The Global Drug sales of Nexium stood at USD 1,285 Millions in 2022
The indicator recorded a historical decline (CAGR) of17% between 2019 to 2022 and is expected to decline by ...
GlobalData projects the indicator to decline at a CAGR of...
Esomeprazole magnesium (Nexium) is a sulfinyl benzimidazole derivative, acts as anti-ulcer agent. It is formulated as granules, hard gelatin capsules with coated pellets, capsules, tablets as delayed release formulation for oral route of administration.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide and it forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen.
Nexium Overview
Nexium is marketed for the treatment of several indications in Gastrointestinal therapy area.
Nexium is indicated for the treatment of acid-related diseases, reflux esophagitis (gastroesophageal reflux disease), hypersecretory conditions, gastric ulcers, zollinger-Ellison syndrome (gastrinoma), helicobacter pylori infections, duodenal ulcers, esophagitis, nonerosive reflux disease (NERD), and gastritis and peptic ulcers.
Nexium was first approved in 2000 and is sold globally including the US, the UK, France, Germany, and Japan by several pharma giants including AstraZeneca Plc, and Daiichi Sankyo Co Ltd. Nexium drug sales include the historical sales that are derived from company financial reports, and consensus forecasts are calculated based on company-specific broker reports as well as GlobalData’s proprietary methodology.
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