Knee Reconstruction Pipeline by Development Stages, Segments, Region and Countries, Regulatory Path and Key Companies

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Published: June 13, 2024 Report Code: GDME1768EPD-ST

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Knee Reconstruction Pipeline Market Report Overview

Knee reconstruction is a surgical procedure involving the replacement of damaged or diseased parts of the knee joint. The knee reconstruction procedures include devices (implants) used in primary, partial, and revision knee replacement. A knee replacement is a common type of surgery where a damaged knee joint is replaced with an artificial one or an implant. The report also includes information about the territories wherein the clinical trials are in progress, the regulatory paths followed by the trials, and the companies associated with the trials.

Key Segment ·       Primary Knee Replacement

·       Revision Knee Replacement

·       Partial Knee Replacement

·       Primary Cementless Knee Replacement

·       Unicompartmental Partial Knee Replacement
Key Territory ·       The US

·       China

·       Europe

·       Australia

·       New Zealand
Key Regulatory Paths ·       510(k)

·       NMPA

·       CE

·       PMA

·       TGA
Leading Companies ·       4WEB Medical Inc

·       Active Implants LLC

·       Artimplant AB (Inactive)

·       Aspect Biosystems Ltd

·       B. Braun Melsungen AG
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Knee Reconstruction Pipeline Market Segmentation by Segments

The key segments in the knee reconstruction pipeline market are primary knee replacement, revision knee replacement, partial knee replacement, primary cementless knee replacement, and unicompartmental partial knee replacement among others.

Knee Reconstruction Pipeline Market Analysis by Segments, 2024 (%)

Knee Reconstruction Pipeline Market Analysis by Segments, 2024 (%)

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Knee Reconstruction Pipeline Market Segmentation by Territories

A few of the key territories with the knee reconstruction pipeline market are the US, China, Europe, Australia, and New Zealand among others. As of June 2024, the US accounts for the highest number of knee reconstruction pipeline products.

Knee Reconstruction Pipeline Market Analysis by Territories, 2024 (%)

Knee Reconstruction Pipeline Market Analysis by Territories, 2024 (%)

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Knee Reconstruction Pipeline Market Segmentation by Regulatory Paths

A few of the key regulatory paths in the knee reconstruction pipeline products market are 510(k), NMPA, CE, PMA, and TGA among others. As of June 2024, 510(k) accounts for the most followed pathway for pipeline products in the knee reconstruction market.

Knee Reconstruction Pipeline Market Analysis by Regulatory Paths, 2024 (%)

Knee Reconstruction Pipeline Market Analysis by Regulatory Paths, 2024 (%)

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Knee Reconstruction Pipeline Market – Competitive Landscape

A few of the key companies associated with the knee reconstruction pipeline market are 4WEB Medical Inc, Active Implants LLC, Artimplant AB (Inactive), Aspect Biosystems Ltd, and B. Braun Melsungen AG among others.

4WEB Medical Inc  : 4WEB Medical Inc (4WEB) is an orthopedic implant device company that designs 3D printed titanium implants. The company also designs and develops implants for trauma, tumor, and patient-specific applications. Its product portfolio includes anterior, posterior, cervical, and lateral spine truss systems. It utilizes 3D printing technology to develop 4WEB Medical’s proprietary truss implant platform. 4WEB is headquartered in Frisco, Texas, the US.

Active Implants LLC: Active Implants LLC (Active Implants), formerly Active Implants Corp, is a medical equipment provider that develops orthopedic equipment. The company develops and commercializes polymer orthopedic implant solutions which include tribofit hip systems, tribofit instrumentation equipment, NuSurface meniscus implants, and others. It develops and markets low wear and bone-spurting orthopedic implant solutions that are made of polyurethane materials. Active Implants’ joint replacement products are manufactured using poly-carbonate urethane materials. The company operates in the Netherlands, Israel, and others. Active Implants is headquartered in Memphis, Tennessee, the US.

Knee Reconstruction Pipeline Market Analysis by Companies, 2024

Knee Reconstruction Pipeline Market Analysis by Companies, 2024Buy the Full Report for More Company Insights into the Knee Reconstruction Pipeline Market
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Segments Covered in the Report

Knee Reconstruction Pipeline Market Segments Outlook (2024)

  • Primary Knee Replacement
  • Revision Knee Replacement
  • Partial Knee Replacement
  • Primary Cementless Knee Replacement
  • Unicompartmental Partial Knee Replacement

Knee Reconstruction Pipeline Market Territories Outlook (2024)

  • The US
  • China
  • Europe
  • Australia
  • New Zealand

Knee Reconstruction Pipeline Market Regulatory Paths Outlook (2024)

  • 4WEB Medical Inc
  • Active Implants LLC
  • Artimplant AB (Inactive)
  • Aspect Biosystems Ltd
  • Braun Melsungen AG

Scope

This report provides:

  • Extensive coverage of the knee reconstruction under development.

  • An exhaustive list of major pipeline products and their details, including product description, licensing and collaboration details, and other developmental activities.

  • Reviews of major players involved in the development of knee reconstruction and lists all their pipeline projects.

  • Coverage of pipeline products based on various stages of development ranging from early development to approved/issued stage.

  • Key clinical trial data of ongoing clinical trials specific to pipeline products.

  • Recent developments in the segment/industry.

Reasons to Buy

  • Formulate significant competitor information, analysis, and insights to improve R&D strategies.

  • Identify emerging players with potentially strong product portfolios and create effective counter strategies to gain a competitive advantage.

  • Identify and understand important and diverse types of knee reconstruction under development.

  • Develop market-entry and market-expansion strategies.

  • Plan mergers and acquisitions effectively by identifying major players with the most promising pipeline.

  • Carry out an in-depth analysis of the product’s current stage of development, territory, and estimated launch date.

