, Opdivo, roniciclib, and sacituzumab govitecan, will be the primary driver of the substantial growth in the SCLC market over the forecast period, which is expected to grow at a positive CAGR of almost 28% in the 7MM.
Overview of SCLC, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and current treatment options.
Topline SCLC drug market revenue from 2014–2024, annual cost of therapy (ACOT), and major product sales in six patient segments during the forecast period are included.
Key topics covered include strategic competitor assessment, market characterization, unmet needs, opportunities, R&D strategies, and clinical trial mapping for the SCLC market.
Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, synopses of innovative early-stage projects, and detailed analysis of late-stage pipeline products. An interactive clinical and commercial analyzer tool is available.
Analysis of the current and future market competition in the global SCLC market. Insightful review of the key industry drivers, restraints, and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
Based on interviews with key opinion leaders (KOLs), GlobalData has identified the major unmet needs in the SCLC marketplace. Will the leading pipeline agents fulfil these unmet needs during the forecast period (2014–2024)?
What research and development (R&D) strategies will companies leverage to compete in the future SCLC marketplace?
Which pipeline products are poised to make a major clinical and commercial impact?
What clinical and commercial factors are likely to influence SCLC drug uptake in the 7MM?
Bristol Myers Squibb
Table of Contents
1Table of Contents
1.1List of Tables
1.2List of Figures
2.3Upcoming Related Reports
3.1Etiology and Pathophysiology
3.6Quality of Life
4.2Risk Factors and Comorbidities
4.3.2Stage at Diagnosis
4.4.2Sources Not Used
4.4.3Forecast Assumptions and Methods
4.5Epidemiological Forecast for SCLC (2014–2024)
4.5.1Diagnosed Incident Cases of SCLC
4.5.2Age-Specific Incident Cases of SCLC
4.5.3Sex-Specific Incident Cases of SCLC
4.5.4Age-Standardized Incidence of SCLC
4.5.5Stage-Specific Incident Cases of SCLC
4.5.6Five-Year Diagnosed Prevalent Cases of SCLC
4.5.7Five-Year Diagnosed Prevalent Cases of SCLC Segmented by Stage
4.6.1Epidemiological Forecast Insight
4.6.2Limitations of the Analysis
4.6.3Strengths of the Analysis
5Current Treatment Options
5.3Subsequent Lines of Therapy
6Unmet Needs Assessment and Opportunity Analysis
6.2Unmet Needs Analysis
6.2.1Early Diagnosis of Disease
6.2.2Therapies That Improve Overall Survival
6.2.3More Effective and Tolerable Therapies for Relapsed/Refractory Disease
6.2.4Discovery of Predictive Biomarkers and Understanding of the Underlying Causes of Disease
6.2.5Smoking Cessation Programs
6.3.1Standardized Methods for Biomarker Testing
6.3.2Developing Therapies with an Improved Safety Profile
6.3.3Understanding the Mechanisms Underlying the Rapid Emergence of Drug and Radiation Resistance
6.3.4Targeting Pathways Unique to Cancer Stem Cells
7.1.1Deconstructing the SCLC Genome
7.1.2New Diagnostic Approaches
7.1.3Reformulation of Available Chemotherapeutic Agents
7.2Clinical Trial Design
7.2.1Evolution of Endpoints for Cancer Immunotherapy Trials
7.2.2Health-Related Quality of Life Endpoints in Oncology Clinical Trials
7.2.3Design of Current Phase II and III Trials in SCLC
8.2Promising Drugs in Clinical Development
8.2.5Roniciclib (BAY 1000394)
8.2.7Sacituzumab Govitecan (IMMU-132)
8.2.8Sutent (sunitinib malate)
8.3Innovative Early-Stage Approaches
8.3.1Rovalpituzumab Tesirine (SC16LD6.5)
9Pipeline Valuation Analysis
9.1Clinical Benchmark of Key Pipeline Drugs
9.2Commercial Benchmark of Key Pipeline Drugs
9.4Top-Line 10-Year Forecast
10.4.1Diagnosed SCLC Patients
10.4.2Percent Drug-Treated Patients
10.4.3Drugs Included in Each Therapeutic Class
10.4.4Launch and Patent Expiry Dates
10.4.5General Pricing Assumptions
10.4.6Average Body Weight and Surface Area Across 7MM
10.4.7Individual Drug Assumptions
10.5Physicians and Specialists Included in this Study
10.6About the Authors
10.6.3Global Director of Therapy Analysis and Epidemiology
10.6.4Global Head of Healthcare
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