PharmaPoint: HER2-Negative/HR+ and Triple Negative Breast Cancer – Global Drug Forecast and Market Analysis to 2025
All the vital news, analysis, and commentary curated by our industry experts.
Human epidermal growth factor receptor type 2 (HER2-) breast cancer is the second most common cancer in the world and the most common cancer in women worldwide. HER2-negative breast cancer can be subdivided into hormone receptor-positive (HER2-/HR+), and triple negative breast cancer (TNBC). The prognoses of HER2-/HR+ and TNBC differ dramatically, as patients with TNBC progress more rapidly towards metastatic disease and only respond to chemotherapy agents. A large number of pipeline agents are being developed in HER2-/HR+ and/or TNBC, and are likely to change the treatment paradigm for these patients.
This report highlights the significant unmet need for expansion in the HER2- breast cancer marker across the eight major markets; it also discusses the associated commercial opportunities for new market entrants to gain a foothold in the market. GlobalData anticipates the HER2- breast cancer market to almost double, from $5.43B to $10.58B, over the forecast period of 2015-2025. The key drivers will be the incorporation of CDK4/6 inhibitors into the first-line metastatic setting and the rise of new targeted therapies and immunotherapies.
Overview of HER2- breast cancer, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, treatment guidelines and disease management.
Annualized HER2- breast cancer therapeutics market revenue, average cost of therapy and treatment usage pattern data from 2015 and forecast for seven years to 2025.
Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the HER2- breast cancer therapeutics market.
Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of middle- to late-stage pipeline drugs.
Analysis of the current and future market competition in the global HER2- breast cancer therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
In HER2-/HR+ breast cancer, the recent launch of CDK4/6 inhibitors in the US market has changed the paradigm of treatment in metastatic setting in these patients. How will new late-stage drugs will be positioned in comparison to the CDK 4/6 inhibitor Ibrance (palbociclib)? Which of these drugs will have the highest peak sales at the highest CAGR, and why?
Chemotherapy agents used in breast cancer are mostly well-established generics used in combination or as monotherapy. How will the advent of new therapies change the drug treatment landscape for HER2-negative breast cancer?
Several new late-stage agents target specific patients population. How will these agents will compete against chemotherapies in terms of efficacy and market size?
Merck & Co
Table of Contents
1Table of Contents
1.1List of Tables
1.2List of Figures
2.3Upcoming Related Reports
3.1Etiology and Pathophysiology
3.1.3Basic Breast Anatomy
3.2Disease Classification/Staging Systems
3.5Quality of Life
4.2Risk Factors and Comorbidities
4.3.5Prevalence and Survival
4.4.1Sources Used Tables
4.4.2Forecast Assumptions and Methods
4.4.3Sources Not Used
4.5Epidemiological Forecast for Non-Invasive DCIS Breast Cancer (2015–2025)
4.5.1Diagnosed Incident Cases of Non-Invasive DCIS Breast Cancer
4.5.2Diagnosed Incident Cases of Non-Invasive DCIS Breast Cancer by HER2 Status
4.6Epidemiological Forecast for Invasive Breast Cancer (2015–2025)
4.6.1Diagnosed Incident Cases of Invasive Breast Cancer
4.6.2Age-Specific Diagnosed Incident Cases of Invasive Breast Cancer
4.6.3Age-Standardized Diagnosed Incidence of Invasive Breast Cancer
4.6.4Five-Year Diagnosed Prevalent Cases of Invasive Breast Cancer
4.6.5Diagnosed Incident Cases of Invasive Breast Cancer by Stage at Diagnosis
4.6.6Diagnosed Incident Cases of Invasive Breast Cancer by HER2 Status
4.6.7Diagnosed Incident Cases of HER2+ Invasive Breast Cancer by Stage at Diagnosis, Menopausal Status, and Site of Metastasis
4.6.8Diagnosed Incident Cases of HER2-/HR+ Breast Cancer by Stage at Diagnosis, Menopausal Status, and Type of Biomarker Expression
4.6.9Diagnosed Incident Cases of TN Breast Cancer by Stage at Diagnosis and BRCA Expression
4.7.1Epidemiological Forecast Insight
4.7.2Limitations of the Analysis
4.7.3Strengths of the Analysis
5.1Diagnosis and Treatment Overview
5.1.1Screening and Diagnosis
5.1.2Treatment Overview of Loco-Regional Breast Cancer
5.1.3Neoadjuvant and Adjuvant Treatment Regimen
5.1.4Treatment of Metastatic HR+ Disease
5.1.5Treatment of Metastatic TNBC
5.1.6Treatment Guidelines and Leading Prescribed Drugs
6.2Product Profiles (Branded Therapies)
6.2.5Halaven (eribulin mesylate)
6.2.8Doxil/Caelyx (pegylated liposomal doxorubicin)
6.3Product Profiles (Hormonal Agents)
7Unmet Needs and Opportunities
7.1.1Defined Treatment Plan for BRCA+ Patients and the Prevention of Prophylactic Surgeries
7.1.2Targeted Treatment Options for Triple Negative Breast Cancer Patients
7.1.3Treatment of Brain Metastasis
7.1.4For HR+ Patients, Reduced Resistance to Hormonal Agents
7.1.5Improved Convenience of Administration of Hormonal Agents
8.3Poly ADP-Ribose Polymerase Inhibitors
8.3.2Talazoparib (BMN 673)
8.4Phosphoinositide 3 Kinase Inhibitors
8.4.1Buparlisib (BKM- 120)
8.5PD-1/PD-L1 Checkpoint Inhibitors
8.6Histone Deacetylase Inhibitors
8.7Antibody Drug Conjugates
8.7.1Sacituzimab govitecan (IMMU-132)
8.7.2Glembatumumab vedotin (CDX-011)
8.9Promising Drugs in Early Stage Clinical Development
8.9.4IDO Checkpoint Inhibitors
9Current and Future Players
9.2Trends in Corporate Strategy
10.1.2Drivers and Barriers – Global Issues
10.2.3Drivers and Barriers
10.3.3Drivers and Barriers
10.4.3Drivers and Barriers
10.5.3Drivers and Barriers
11.4.1Diagnosed Patients with HER2- Breast Cancer
11.4.2Percent Drug-Treated Patients
11.4.3Drugs Included in Each Therapeutic Class
11.4.4Launch and Patent Expiration Dates
11.4.5General Pricing Assumptions
11.4.6Average Body Weight and Surface Area Across the 8MM
11.4.7General Forecast Assumptions
11.4.8Individual Drug Assumptions
11.4.11Pricing of Pipeline Agents
11.5Primary Research – Key Opinion Leaderss Interviewed for This Report
11.6Primary Research – High-Prescribers Surveyed for this Report
11.7About the Authors
11.7.5Global Director of Therapy Analysis and Epidemiology
Frequently asked questions
Tel +44 20 7947 2745
Every customer’s requirement is unique. With over 220,000 construction projects tracked, we can create a tailored dataset for you based on the types of projects you are looking for. Please get in touch with your specific requirements and we can send you a quote.