4WEB Medical Inc
Active Implants LLC
Artimplant AB (Inactive)
Aspect Biosystems Ltd
B. Braun Melsungen AG
Bactiguard Holding AB
Binghamton University
BioPoly LLC
Bonovo Orthopedics Inc
CEA-Leti
CeramTec GmbH
Clemson University
Columbia University Irving Medical Center
ConforMIS Inc
Corin Group Ltd
CytexOrtho
Delta Orthopedics LLC
DiFusion Technologies Inc
Ecole de technologie superieure
Elite Surgical Supplies (Pty) Ltd
Episurf Medical AB
Exactech Inc
EZ ORTHOPEDICS ISRAEL
ForCast Orthopedics Inc
Fuse Medical Inc
Ganymed Robotics SAS
Genovel Orthopedics Inc
Georgia Institute of Technology
Hospital for Special Surgery
Indian Institute of Technology Bombay
Invibio Knee Ltd
Kinamed Inc
Materialise NV
Materials Mines Paris Tech Center
Medacta Group SA
MicroPort Orthopedics Inc
MicroPort Scientific Corp
Nano Interface Technology LLC (Inactive)
NovoPedics, Inc.
Ohio State University
Okani Medical Technology
OrthoGrid Systems Inc
Orthonika Ltd
OrthoSensor Inc
Resultados y Calidad del Sistema Sanitario Publico de Andalucia
RIH Orthopaedic Foundation Inc
Sanatmetal Ltd.
Sensortech Corp
SINTX Technologies Inc
Smith & Nephew Plc
Stellenbosch University
Stevens Institute of Technology
Think Surgical, Inc.
University of Bath
University of Florida
University of South Carolina
Zimmer Biomet Holdings Inc
ZKR Orthopedics Inc

