The Global Drug sales of Xarelto stood at USD 2,473 Millions in 2022
The indicator recorded a historical growth (CAGR) of2.25% between 2019 to 2022 and is expected to decline by ...
GlobalData projects the indicator to decline at a CAGR of...
Rivaroxaban (Xarelto) belongs to the class of antithrombotic agents. It is formulated as film-coated tablets, tablets, granules/powder for suspension and suspension for oral route of administration.
Mechanism of Action
Rivaroxaban is a factor Xa inhibitor. The drug candidate blocks factor Xa, an enzyme that is involved in the production of thrombin. Thrombin is central to the process of blood clotting. The activated Factor X (Factor Xa) is a central component of the prothrombinase complex, which converts large amounts of prothrombin (Factor II) to thrombin, described as the “thrombin burst”. By blocking factor Xa, the levels of thrombin decrease, which reduces the risk of blood clots forming in the veins and arteries, and also treats existing clots.
Xarelto Overview
Xarelto is marketed for the treatment of several indications in Cardiovascular, and Hematological Disorders therapy areas.
Xarelto is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation is indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients undergoing knee or hip replacement surgery. Rivaroxaban is indicated for the treatment of adults, to prevent venous thromboembolism (VTE, the formation of clots in the veins) in patients who are undergoing surgery to replace a hip or knee; to prevent stroke caused by a blood clot in the brain and systemic embolism (a blood clot in a blood vessel) in patients with non-valvular atrial fibrillation (irregular rapid contractions of the upper chambers of the heart); and to treat deep vein thrombosis (DVT, a blood clot in a deep vein, usually in the leg), and to prevent DVT re-occurring and pulmonary embolism (a clot in a blood vessel supplying the lungs) following a severe case of DVT. Xarelto is also indicated for the treatment of pulmonary thromboembolism and deep vein thrombosis. Xarelto film-coated tablet (2.5 mg), in combination with 75 mg -100 mg acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in patients with symptomatic peripheral artery disease (PAD) at demonstrated high risk of major adverse limb events (MALE) or major adverse cardiovascular and cerebrovascular events (MACCE). Xarelto is indicated for thromboprophylaxis in pediatric patients aged 2 years and older with congenital heart disease who have undergone the Fontan procedure, venous thromboembolism (VTE) and the reduction in the risk of recurrent VTE in pediatric patients from birth to less than 18 years after at least 5 days of initial parenteral anticoagulant treatment.
Xarelto was first approved in 2008 and is sold globally including the US, the UK, Australia, Germany, and Japan by several pharma giants including Bayer AG, and Johnson & Johnson. Xarelto drug sales recorded a high-single digit Year on Year growth in 2022. Xarelto drug sales include the historical sales that are derived from company financial reports, and consensus forecasts are calculated based on company-specific broker reports as well as GlobalData’s proprietary methodology.
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