Left Atrial Appendage Closure Devices Pipeline by Development Stages, Segments, Region and Countries, Regulatory Path and Key Companies

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Published: March 29, 2024 Report Code: GDME1721EPD-ST

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Left Atrial Appendage Closure Devices Pipeline Market Report Overview

Left atrial appendage closure device prevents blood flow into the left atrial appendage, preventing blood clotting or pooling. It consists of left atrial appendage implanted occlusion devices and left atrial appendage ligation devices. One unit refers to one left atrial appendage closure device.

The left atrial appendage closure devices pipeline market research report provides a comprehensive understanding of the pipeline products along with their comparative analysis at various stages of development. The report also includes information about the territories wherein the clinical trials are in progress, the regulatory paths followed by the trials, and the companies associated with the trials.

Key Territories ·        United States

·        China

·        Israel

·        Japan

·        Canada
Key Regulatory Paths ·        PMA

·        NMPA

·        MDL

·        Shonin

·        TGA
Key Companies ·        Abbott Medical

·        Aegis Medical Innovations Inc.

·        Append Medical

·        AuriGen Medical Ltd

·        Boston Scientific Corp
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Left Atrial Appendage Closure Devices Pipeline Market Segmentation by Territories

A few of the key territories for the left atrial appendage closure devices pipeline market are the United States, China, Israel, Japan, and Canada. As of March 2024, the United States accounted for the highest number of pipeline products.

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Territories, 2024 (%)

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Territories, 2024 (%)

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Left Atrial Appendage Closure Devices Pipeline Market Segmentation by Regulatory Paths

The key regulatory paths in the left atrial appendage closure devices pipeline products market are PMA, NMPA, MDL, Shonin, TGA among others. As of March 2024, PMA was the most followed pathway for pipeline products in the market.

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Regulatory Paths, 2024 (%)

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Regulatory Paths, 2024 (%)

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Left Atrial Appendage Closure Devices Pipeline Market – Competitive Landscape

A few of the key companies associated with the left atrial appendage closure devices pipeline market are Abbott Medical, Aegis Medical Innovations Inc., Append Medical, AuriGen Medical Ltd, Boston Scientific Corp among others.

Append Medical: It is a Pharmaceuticals and Healthcare company offers healthcare services and develops a next-generation transcatheter left atrial appendage (LAA) closure system. Append Medical is Headquartered in Or Yehuda, Israel.

Boston Scientific Corp: Boston Scientific Corp (Boston Scientific) is a medical technology company that develops, manufactures, and commercializes devices for a range of interventional medical specialties. The company offers products in the areas of electrophysiology, gastroenterology among others. Boston Scientific serves hospitals, clinics, outpatient facilities, and medical offices across the world.

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Companies, 2024

Left Atrial Appendage Closure Devices Pipeline Market Analysis by Companies, 2024

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Segments Covered in the Report

Left Atrial Appendage Closure Devices Pipeline Market Territories Outlook

  • United States
  • China
  • Israel
  • Japan
  • Canada

Left Atrial Appendage Closure Devices Pipeline Market Regulatory Paths Outlook

  • PMA
  • NMPA
  • MDL
  • Shonin
  • TGA

Scope

This report provides:

  • Extensive coverage of the left atrial appendage closure devices under development.

  • Exhaustive list of major pipeline products and their details, including product description, licensing and collaboration details, and other developmental activities.

  • Reviews of major players involved in the development of left atrial appendage closure devices and lists all their pipeline projects.

  • Coverage of pipeline products based on various stages of development ranging from early development to approved/issued stage.

  • Key clinical trial data of ongoing clinical trials specific to pipeline products.

  • Recent developments in the segment/industry.

Reasons to Buy

  • Formulate significant competitor information, analysis, and insights to improve R&D strategies.

  • Identify emerging players with potentially strong product portfolios and create effective counter strategies to gain a competitive advantage.

  • Identify and understand important and diverse types of left atrial appendage closure devices under development.

  • Develop market-entry and market-expansion strategies.

  • Plan mergers and acquisitions effectively by identifying major players with the most promising pipeline.

  • Carry out an in-depth analysis of the product’s current stage of development, territory, and estimated launch date.