Table of Contents

|1 Table of Contents 3

|1.1 List of Tables 9

|1.2 List of Figures 15

2 Introduction 16

2.1 Knee Reconstruction Overview 16

3 Products under Development 17

3.1 Knee Reconstruction – Pipeline Products by Stage of Development 17

3.2 Knee Reconstruction – Pipeline Products by Segment 18

3.3 Knee Reconstruction – Pipeline Products by Territory 19

3.4 Knee Reconstruction – Pipeline Products by Regulatory Path 20

3.5 Knee Reconstruction – Pipeline Products by Estimated Approval Date 21

3.6 Knee Reconstruction – Ongoing Clinical Trials 22

4 Knee Reconstruction – Pipeline Products under Development by Companies 23

4.1 Knee Reconstruction Companies – Pipeline Products by Stage of Development 23

4.2 Knee Reconstruction – Pipeline Products by Stage of Development 26

5 Knee Reconstruction Companies and Product Overview 29

5.1 4WEB Medical Inc Company Overview 29

5.1.1 4WEB Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 29

5.2 Active Implants LLC Company Overview 30

5.2.1 Active Implants LLC Pipeline Products & Ongoing Clinical Trials Overview 30

5.3 Artimplant AB (Inactive) Company Overview 34

5.3.1 Artimplant AB (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 34

5.4 Aspect Biosystems Ltd Company Overview 35

5.4.1 Aspect Biosystems Ltd Pipeline Products & Ongoing Clinical Trials Overview 35

5.5 B. Braun Melsungen AG Company Overview 36

5.5.1 B. Braun Melsungen AG Pipeline Products & Ongoing Clinical Trials Overview 36

5.6 Bactiguard Holding AB Company Overview 37

5.6.1 Bactiguard Holding AB Pipeline Products & Ongoing Clinical Trials Overview 37

5.7 Binghamton University Company Overview 38

5.7.1 Binghamton University Pipeline Products & Ongoing Clinical Trials Overview 38

5.8 BioPoly LLC Company Overview 39

5.8.1 BioPoly LLC Pipeline Products & Ongoing Clinical Trials Overview 39

5.9 Bonovo Orthopedics Inc Company Overview 44

5.9.1 Bonovo Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 44

5.10 CEA-Leti Company Overview 45

5.10.1 CEA-Leti Pipeline Products & Ongoing Clinical Trials Overview 45

5.11 CeramTec GmbH Company Overview 46

5.11.1 CeramTec GmbH Pipeline Products & Ongoing Clinical Trials Overview 46

5.12 Clemson University Company Overview 47

5.12.1 Clemson University Pipeline Products & Ongoing Clinical Trials Overview 47

5.13 Columbia University Irving Medical Center Company Overview 48

5.13.1 Columbia University Irving Medical Center Pipeline Products & Ongoing Clinical Trials Overview 48

5.14 ConforMIS Inc Company Overview 49

5.14.1 ConforMIS Inc Pipeline Products & Ongoing Clinical Trials Overview 49

5.15 Corin Group Ltd Company Overview 53

5.15.1 Corin Group Ltd Pipeline Products & Ongoing Clinical Trials Overview 53

5.16 CytexOrtho Company Overview 55

5.16.1 CytexOrtho Pipeline Products & Ongoing Clinical Trials Overview 55

5.17 Delta Orthopedics LLC Company Overview 56

5.17.1 Delta Orthopedics LLC Pipeline Products & Ongoing Clinical Trials Overview 56

5.18 DiFusion Technologies Inc Company Overview 57

5.18.1 DiFusion Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 57

5.19 Ecole de technologie superieure Company Overview 58

5.19.1 Ecole de technologie superieure Pipeline Products & Ongoing Clinical Trials Overview 58

5.20 Elite Surgical Supplies (Pty) Ltd Company Overview 59

5.20.1 Elite Surgical Supplies (Pty) Ltd Pipeline Products & Ongoing Clinical Trials Overview 59

5.21 Episurf Medical AB Company Overview 60

5.21.1 Episurf Medical AB Pipeline Products & Ongoing Clinical Trials Overview 60

5.22 Exactech Inc Company Overview 69

5.22.1 Exactech Inc Pipeline Products & Ongoing Clinical Trials Overview 69

5.23 EZ ORTHOPEDICS ISRAEL Company Overview 74

5.23.1 EZ ORTHOPEDICS ISRAEL Pipeline Products & Ongoing Clinical Trials Overview 74

5.24 ForCast Orthopedics Inc Company Overview 75

5.24.1 ForCast Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 75

5.25 Fuse Medical Inc Company Overview 76

5.25.1 Fuse Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 76

5.26 Ganymed Robotics SAS Company Overview 77

5.26.1 Ganymed Robotics SAS Pipeline Products & Ongoing Clinical Trials Overview 77

5.27 Genovel Orthopedics Inc Company Overview 78

5.27.1 Genovel Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 78

5.28 Georgia Institute of Technology Company Overview 80

5.28.1 Georgia Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 80

5.29 Hospital for Special Surgery Company Overview 81

5.29.1 Hospital for Special Surgery Pipeline Products & Ongoing Clinical Trials Overview 81

5.30 Indian Institute of Technology Bombay Company Overview 83

5.30.1 Indian Institute of Technology Bombay Pipeline Products & Ongoing Clinical Trials Overview 83

5.31 Invibio Knee Ltd Company Overview 84

5.31.1 Invibio Knee Ltd Pipeline Products & Ongoing Clinical Trials Overview 84

5.32 Kinamed Inc Company Overview 87

5.32.1 Kinamed Inc Pipeline Products & Ongoing Clinical Trials Overview 87

5.33 Materialise NV Company Overview 88

5.33.1 Materialise NV Pipeline Products & Ongoing Clinical Trials Overview 88

5.34 Materials Mines Paris Tech Center Company Overview 89

5.34.1 Materials Mines Paris Tech Center Pipeline Products & Ongoing Clinical Trials Overview 89

5.35 Medacta Group SA Company Overview 90

5.35.1 Medacta Group SA Pipeline Products & Ongoing Clinical Trials Overview 90

5.36 MicroPort Orthopedics Inc Company Overview 91

5.36.1 MicroPort Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 91

5.37 MicroPort Scientific Corp Company Overview 96

5.37.1 MicroPort Scientific Corp Pipeline Products & Ongoing Clinical Trials Overview 96

5.38 Nano Interface Technology LLC (Inactive) Company Overview 99

5.38.1 Nano Interface Technology LLC (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 99

5.39 NovoPedics, Inc. Company Overview 100

5.39.1 NovoPedics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 100

5.40 Ohio State University Company Overview 101

5.40.1 Ohio State University Pipeline Products & Ongoing Clinical Trials Overview 101

5.41 Okani Medical Technology Company Overview 102

5.41.1 Okani Medical Technology Pipeline Products & Ongoing Clinical Trials Overview 102

5.42 OrthoGrid Systems Inc Company Overview 103

5.42.1 OrthoGrid Systems Inc Pipeline Products & Ongoing Clinical Trials Overview 103

5.43 Orthonika Ltd Company Overview 104

5.43.1 Orthonika Ltd Pipeline Products & Ongoing Clinical Trials Overview 104

5.44 OrthoSensor Inc Company Overview 105

5.44.1 OrthoSensor Inc Pipeline Products & Ongoing Clinical Trials Overview 105

5.45 Resultados y Calidad del Sistema Sanitario Publico de Andalucia Company Overview 106

5.45.1 Resultados y Calidad del Sistema Sanitario Publico de Andalucia Pipeline Products & Ongoing Clinical Trials Overview 106

5.46 RIH Orthopaedic Foundation Inc Company Overview 108

5.46.1 RIH Orthopaedic Foundation Inc Pipeline Products & Ongoing Clinical Trials Overview 108

5.47 Sanatmetal Ltd. Company Overview 109

5.47.1 Sanatmetal Ltd. Pipeline Products & Ongoing Clinical Trials Overview 109

5.48 Sensortech Corp Company Overview 110

5.48.1 Sensortech Corp Pipeline Products & Ongoing Clinical Trials Overview 110

5.49 SINTX Technologies Inc Company Overview 111

5.49.1 SINTX Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 111

5.50 Smith & Nephew Plc Company Overview 112

5.50.1 Smith & Nephew Plc Pipeline Products & Ongoing Clinical Trials Overview 112

5.51 Stellenbosch University Company Overview 114

5.51.1 Stellenbosch University Pipeline Products & Ongoing Clinical Trials Overview 114

5.52 Stevens Institute of Technology Company Overview 115

5.52.1 Stevens Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 115

5.53 Think Surgical, Inc. Company Overview 116

5.53.1 Think Surgical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 116

5.54 University of Bath Company Overview 118

5.54.1 University of Bath Pipeline Products & Ongoing Clinical Trials Overview 118

5.55 University of Florida Company Overview 119

5.55.1 University of Florida Pipeline Products & Ongoing Clinical Trials Overview 119

5.56 University of South Carolina Company Overview 120

5.56.1 University of South Carolina Pipeline Products & Ongoing Clinical Trials Overview 120

5.57 Zimmer Biomet Holdings Inc Company Overview 121

5.57.1 Zimmer Biomet Holdings Inc Pipeline Products & Ongoing Clinical Trials Overview 121

5.58 ZKR Orthopedics Inc Company Overview 122

5.58.1 ZKR Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 122

6 Knee Reconstruction- Recent Developments 125

6.1 Jun 04, 2024: Medtronic Announces Dr. Goran Petrovski to Join Diabetes Medical Affairs Team 125

6.2 Jun 04, 2024: HSS Honors Distinguished Physicians and Visionary Philanthropist Kenneth C. Griffin and Announces $12 Million Multi-Year Gift from Griffin to Advance Orthopedic Research and Care 125

6.3 Jun 04, 2024: Medtronic Announces Retirement of Rob Ten Hoedt as Executive Vice President and President, Global Regions, Effective as of June 28, 2024 126

6.4 May 23, 2024: Orthofix Names Max Reinhardt President of Global Spine Business 126

6.5 May 13, 2024: Exactech Enhances High Technology Knee System with New Balancing Software 127

6.6 May 08, 2024: Zimmer Receives 510(K) Clearance For Persona Personalized Knee System (Persona OsseoTi 3-Peg Patella) 127

6.7 May 08, 2024: Encore Medical Receives 510(K) Clearance For EMPOWR Revision Symmetric Knee Cone 127

6.8 May 08, 2024: Paragon 28 Reports First Quarter 2024 Financial Results and Reaffirms 2024 Net Revenue Guidance 128

6.9 May 02, 2024: Paragon 28 to Present at the Bank of America Securities 2024 Healthcare Conference 128

6.10 May 02, 2024: Zimmer Biomet Announces First Quarter 2024 Financial Results 128

6.11 Apr 30, 2024: Beijing Keyi Medical Device Technology Receives 510(K) Clearance For KeYi Total Knee System 130

6.12 Apr 25, 2024: Materialise Reports First Quarter 2024 Results 130

6.13 Apr 24, 2024: Episurf Medical Announces Interim Report 1 January – 31 March 2024 132

6.14 Apr 24, 2024: Medtronic Names Yarmela Pavlovic as Chief Regulatory Officer 133

6.15 Apr 23, 2024: Orthofix Schedules First Quarter 2024 Earnings Release and Conference Call for May 7, 2024 133

6.16 Apr 23, 2024: Symbios Origin Posterior Stabilised Patient-Matched Total Knee Replacement Device: Risk of Early Revision, Dsi/2024/005 133