Business Intelligence & Marketing Manager, SAL Heavy Lift
“The GlobalData platform is our go-to tool for intelligence services. GlobalData provides an easy way to access comprehensive intelligence data around multiple sectors, which essentially makes it a one-for-all intelligence platform, for tendering and approaching customers.
GlobalData is very customer orientated, with a high degree of personalised services, which benefits everyday use. The highly detailed project intelligence and forecast reports can be utilised across multiple departments and workflow scopes, from operational to strategic level, and often support strategic decisions. GlobalData Analytics and visualisation solutions has contributed positively when preparing management presentations and strategic papers.”
Market Analyst & Management, Liebherr-Werk
“COVID-19 has caused significant interference to our business and the COVID-19 intelligence from GlobalData has helped us reach better decisions around strategy. These two highlights have helped enormously to understand the projections into the future concerning our business units, we also utilise the project database to source new projects for Liebherr-Werk to use as an additional source to pitch for new business.”
Head of Key Accounts, Saab AB
Your daily news has saved me a lot of time and keeps me up-to-date with what is happening in the market, I like that you almost always have a link to the source origin. We also use your market data in our Strategic Business Process to support our business decisions. By having everything in one place on the Intelligence Center it has saved me a lot of time versus looking on different sources, the alert function also helps with this.
Marketing Intelligence Manager, Portugal Foods
Having used several other market research companies, I find that GlobalData manages to provide that ‘difficult-to-get’ market data that others can’t, as well as very diverse and complete consumer surveys.
Head of Customer Insight and Research, Standard Chartered
Our experience with GlobalData has been very good, from the platform itself to the people. I find that the analysts and the account team have a high level of customer focus and responsiveness and therefore I can always rely on. The platform is more holistic than other providers. It is convenient and almost like a one stop shop. The pricing suite is highly competitive and value for our organisation.
I like reports that inform new segments such as the analysis on generation Z, millennials, the impact of COVID 19 to our banking customers and their new channel habits. Secondly the specialist insight on affluent sector significantly increases our understanding about this group of customers. The combination of those give us depth and breadth of the evolving market.
I’m in the business of answering and helping people make decisions so with the intelligence center I can do that, effectively and efficiently. I can share quickly key insights that answer and satisfy our country stakeholders by giving them many quality studies and primary research about competitive landscape beyond the outlook of our bank. It helps me be seen as an advisory partner and that makes a big difference. A big benefit of our subscription is that no one holds the whole data and because it allows so many people, so many different parts of our organisation have access, it enables all teams to have the same level of knowledge and decision support.
Head of Consumer Sensory Insights, Givaudan
“I know that I can always rely on Globaldata’s work when I’m searching for the right consumer and market insights. I use Globaldata insights to understand the changing market & consumer landscape and help create better taste & wellbeing solutions for our customers in food, beverage and healthcare industries.
Globaldata has the right data and the reports are of very high quality compared to your competitors. Globaldata not only has overall market sizes & consumer insights on food & beverages but also provides insights at the ingredient & flavour level. That is key for B2B companies like Givaudan. This way we understand our customers’ business and also gain insight to our unique industry”
Senior Account Manager, TSYS
GlobalData provides a great range of information and reports on various sectors that is highly relevant, timely, easy to access and utilise. The reports and data dashboards help engagement with clients; they provide valuable industry and market insights that can enrich client conversations and can help in the shaping of value propositions. Moreover, using GlobalData products has helped increase my knowledge of the finance sector, the players within it, and the general threats and opportunities.
I find the consumer surveys that are carried out to be extremely beneficial and not something I have seen anywhere else. They provided an insightful view of why and which consumers take (or don’t) particular financial products. This can help shape conversations with clients to ensure they make the right strategic decisions for their business.
One of the challenges I have found is that data in the payments space is often piecemeal. With GD all of the data I need is in one place, but it also comes with additional market reports that provide useful extra context and information. Having the ability to set-up alerts on relevant movements in the industry, be it competitors or customers, and have them emailed directly to me, ensures I get early sight of industry activity and don’t have to search for news.