Abbott Medical
Aegis Medical Innovations Inc.
Append Medical
AuriGen Medical Ltd
Boston Scientific Corp
Conformal Medical Inc
Cor Habere Corp
Hangzhou Denuo Electrophysiology Medical Technology Co Ltd
Hansen Medical Inc (Inactive)
Jenscare Scientific Co Ltd
Johnson & Johnson
Lepu Scientech Medical Technology (Shanghai) Co Ltd
Lifetech Scientific (Shenzhen) Co Ltd
LuSeed Vascular
Mayo Clinic
Medtronic Plc
Northwestern University
SentreHEART Inc
Shanghai Shenqi Medical Technology Co Ltd
The Chaim Sheba Medical Center

Table of Contents

1 Table of Contents 3

1.1 List of Tables 5

1.2 List of Figures 7

2 Introduction 8

2.1 Left Atrial Appendage Closure Devices Overview 8

3 Products under Development 9

3.1 Left Atrial Appendage Closure Devices – Pipeline Products by Stage of Development 9

3.2 Left Atrial Appendage Closure Devices – Pipeline Products by Territory 10

3.3 Left Atrial Appendage Closure Devices – Pipeline Products by Regulatory Path 11

3.4 Left Atrial Appendage Closure Devices – Pipeline Products by Estimated Approval Date 12

3.5 Left Atrial Appendage Closure Devices – Ongoing Clinical Trials 13

4 Left Atrial Appendage Closure Devices – Pipeline Products under Development by Companies 14

4.1 Left Atrial Appendage Closure Devices Companies – Pipeline Products by Stage of Development 14

4.2 Left Atrial Appendage Closure Devices – Pipeline Products by Stage of Development 15

5 Left Atrial Appendage Closure Devices Companies and Product Overview 16

5.1 Abbott Medical Company Overview 16

5.1.1 Abbott Medical Pipeline Products & Ongoing Clinical Trials Overview 16

5.2 Aegis Medical Innovations Inc. Company Overview 17

5.2.1 Aegis Medical Innovations Inc. Pipeline Products & Ongoing Clinical Trials Overview 17

5.3 Append Medical Company Overview 18

5.3.1 Append Medical Pipeline Products & Ongoing Clinical Trials Overview 18

5.4 AuriGen Medical Ltd Company Overview 19

5.4.1 AuriGen Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview 19

5.5 Boston Scientific Corp Company Overview 21

5.5.1 Boston Scientific Corp Pipeline Products & Ongoing Clinical Trials Overview 21

5.6 Conformal Medical Inc Company Overview 23

5.6.1 Conformal Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 23

5.7 Cor Habere Corp Company Overview 27

5.7.1 Cor Habere Corp Pipeline Products & Ongoing Clinical Trials Overview 27

5.8 Hangzhou Denuo Electrophysiology Medical Technology Co Ltd Company Overview 28

5.8.1 Hangzhou Denuo Electrophysiology Medical Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 28

5.9 Hansen Medical Inc (Inactive) Company Overview 29

5.9.1 Hansen Medical Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 29

5.10 Jenscare Scientific Co Ltd Company Overview 30

5.10.1 Jenscare Scientific Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 30

5.11 Johnson & Johnson Company Overview 31

5.11.1 Johnson & Johnson Pipeline Products & Ongoing Clinical Trials Overview 31

5.12 Lepu Scientech Medical Technology (Shanghai) Co Ltd Company Overview 34

5.12.1 Lepu Scientech Medical Technology (Shanghai) Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 34

5.13 Lifetech Scientific (Shenzhen) Co Ltd Company Overview 35

5.13.1 Lifetech Scientific (Shenzhen) Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 35

5.14 LuSeed Vascular Company Overview 39

5.14.1 LuSeed Vascular Pipeline Products & Ongoing Clinical Trials Overview 39

5.15 Mayo Clinic Company Overview 40

5.15.1 Mayo Clinic Pipeline Products & Ongoing Clinical Trials Overview 40

5.16 Medtronic Plc Company Overview 41

5.16.1 Medtronic Plc Pipeline Products & Ongoing Clinical Trials Overview 41

5.17 Northwestern University Company Overview 42

5.17.1 Northwestern University Pipeline Products & Ongoing Clinical Trials Overview 42

5.18 SentreHEART Inc Company Overview 43

5.18.1 SentreHEART Inc Pipeline Products & Ongoing Clinical Trials Overview 43

5.19 Shanghai Shenqi Medical Technology Co Ltd Company Overview 45

5.19.1 Shanghai Shenqi Medical Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 45

5.20 The Chaim Sheba Medical Center Company Overview 46

5.20.1 The Chaim Sheba Medical Center Pipeline Products & Ongoing Clinical Trials Overview 46

6 Left Atrial Appendage Closure Devices- Recent Developments 47

6.1 Mar 13, 2024: Conformal Medical’s CLAAS System Demonstrates Low Thrombogenicity Compared to Commercially Available LAAO Devices 47