6.17 Apr 22, 2024: Beijing Chunlizhengda Medical Instruments Receives FDA 510(k) Clearance for XN Knee Prosthesis System 135

6.18 Apr 18, 2024: Kyocera Medical Technologies Receives FDA 510(k) Clearance for TRIBRID Unicompartmental Knee System 135

6.19 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for EVOLUTION Hinge Knee System 136

6.20 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for DCW Modular Distal Femoral System 136

6.21 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for Evolution MP Total Knee System 136

6.22 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for REPIPHYSIS Limb Salvage System 136

6.23 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for Evolution MP Adaptive CS Insert 137

6.24 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for EVOLUTION MP Adaptive PS Tibial Insert 137

6.25 Apr 16, 2024: MicroPort Orthopedics Receives Additional FDA 510(k) Clearance for EVOLUTION MP CS/CR Porous Femur 137

6.26 Apr 16, 2024: Orthofix Names Andres Cedron as New Chief Legal Officer 137

6.27 Apr 04, 2024: Paragon 28 Announces CFO Transition, Provides Preliminary Unaudited Net Revenue for First Quarter 2024, and Reaffirms Net Revenue Guidance for Fiscal Year 2024 138

6.28 Apr 02, 2024: DePuy Synthes Receives 510(K) Clearance For LPS (Limb Preservation System) Lower Extremity Dovetail Intercalary 139

6.29 Apr 02, 2024: DePuy Synthes Receives Additional FDA 510(k) Clearance for Attune Knee System 139

6.30 Apr 02, 2024: DePuy Synthes Obtains Additional 510(K) Clearance For ATTUNE Cementless Knee System 140

6.31 Apr 02, 2024: DePuy Synthes Obtains Additional 510(K) Clearance For Sigma High Performance (HP) Partial Knee 140

6.32 Mar 26, 2024: ARPA-H Awards Columbia Researchers Nearly $39M to Develop a Living Knee Replacement 140

6.33 Mar 20, 2024: New Knee Research Finds Exactech Technologies Improve Patient Outcomes 142

6.34 Mar 18, 2024: World’s First Total Knee Replacement Patient Treated With Polarisar Breakthrough Mixed-Reality Surgical Guidance System 143

6.35 Mar 18, 2024: Lucas Vitale Joins Orthofix as Chief People and Business Operations Officer 144

6.36 Mar 13, 2024: Medacta Group Reports Robust Revenue Growth of

19.5% at Constant Currency and Adjusted EBITDA Margin

26.3%, or

27.9% at Constant Currency in FY 2023 144

6.37 Mar 12, 2024: Medtronic To Present At Barclays Global Healthcare Conference 147

6.38 Mar 07, 2024: Episurf Medical AB’s 2023 Annual Report is Available 147

6.39 Feb 21, 2024: Orthofix Schedules Fourth Quarter and Full Year 2023 Earnings Release and Conference Call for March 5, 2024 147

6.40 Feb 15, 2024: Bodycad Receives Additional 510(K) Clearance For FINE Osteotomy Around The Knee 147

6.41 Feb 14, 2024: ZKR Orthopedics Receives IDE Approval for Clinical Trial 147

6.42 Feb 14, 2024: THINK Surgical to Collaborate with b-ONE Ortho Corporation for Robotic TKA 148

6.43 Feb 14, 2024: AAOS24: POLARIS to Demonstrate its STELLAR Knee Surgical Guidance System 149

6.44 Feb 13, 2024: Stryker showcases commitment to innovation at AAOS 2024 Annual Meeting 149

6.45 Feb 12, 2024: Enovis to Highlight Latest Technologies Across the Orthopedic Care Continuum at 2024 AAOS Annual Meeting 150

6.46 Feb 12, 2024: Monogram Orthopaedics to Present Rescheduled Product Discussion with Surgeon Reaction during AAOS Annual Meeting 151

6.47 Feb 12, 2024: Medacta to Feature GMK SpheriKA and Innovative Personalized Solutions at AAOS 2024 151

6.48 Feb 12, 2024: Smith+Nephew to Attend AAOS 2024 Annual Meeting 152

6.49 Feb 12, 2024: Orthopaedic Experts Identify Best Practices for Wound Closure and Dressing Management in Total Knee and Total Hip Arthroplasty 152

6.50 Jan 31, 2024: Stryker Corp Reports Strong Q4 and Full Year 2023 Results; Forecasts Continued Growth 153

6.51 Jan 31, 2024: Japan Medical Dynamic Marketing Announces Consolidated Financial Results for the Third Quarter of the Fiscal Year Ending March 2024 153

6.52 Jan 29, 2024: Limacorporate Receives Additional 510(K) Clearance For AMF Revision TT Cones 154

6.53 Jan 29, 2024: MicroPort Orthopedics Receives FDA 510(k) Clearance for EVOLUTION Tibial Cone 154

6.54 Jan 25, 2024: PIH Health One of the First in LA to Offer Persona IQ, the World’s First and Only Smart Knee Implant for Total Knee Replacement Surgery 155

6.55 Jan 16, 2024: Results from up to 10 years follow-up of Episealer patients accepted for presentation at international orthopaedic congress 155

6.56 Jan 15, 2024: IMPLANET Reports 2023 Annual Revenue of €7.4 Million 155

6.57 Jan 09, 2024: Orthofix Medical Announces Preliminary 2023 Fourth Quarter and Full-Year Net Sales Results 157

6.58 Dec 31, 2023: DePuy Ireland Receives Additional 510(K) Clearance For ATTUNE Porous Fixed Bearing Tibial Base 157

6.59 Dec 12, 2023: Orthofix Announces Agreement with Engine Capital and Appointment of Three New Independent Directors to Further Advance Position as Leading Global Spine and Orthopedics Company 158

