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Number of ongoing Clinical Trials (for drugs) involving Alagille Syndrome by Phase

  • There are currently 4 ongoing clinical trials involving Alagille Syndrome

  • Of the 4 trials,3 trials are in Phase II

  • Furthermore, 1 trials are in Phase III

Number of ongoing Clinical Trials (for drugs) involving Alagille Syndrome by Phase

Published: October 2021
Source: GlobalData

The global pharmaceutical industry is steadily developing new drugs for Alagille Syndrome, a genetic disorder. North America and Europe are among some of the prominent regions involved in Alagille Syndrome-related drug trials. 

Alagille Syndrome related clinical trials sponsors 

Mirum Pharmaceuticals Inc, and Albireo Pharma Inc are a few notable sponsors for clinical trials involving Alagille Syndrome. A clinical trial sponsor can be a Company, Government, Individual, or Institution. 

Marketed Drug involving Alagille Syndrome  

Maralixibat chloride (Livmarli) is a key marketed drug involving Alagille Syndrome. 

Maralixibat chloride (Livmarli) is an anti-pruritus agent. It functions via Ileal Sodium/Bile Acid Cotransporter (Apical Sodium Dependent Bile Acid Transporter or ASBT or Sodium/Taurocholate Cotransporting Polypeptide Ileal or Solute Carrier Family 10 Member 2 or SLC10A2) Inhibitor mechanism of action.  It is formulated as solution for oral route of administration. Livmarli is indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome (ALGS) 1 year of age and older. Livmarli received first approval in 2021 and is marketed in the US by Mirum Pharmaceuticals Inc

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