6.2 Feb 06, 2024: The CLAAS System by Conformal Medical Demonstrates Sizing Simplicity and Seal Efficiency During AF Symposium Live Case Presentation 47

6.3 Feb 02, 2024: MicroPort CardioFlow Receives Approval for Its AnchorMan LAAC System in China 48

6.4 Nov 13, 2023: Jenscare : Simulock Successfully Completes Implantation Surgery for the First Confirmatory Clinical Trial 49

6.5 Oct 24, 2023: Conformal Medical Announces Compelling One-Year Data from its Left Atrial Appendage Occlusion (LAAO) Early Feasibility Study 49

6.6 Oct 24, 2023: Cleveland Clinic-Led Trial Finds that Atrial Fibrillation Patients Undergoing TAVR and Watchman Procedures Together Have Similar Outcomes to Using Blood Thinners after TAVR 50

6.7 Sep 07, 2023: Boston Scientific’s LAAC device gets FDA approval 51

6.8 Sep 06, 2023: Boston Scientific Announces FDA Approval for the Latest-Generation WATCHMAN FLX Pro Left Atrial Appendage Closure Device 51

7 Appendix 53

7.1 Methodology 53

7.2 About GlobalData 56

7.3 Contact Us 56

7.4 Disclaimer 56

Table

Left Atrial Appendage Closure Devices – Pipeline Products by Stage of Development 9

Left Atrial Appendage Closure Devices – Pipeline Products by Territory 10

Left Atrial Appendage Closure Devices – Pipeline Products by Regulatory Path 11

Left Atrial Appendage Closure Devices – Pipeline Products by Estimated Approval Date 12

Left Atrial Appendage Closure Devices – Ongoing Clinical Trials 13

Left Atrial Appendage Closure Devices Companies – Pipeline Products by Stage of Development 14

Left Atrial Appendage Closure Devices – Pipeline Products by Stage of Development 15

Abbott Medical Pipeline Products & Ongoing Clinical Trials Overview 16

AMJ-505 Left Atrial Appendage Occlusion System – Product Status 16

AMJ-505 Left Atrial Appendage Occlusion System – Product Description 16

Aegis Medical Innovations Inc. Pipeline Products & Ongoing Clinical Trials Overview 17

Aegis Sierra Ligation System – Product Status 17

Aegis Sierra Ligation System – Product Description 17

Append Medical Pipeline Products & Ongoing Clinical Trials Overview 18

Appligator – Product Status 18

Appligator – Product Description 18

AuriGen Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview 19

12F Aurigen Delivery System – Product Status 19

12F Aurigen Delivery System – Product Description 19

Zenith LAA Occlusion System – Product Status 20

Zenith LAA Occlusion System – Product Description 20

Boston Scientific Corp Pipeline Products & Ongoing Clinical Trials Overview 21

AnchorMan Left Atrial Appendage Closure – Product Status 21

AnchorMan Left Atrial Appendage Closure – Product Description 21

WATCHMAN FLX Pro – Product Status 22

WATCHMAN FLX Pro – Product Description 22

Conformal Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 23

CLAAS Device – Product Status 23

CLAAS Device – Product Description 23

Conformal Medical Inc – Ongoing Clinical Trials Overview 24

CLAAS Device – An Evaluation of the Safety and Effectiveness of the Conformal CLAAS System for Left Atrial Appendage Occlusion 25

CLAAS Device – The CONFORMAL Early Feasibility Study an Evaluation of the Safety and Performance of the Conformal Left Atrial Appendage Seal for Left Atrial Appendage Occlusion 25

CLAAS Device – The Conformal Prague Study: An Evaluation of the Safety and Performance of the Conformal Left Atrial Appendage Seal for Left Atrial Appendage Occlusion 25

CLAAS Device – The Conscious Sedation Single Arm Sub-Study 26

Cor Habere Corp Pipeline Products & Ongoing Clinical Trials Overview 27

StrokeShield System – Product Status 27

StrokeShield System – Product Description 27

Hangzhou Denuo Electrophysiology Medical Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 28