6.60 Nov 29, 2023: Zimmer Receives Additional 510(K) Clearance For ROSA Partial Knee System 158

6.61 Nov 28, 2023: Monogram Orthopaedics Delivers First Surgical Robot 159

6.62 Nov 27, 2023: Stronger Thigh Muscles May Prevent Knee Replacement Surgery 159

6.63 Nov 15, 2023: MicroPort Orthopedics Receives 510(K) Clearance For EVOLUTION Cement Keel 160

6.64 Nov 15, 2023: Amplitude Receives 510(K) Clearance For TRAX CR Total Knee System 160

6.65 Nov 15, 2023: PolarisAR Receives 510(K) Clearance For STELLAR Knee 160

6.66 Nov 08, 2023: Orthofix Reports Third Quarter 2023 Results 161

6.67 Nov 07, 2023: Completion of First in Human Clinical Trial Two-Year Follow-up for the LIFT Implant 162

6.68 Oct 31, 2023: Exactech Announces First Surgeries Using Activit-E for Knee Replacement 163

6.69 Oct 30, 2023: Medacta Announces the Launch of GMK SpheriKA, the World’s First Knee Implant Optimized for Kinematic Alignment (KA) 163

6.70 Oct 30, 2023: Japan Medical Dynamic Marketing Announces Consolidated Financial Results for the Second Quarter of the Fiscal Year Ending March 2024 164

6.71 Oct 27, 2023: Episurf Medical Interim Report 1 January – 30 September 2023 165

6.72 Oct 26, 2023: 3D Printing Pioneer Materialise Appoints Brigitte de Vet-Veithen as New CEO 166

6.73 Oct 25, 2023: HSS Appoints New Leadership in Neurology and Anesthesia 167

6.74 Oct 23, 2023: Think Surgical’s TMINI System Receives FDA Special 510(K) Clearance for Use With Additional Implants 167

6.75 Oct 12, 2023: MicroPort Orthopedics Receives 510(K) Clearance for EVOLUTION Hinge Knee System 168

6.76 Oct 09, 2023: Stryker to Host Investor Day 168

6.77 Oct 05, 2023: Enovis to Showcase New Surgical Innovations at AAHKS Annual Meeting 168

6.78 Oct 04, 2023: Medtronic Names Paolo Di Vincenzo President of the Neuromodulation Business 168

6.79 Oct 02, 2023: Stryker to Announce Financial Results for Its Third Quarter of Fiscal Year 2023 169

6.80 Sep 27, 2023: Washington Hospital Healthcare System First to Use Tmini Miniature Robotic System From Think Surgical 169

6.81 Sep 25, 2023: Episealer Presentations at Several Clinical Congresses 170

6.82 Sep 22, 2023: Exactech’s Activit-E polyethylene receives US FDA clearance 170

6.83 Sep 21, 2023: Stryker’s Triathlon Tritanium Baseplate Marks a Decade of Positive Patient Impact 171

6.84 Sep 20, 2023: MicroPort Orthopedics Releases Renowned Speaker Lineup for Second Annual Global Medial-Pivot Symposium 171

6.85 Sep 14, 2023: Smith & Nephew Brings BT Chief Financial Officer Simon Lowth to Board 172

6.86 Sep 14, 2023: New Non Executive Directors Join the Board at Med Tech Business 172

6.87 Sep 14, 2023: Smith & Nephew Announces Board Changes 172

6.88 Sep 12, 2023: Orthofix Announces Leadership Changes 173

6.89 Sep 05, 2023: Exactech Debuts New Primary Knee System: TriVerse 174

6.90 Sep 05, 2023: Zimmer Biomet Announces Key Updates to Company’s Executive Leadership Team 175

6.91 Aug 29, 2023: Luna Pathways Improves Postoperative Care: Patient Journey and Clinical Outcomes Outperform the Industry 175

6.92 Aug 26, 2023: Medtronic Q2 2024 Earnings Estimates Increased by William Blair 176

6.93 Aug 23, 2023: Episurf Medical: First Commercial Case in the US Scheduled 176

6.94 Aug 22, 2023: Zimmer Biomet Announces Leadership Transition 177

6.95 Aug 21, 2023: Exactech Announces FDA 510(k) Clearance For Advanced Activit-e Knee Replacement Polyethylene 178

6.96 Aug 16, 2023: Novel Combination of Oral Ketamine and Aspirin Is Safe Form of Pain Medication after Total Knee Replacement Surgery 178

6.97 Aug 09, 2023: Beijing Chunlizhengda Medical Instruments Co. Announces Annual Report for the Year Ended 31 December 2022 179

6.98 Aug 08, 2023: Medtronic to Announce Financial Results for its First Quarter of Fiscal Year 2024 180

6.99 Aug 07, 2023: Healthpoint celebrates milestone of 100 robotically assisted surgeries 180

6.100 Aug 02, 2023: Conformis Reports Second Quarter 2023 Financial Results 181

6.101 Jul 31, 2023: Exactech Receives 510(k) Clearance for TRULIANT E-PX Tibial Insert 182

6.102 Jul 31, 2023: ConforMIS Receives an Additional 510(k) Clearance for Identity Imprint Knee Replacement System 182

6.103 Jul 31, 2023: ConforMIS Receives an Additional 510(k) Clearance for iTotal Identity Cruciate Retaining Knee Replacement System 183

6.104 Jul 31, 2023: Results From the Use of Episealer Accepted for Publication in Scientific Journal 183

6.105 Jul 28, 2023: Medacta Group Announces 2023 Half-Year Unaudited Top-Line Figures 183

6.106 Jul 28, 2023: Japan Medical Dynamic Marketing Announces Summary of Consolidated Financial Results for the First Quarter of the Fiscal Year Ending March 2024 184

6.107 Jul 27, 2023: ConforMIS Receives 510(K) Clearance for Identity Imprint Porous Total Knee Replacement System 186

6.108 Jul 27, 2023: ConforMIS Receives 510(K) Clearance for Identity Imprint Porous Cruciate Retaining Total Knee Replacement System 186

6.109 Jul 19, 2023: Nicklaus Children’s is First Pediatric Hospital in South Florida to Offer Innovative BEAR Implant to Treat ACL Tears 186

