Net Present Value Model: Vitrakvi
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Overview
Evaluating the value of drugs is a complicated practice and requires a deep knowledge of the drug itself, the market currently and in the future, knowledge of cash inflows and outflows and the potential success rates for each stage of drug development. GlobalData has done all of this work for you, leveraging its gold standard Drugs Intelligence database to create high-value NPV models for purchase on a drug-by-drug basis.
Drug Operating Profit Model
Vitrakvi Drug Details
Larotrectinib Sulfate (Vitrakvi) is a anti-neoplastic agent. It is formulated as solution and hard gelatin capsules for oral route of administration. Vitrakvi is indicated for the treatment of adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation are metastatic or where surgical resection is likely to result in severe morbidity, have no satisfactory alternative treatments or that have progressed following treatment, neurotrophic receptor tyrosine kinase (NTRK) fusion gene positive advanced or recurrent.Larotrectinib (LOXO-101) is under development for the treatment of solid tumors such as pancreatic cancer, colon cancer, non-small cell lung cancer, soft tissue sarcoma, thyroid cancer, colorectal cancer, salivary gland cancer, biliary tumor, melanoma, bile duct cancer (Cholangiocarcinoma), secretory breast cancer, non-Hodgkin lymphomas, Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), histiocytic sarcoma, multiple myeloma, intrinsic brain stem tumors, optic pathway gliomas, pineal tumors, head and neck cancer squamous cell carcinoma, fibrosarcoma, gastrointestinal stromal tumor (GIST) including appendiceal cancer, pontine glioma, pancreatic cancer, ovarian cancer, kidney cancer, astrocytoma,neuroblastoma and cancers with a NTRK1, NTRK2, or NTRK3 gene fusion. It is administered orally. It targets pan tropomyosin receptor kinases (TrkA, TrkB, and TrkC). The drug candidate is developed based on Array drug discovery platform.
Report Coverage
GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
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Reasons to Buy
- Better understand the quantitative value of a specific drug
- Create or support internal NPV models to improve accuracy
- Understand the profit a drug is expected to make, taking into account revenue and cost forecasts leveraging public and proprietary data sets.
Frequently asked questions
- All drug sales and forecasts within NPV Model are calculated in our proprietary company based models . In these models, Analyst Consensus forecasts are built by using company-specific broker reports to create the sales forecasts for each Drug and Segment.
- Sales and forecasts are not indication-specific where drugs are approved , or in development, for multiple indications. Please refer to GlobalData’s Disease Analysis reports for indication-specific sales forecasts.
- Risk-adjusted NPVs use GlobalData’s LoA and PTSR for the indication in the highest development stage. Please refer to the Likelihood of Approval methodology for more details on this content.
GlobalData’s NPV Model is a premium model providing a fully-interactive forecasting and valuation tool, driven by Analyst Consensus estimates, enabling users to analyze and customize valuations for pharmaceutical assets including drugs or segments. The tool provides 17-year drug forecasts from companies with sales forecast data in the pharmaceutical industry, including established global firms and emerging biotechs, which allows access to critical information to facilitate strategic decision making around pharmaceutical assets
The NPV Model includes a forecasted Revenue Model, followed by a proprietary Patent Expiry Model, Operating Profit Model, Net Profit (apply Tax rate) and Discounted Cash Flow (apply Discount rates), to derive Net Present Value (NPV) for a chosen pharmaceutical asset
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