E-SeaLA – Product Status 28

E-SeaLA – Product Description 28

Hansen Medical Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 29

Sensei Robotic Catheter System – LAA – Product Status 29

Sensei Robotic Catheter System – LAA – Product Description 29

Jenscare Scientific Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 30

SimuLock – Product Status 30

SimuLock – Product Description 30

Johnson & Johnson Pipeline Products & Ongoing Clinical Trials Overview 31

Laminar Left Atrial Appendage Closure System – Product Status 31

Laminar Left Atrial Appendage Closure System – Product Description 31

Johnson & Johnson – Ongoing Clinical Trials Overview 32

Laminar Left Atrial Appendage Closure System – A Trial Evaluating the Safety and Effectiveness of the Laminar Left Atrial Appendage Closure System in Subjects with Non- Valvular Atrial Fibrillation 33

Laminar Left Atrial Appendage Closure System – An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects with Non-Valvular Atrial Fibrillation 33

Laminar Left Atrial Appendage Closure System – Laminar Left Atrial Appendage Elimination (LAAX) Pivotal IDE Study 33

Lepu Scientech Medical Technology (Shanghai) Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 34

LAA Closure Occluder II – Product Status 34

LAA Closure Occluder II – Product Description 34

Lifetech Scientific (Shenzhen) Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 35

LAmbre LAA Closure System – Product Status 35

LAmbre LAA Closure System – Product Description 35

Lifetech Scientific (Shenzhen) Co Ltd – Ongoing Clinical Trials Overview 36

LAmbre LAA Closure System – Can the Lambre Device Occlude IRRegular And Large Appendages in Patients With Non-Valvular AF: The CORRAL-AF Study 37

LAmbre LAA Closure System – LAmbre Versus AMPLATZER Amulet Left Atrial Appendage Occluder for Stroke Prophylaxis: The Randomized AMPIRI Trial 37

LAmbre LAA Closure System – LifeTech LAmbre Keft Atrial Appendage (LAA) Closure System Post-market Clinical Follow-up 37

LAmbre LAA Closure System – Lifetech LAmbre Left Atrial Appendage Closure System Post-Market Clinical Follow-up Multi-center, Single-arm, Prospective, Post-market study 38

LAmbre LAA Closure System – Lifetech Lambre Left Atrial Appendage Closure System Post-market Registry Single-center, Single-arm, Prospective, Post-market Registry 38

LAmbre LAA Closure System – Safety and Efficacy Study of LAmbre Plus LAA occluder System in Non-valvular Atrial Fibrillation Patients 38

LuSeed Vascular Pipeline Products & Ongoing Clinical Trials Overview 39

LuSeed Intrasaccular Device – LAA Occlusion – Product Status 39

LuSeed Intrasaccular Device – LAA Occlusion – Product Description 39

Mayo Clinic Pipeline Products & Ongoing Clinical Trials Overview 40

Left Atrial Appendage Closure Device – Product Status 40

Left Atrial Appendage Closure Device – Product Description 40

Medtronic Plc Pipeline Products & Ongoing Clinical Trials Overview 41

Cardioblate Closure LAA Occlusion Device – Product Status 41

Cardioblate Closure LAA Occlusion Device – Product Description 41

Northwestern University Pipeline Products & Ongoing Clinical Trials Overview 42

Left Atrial Appendage Occluder – Product Status 42

Left Atrial Appendage Occluder – Product Description 42

SentreHEART Inc Pipeline Products & Ongoing Clinical Trials Overview 43

Eclipse Surgical Left Atrial Appendage Closure Device – Product Status 43

Eclipse Surgical Left Atrial Appendage Closure Device – Product Description 43

LARIAT Suture Delivery Device – Adjunctive Therapy – Product Status 44

LARIAT Suture Delivery Device – Adjunctive Therapy – Product Description 44

Shanghai Shenqi Medical Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 45

Left Atrial Appendage Occluder System – Product Status 45

Left Atrial Appendage Occluder System – Product Description 45

The Chaim Sheba Medical Center Pipeline Products & Ongoing Clinical Trials Overview 46

Left Atrial Appendage Intraatrial Transcatheter Sutureless Closure – Product Status 46

Left Atrial Appendage Intraatrial Transcatheter Sutureless Closure – Product Description 46

Glossary 55

Figures

Left Atrial Appendage Closure Devices – Pipeline Products by Stage of Development 9

Left Atrial Appendage Closure Devices – Pipeline Products by Territory 10

Left Atrial Appendage Closure Devices – Pipeline Products by Regulatory Path 11

Left Atrial Appendage Closure Devices – Pipeline Products by Estimated Approval Date 12

Left Atrial Appendage Closure Devices – Ongoing Clinical Trials 13

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