6.110 Jul 17, 2023: Overture Resurfacing Receives 510(k) Clearance for Orthopedics Patellofemoral System 187

6.111 Jul 14, 2023: Episurf Medical: Strategy Update to Take the Next Commercial Steps and Improve Financial Results 187

6.112 Jul 13, 2023: Enztec Receives 510(k) Clearance for RI.KNEE Adjustable Tibia Cut Guide 188

6.113 Jul 07, 2023: Episurf Medical’s first US VAC Approval 188

6.114 Jun 27, 2023: ForCast Orthopedics Receives Orphan Drug Designation From FDA for the Treatment of Periprosthetic Joint Infection (PJI) 189

6.115 Jun 26, 2023: Medacta International Receives 510(k) Clearance for MyKnee UNI-ST 189

6.116 Jun 22, 2023: TMINI miniature robotic system secures 510(k) FDA clearance 189

6.117 Jun 22, 2023: Global Medical Technology Leader Zimmer Biomet Increases Presence in Malaysia With a New Office and GBS Center 190

6.118 Jun 20, 2023: Howmedica Osteonics Receives 510(k) Clearance for Triathlon Pro Posterior Stabilized (PS) Femoral Component 191

7 Appendix 192

7.1 Methodology 192

7.2 About GlobalData 195

7.3 Contact Us 195

7.4 Disclaimer 195

Table

Knee Reconstruction – Pipeline Products by Stage of Development 17

Knee Reconstruction – Pipeline Products by Segment 18

Knee Reconstruction – Pipeline Products by Territory 19

Knee Reconstruction – Pipeline Products by Regulatory Path 20

Knee Reconstruction – Pipeline Products by Estimated Approval Date 21

Knee Reconstruction – Ongoing Clinical Trials 22

Knee Reconstruction Companies – Pipeline Products by Stage of Development 23

Knee Reconstruction – Pipeline Products by Stage of Development 26

4WEB Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 29

Truss Implant – Knee Procedures – Product Status 29

Truss Implant – Knee Procedures – Product Description 29

Active Implants LLC Pipeline Products & Ongoing Clinical Trials Overview 30

NUsurface Meniscus Implant – Product Status 30

NUsurface Meniscus Implant – Product Description 30

Active Implants LLC – Ongoing Clinical Trials Overview 31

NUsurface Meniscus Implant – A Long-term Non-interventional Registry Study to Assess the Effectiveness and Safety of the NUsurface Meniscus Implant 32

NUsurface Meniscus Implant – The SUN Clinical Trial (Safety Utilizing NUsurface Meniscus Implant). A Multi-center, Single-arm, Prospective, Open-label, Non-randomized, Observational Clinical Study 33

Artimplant AB (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 34

Knee Resurfacing Implant – Product Status 34

Knee Resurfacing Implant – Product Description 34

Aspect Biosystems Ltd Pipeline Products & Ongoing Clinical Trials Overview 35

3D Bioprinted Meniscus Tissue – Product Status 35

3D Bioprinted Meniscus Tissue – Product Description 35

B. Braun Melsungen AG Pipeline Products & Ongoing Clinical Trials Overview 36

Biological Knee Regeneration Device – Product Status 36

Biological Knee Regeneration Device – Product Description 36

Bactiguard Holding AB Pipeline Products & Ongoing Clinical Trials Overview 37

Bactiguard Knee Joint Reconstruction Implant – Product Status 37

Bactiguard Knee Joint Reconstruction Implant – Product Description 37

Binghamton University Pipeline Products & Ongoing Clinical Trials Overview 38

Smart Knee Implant – Product Status 38

Smart Knee Implant – Product Description 38

BioPoly LLC Pipeline Products & Ongoing Clinical Trials Overview 39

BioPoly RS Partial Resurfacing Femoral System – Product Status 39

BioPoly RS Partial Resurfacing Femoral System – Product Description 39

Biopoly RS Partial Resurfacing Knee – Product Status 40

Biopoly RS Partial Resurfacing Knee – Product Description 40

BioPoly RS Partial Resurfacing Patella – Product Status 40

BioPoly RS Partial Resurfacing Patella – Product Description 41

BioPoly RS Partial Resurfacing Trochlea System – Product Status 41

BioPoly RS Partial Resurfacing Trochlea System – Product Description 41

BioPoly LLC – Ongoing Clinical Trials Overview 42

BioPoly RS Partial Resurfacing Patella – Open Label, Prospective, Consecutive Series Registry Database of Biopoly RS Partial Resurfacing Patella Implant 43

Bonovo Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 44

JMM Total Knee System – Product Status 44

JMM Total Knee System – Product Description 44

CEA-Leti Pipeline Products & Ongoing Clinical Trials Overview 45

FollowKnee – Product Status 45

FollowKnee – Product Description 45

CeramTec GmbH Pipeline Products & Ongoing Clinical Trials Overview 46

BIOLOX Delta – Knee – Product Status 46

BIOLOX Delta – Knee – Product Description 46

Clemson University Pipeline Products & Ongoing Clinical Trials Overview 47

Engage Knee System – Product Status 47

Engage Knee System – Product Description 47

Columbia University Irving Medical Center Pipeline Products & Ongoing Clinical Trials Overview 48

NOVAJoint – Product Status 48

NOVAJoint – Product Description 48

ConforMIS Inc Pipeline Products & Ongoing Clinical Trials Overview 49

ASC Cementless Knee Replacement System – Product Status 49

ASC Cementless Knee Replacement System – Product Description 49

ASC Knee Replacement System – Product Status 50

ASC Knee Replacement System – Product Description 50

Constrained Poly-CS – Product Status 50

Constrained Poly-CS – Product Description 51

Constrained Poly-PS – Product Status 51

Constrained Poly-PS – Product Description 51

Identity Cementless System – Product Status 51

Identity Cementless System – Product Description 52

OsteoSync Ti – Cementless Total Knee Replacement – Product Status 52

OsteoSync Ti – Cementless Total Knee Replacement – Product Description 52

Corin Group Ltd Pipeline Products & Ongoing Clinical Trials Overview 53

IL-Knee – Product Status 53

IL-Knee – Product Description 53

IL-Knee 1 – Product Status 54

IL-Knee 1 – Product Description 54

IL-Knee 2 – Product Status 54

IL-Knee 2 – Product Description 54

CytexOrtho Pipeline Products & Ongoing Clinical Trials Overview 55

Bio-Artificial Cartilage Implant – Knee Repair – Product Status 55

Bio-Artificial Cartilage Implant – Knee Repair – Product Description 55

Delta Orthopedics LLC Pipeline Products & Ongoing Clinical Trials Overview 56

Hinge Knee System – Product Status 56

Hinge Knee System – Product Description 56

DiFusion Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 57

ACL Repair Screw – Product Status 57

ACL Repair Screw – Product Description 57

Ecole de technologie superieure Pipeline Products & Ongoing Clinical Trials Overview 58

Knee Resurfacing Implant – Product Status 58

Knee Resurfacing Implant – Product Description 58

Elite Surgical Supplies (Pty) Ltd Pipeline Products & Ongoing Clinical Trials Overview 59

UNIQ PARTIAL KNEE – Product Status 59

UNIQ PARTIAL KNEE – Product Description 59

Episurf Medical AB Pipeline Products & Ongoing Clinical Trials Overview 60

Episealer Condyle Solo – Product Status 60

Episealer Condyle Solo – Product Description 60

Episealer Femoral Twin – Product Status 61

Episealer Femoral Twin – Product Description 61

Episealer Trochlea Solo – Product Status 61

Episealer Trochlea Solo – Product Description 62

Episurf Medical AB – Ongoing Clinical Trials Overview 63

Episealer Condyle Solo – A Prospective, Randomized, Controlled, Multi-center Study to Evaluate the Safety and Effectiveness of the Episealer Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions 64

Episealer Condyle Solo – Efficacy of Focal Individualised Mini-metal Implant in Treatment of Focal Cartilage Lesions in the Knee 64

Episealer Condyle Solo – Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant 64

Episealer Condyle Solo – X-ray Fluoroscopic Analysis of Knee Joint Kinematic in Open and Closed Chain Activities in Patients with Episealer Knee Implants 65

Episealer Trochlea Solo – A Prospective, Randomized, Controlled, Multi-center Study to Evaluate the Safety and Effectiveness of the Episealer Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions 66

Episealer Trochlea Solo – An Investigator-initiated European Multi-center Study of Episealer in Knee Patients 66

Episealer Trochlea Solo – Efficacy of Focal Individualised Mini-metal Implant in Treatment of Focal Cartilage Lesions in the Knee 66

Episealer Trochlea Solo – Long-term Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant 67

Episealer Trochlea Solo – X-ray Fluoroscopic Analysis of Knee Joint Kinematic in Open and Closed Chain Activities in Patients with Episealer Knee Implants 67

Episealer Femoral Twin – A Prospective, Randomized, Controlled, Multi-center Study to Evaluate the Safety and Effectiveness of the Episealer Knee System Compared to Microfracture for the Treatment of Focal Femoral Knee Chondral or Osteochondral Lesions 68

Episealer Femoral Twin – Efficacy of Focal Individualised Mini-metal Implant in Treatment of Focal Cartilage Lesions in the Knee 68

Episealer Femoral Twin – X-ray Fluoroscopic Analysis of Knee Joint Kinematic in Open and Closed Chain Activities in Patients with Episealer Knee Implants 68

Exactech Inc Pipeline Products & Ongoing Clinical Trials Overview 69

Activit-E Polyethylene – Product Status 69

Activit-E Polyethylene – Product Description 69

Adv. Ligament Balancing System – Product Status 70

Adv. Ligament Balancing System – Product Description 70

Exactech GPS CC System – Product Status 70

Exactech GPS CC System – Product Description 71

Exactech GPS Uni System – Product Status 71

Exactech GPS Uni System – Product Description 71

One Logic Patella System – Product Status 72

One Logic Patella System – Product Description 72

Optetrak Logic RBK (Rotating Bearing Knee) System – Product Status 72

Optetrak Logic RBK (Rotating Bearing Knee) System – Product Description 73

Optetrak Logic Unicondylar System – Product Status 73

Optetrak Logic Unicondylar System – Product Description 73

EZ ORTHOPEDICS ISRAEL Pipeline Products & Ongoing Clinical Trials Overview 74

EZ KneeSpan – Product Status 74

EZ KneeSpan – Product Description 74

ForCast Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 75

Antibiotic Dispensing Spacer – Product Status 75

Antibiotic Dispensing Spacer – Product Description 75

Fuse Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 76

Revision Knee System – Product Status 76

Revision Knee System – Product Description 76

Ganymed Robotics SAS Pipeline Products & Ongoing Clinical Trials Overview 77

Therapeutic Device – Total Knee Arthroplasty – Product Status 77

Therapeutic Device – Total Knee Arthroplasty – Product Description 77

Genovel Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 78

Anatomical Knee – Product Status 78

Anatomical Knee – Product Description 78

Mini-Knee – Product Status 79

Mini-Knee – Product Description 79

Georgia Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 80

Artificial Meniscus Implant – Product Status 80

Artificial Meniscus Implant – Product Description 80

Hospital for Special Surgery Pipeline Products & Ongoing Clinical Trials Overview 81

Revision Knee System – Product Status 81

Revision Knee System – Product Description 81

Unicompartmental Tibial Cutting Guide – Product Status 82

Unicompartmental Tibial Cutting Guide – Product Description 82

Indian Institute of Technology Bombay Pipeline Products & Ongoing Clinical Trials Overview 83

Modular Knee Joint Implant – Product Status 83

Modular Knee Joint Implant – Product Description 83

Invibio Knee Ltd Pipeline Products & Ongoing Clinical Trials Overview 84

PEEK-OPTIMA Femoral Knee Replacement Device – Product Status 84

PEEK-OPTIMA Femoral Knee Replacement Device – Product Description 84

Invibio Knee Ltd – Ongoing Clinical Trials Overview 85

PEEK-OPTIMA Femoral Knee Replacement Device – A Multi-center Clinical Investigation to Evaluate the Safety and Performance of the Freedom Total Knee System with the PEEK-OPTIMA Femoral Component 86

Kinamed Inc Pipeline Products & Ongoing Clinical Trials Overview 87

GEM – Total Knee System – Product Status 87

GEM – Total Knee System – Product Description 87

Materialise NV Pipeline Products & Ongoing Clinical Trials Overview 88

X-ray Knee Guide System – Product Status 88

X-ray Knee Guide System – Product Description 88

Materials Mines Paris Tech Center Pipeline Products & Ongoing Clinical Trials Overview 89

Ligagel – Product Status 89

Ligagel – Product Description 89

Medacta Group SA Pipeline Products & Ongoing Clinical Trials Overview 90

Medacta TiNbN Coated Partial Knee System – Product Status 90

Medacta TiNbN Coated Partial Knee System – Product Description 90

MicroPort Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 91

Evolution Localization System – Product Status 91

Evolution Localization System – Product Description 91

Next Generation Prophecy Gap Balancing System – Product Status 92

Next Generation Prophecy Gap Balancing System – Product Description 92

Uni-Corn Fix Bearing – Product Status 92

Uni-Corn Fix Bearing – Product Description 93

MicroPort Orthopedics Inc – Ongoing Clinical Trials Overview 94

Evolution Localization System – Component Migration, Polyethylene Wear, and Joint Inflammation of the Evolution Versus Evolution NitrX Total Knee Arthroplasty System 95

MicroPort Scientific Corp Pipeline Products & Ongoing Clinical Trials Overview 96

Femoral Condyle – Product Status 96

Femoral Condyle – Product Description 96

Hinged Knee Joint System – Product Status 97

Hinged Knee Joint System – Product Description 97

Knee Revision System – Product Status 97

Knee Revision System – Product Description 97

Medial-Pivot III Knee System – Product Status 98

Medial-Pivot III Knee System – Product Description 98

Nano Interface Technology LLC (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 99

Knee Implant – Product Status 99

Knee Implant – Product Description 99

NovoPedics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 100

Meniscofix – Product Status 100

Meniscofix – Product Description 100

Ohio State University Pipeline Products & Ongoing Clinical Trials Overview 101

Joint Stability Measurement Device – Product Status 101

Joint Stability Measurement Device – Product Description 101

Okani Medical Technology Pipeline Products & Ongoing Clinical Trials Overview 102

ORGKnee Implant – Product Status 102

ORGKnee Implant – Product Description 102

OrthoGrid Systems Inc Pipeline Products & Ongoing Clinical Trials Overview 103

KneeFXGrid – Product Status 103

KneeFXGrid – Product Description 103

Orthonika Ltd Pipeline Products & Ongoing Clinical Trials Overview 104

MenisciKnit – Product Status 104

MenisciKnit – Product Description 104

OrthoSensor Inc Pipeline Products & Ongoing Clinical Trials Overview 105

OrthoSensor Microelectronic Implant – Product Status 105

OrthoSensor Microelectronic Implant – Product Description 105

Resultados y Calidad del Sistema Sanitario Publico de Andalucia Pipeline Products & Ongoing Clinical Trials Overview 106

Knee Replacement Implant – Product Status 106

Knee Replacement Implant – Product Description 106

Secondary Knee Prosthesis – Product Status 107

Secondary Knee Prosthesis – Product Description 107

RIH Orthopaedic Foundation Inc Pipeline Products & Ongoing Clinical Trials Overview 108

TruTarget System – Product Status 108

TruTarget System – Product Description 108

Sanatmetal Ltd. Pipeline Products & Ongoing Clinical Trials Overview 109

Sanatmetal’s Knee Joint Replacement System – Product Status 109

Sanatmetal’s Knee Joint Replacement System – Product Description 109

Sensortech Corp Pipeline Products & Ongoing Clinical Trials Overview 110

Force Check Knee Replacement Smart Insert – Product Status 110

Force Check Knee Replacement Smart Insert – Product Description 110

SINTX Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 111

Total Knee Implant – Product Status 111

Total Knee Implant – Product Description 111

Smith & Nephew Plc Pipeline Products & Ongoing Clinical Trials Overview 112

LEGION RH Hinge – Product Status 112

LEGION RH Hinge – Product Description 112

Robotics-Assisted Revision Knee System – Product Status 113

Robotics-Assisted Revision Knee System – Product Description 113

Total Knee Arthroplasty Instrument – Product Status 113

Total Knee Arthroplasty Instrument – Product Description 113

Stellenbosch University Pipeline Products & Ongoing Clinical Trials Overview 114

uMove – Product Status 114

uMove – Product Description 114

Stevens Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 115

OrthoInsight – Product Status 115

OrthoInsight – Product Description 115

Think Surgical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 116

TMINI System Integrated With Freedom Knee System – Product Status 116

TMINI System Integrated With Freedom Knee System – Product Description 116

TMINI System Integrated With MOBIO Total Knee System – Product Status 117

TMINI System Integrated With MOBIO Total Knee System – Product Description 117

University of Bath Pipeline Products & Ongoing Clinical Trials Overview 118

Bespoke Implant – Product Status 118

Bespoke Implant – Product Description 118

University of Florida Pipeline Products & Ongoing Clinical Trials Overview 119

Spacer Block With Sensor – Product Status 119

Spacer Block With Sensor – Product Description 119

University of South Carolina Pipeline Products & Ongoing Clinical Trials Overview 120

Lockable Knee Implant – Product Status 120

Lockable Knee Implant – Product Description 120

Zimmer Biomet Holdings Inc Pipeline Products & Ongoing Clinical Trials Overview 121

PIQ Next Generation – Product Status 121

PIQ Next Generation – Product Description 121

ZKR Orthopedics Inc Pipeline Products & Ongoing Clinical Trials Overview 122

LIFT Implant – Product Status 122

LIFT Implant – Product Description 122

ZKR Orthopedics Inc – Ongoing Clinical Trials Overview 123

LIFT Implant – A Pivotal Study to Evaluate the Performance of the LIFT Implant Technology Compared to Tibial Tubercle Osteotomy in Subjects with Cartilage Degeneration and Osteoarthritis of the Knee 124

Glossary 194

Figures

Knee Reconstruction – Pipeline Products by Stage of Development 16

Knee Reconstruction – Pipeline Products by Segment 17

Knee Reconstruction – Pipeline Products by Territory 18

Knee Reconstruction – Pipeline Products by Regulatory Path 19

Knee Reconstruction – Pipeline Products by Estimated Approval Date 20

Knee Reconstruction – Ongoing Clinical Trials 21

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