Orthobiologics Pipeline Report including Stages of Development, Segments, Region and Countries, Regulatory Path and Key Companies, 2022 Update

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Orthobiologics are biomaterials used in orthopedic surgery as an adjunct to faster fusion and healing of the bone. The orthobiologics category covers bone graft substitutes, bone growth stimulators, cartilage repair and viscosupplementation products.

The orthobiologics pipeline market research report provides comprehensive information about the orthobiologics pipeline products with a comparative analysis of the products at various stages of development and information about the clinical trials which are in progress.

Orthobiologics Pipeline Products Market Segments

Bone grafts and substitutes, synthetic bone graft substitutes, cartilage repair, viscosupplementation, bone morphogenetic proteins (BMP), bone growth stimulators, soft tissue biologics, implantable bone growth stimulators, demineralized bone matrix (DBM) are some of the key segments in the pipeline product. 

 Orthobiologics Pipeline Products Market Analysis, by Segments, 2022 (%)

 Orthobiologics Pipeline Products Market Analysis, by Segments

For more segment insights into the orthobiologics pipeline products market, download a free report sample

Orthobiologics Pipeline Products Market Segmentation, by Territories 

Some of the key territories with products in the pipeline are the US, Europe, China, Canada, Taiwan, Singapore, Japan, India, Brazil, Israel, South Korea, and others. As of September 2022, the US has the highest number of products in the pipeline out of them all.

Orthobiologics Pipeline Products Market Analysis, by Territories, 2022 (%)

Orthobiologics Pipeline Products Market Analysis, by Territories 

For more territory insights into the orthobiologics pipeline products market, download a free report sample  

Orthobiologics Pipeline Products Market Segmentation by Key Regulatory Paths 

The key regulatory paths followed by the pipeline are 510(K), CE, NMPA, HSA, BOPA, ICAC, MDL, Ninsho, and TGA. Most of the products follow the 510(K) pathway to enter the market.

 Orthobiologics Pipeline Products Market Analysis, by Regulatory Paths, 2022 (%)

 Orthobiologics Pipeline Products Market Analysis, by Regulatory Paths 

For more orthobiologics pipeline regulatory path insights, download a free report sample  

Competitive Landscape 

Some of the leading companies in the orthobiologics pipeline products market are 3D Bio Corp, Abyrx, Inc., Acro Biomedical Co Lt, and Acuitive Technologies Inc.

3D Bio Corp (3D Bio): It operates as a biotechnology company that specializes in regenerative medicine and devices. The company’s pipeline products include AuriNovo, AnnuNovo, DiscNovo and NasaNovo. The company provides bio printing platform which focuses on whole-tissue living implants for near-term indications. It has lab and factory facilities in Ithaca, New York and engineering workshop in Brooklyn, New York. The company was funded by Kairos Ventures. 3D Bio is headquartered in New York, the US.

Acro Biomedical Co Ltd (Acro Biomedica): It develops and manufactures nutritional products. The company offers cordyceps fungus for medicinal purposes. It also sells cordycepin and cordyceps powder. Acro Biomedica is headquartered in Indiana, the US.

Orthobiologics Pipeline Products Market Report Overview 

KKey Segments Bone Grafts and Substitutes, Synthetic Bone Graft Substitutes, Cartilage Repair, Viscosupplementation, Bone Morphogenetic Proteins (BMP), Bone Growth Stimulators, Soft Tissue Biologics, Implantable Bone Growth Stimulators, Demineralized Bone Matrix (DBM)
KKey Territories The US, Europe, China, Canada, Taiwan, Singapore, Japan, India, Brazil, Israel, South Korea, and Others
KKey Regulatory PPaths 510(K), CE, NMPA, HSA, BOPA, ICAC, MDL, Ninsho, and TGA
LLeading Companies 3D Bio Corp, Abyrx, Inc., Acro Biomedical Co Lt, and Acuitive Technologies Inc
Key Segments Bone Grafts and Substitutes, Synthetic Bone Graft Substitutes, Cartilage Repair, Viscosupplementation, Bone Morphogenetic Proteins (BMP), Bone Growth Stimulators, Soft Tissue Biologics, Implantable Bone Growth Stimulators, Demineralized Bone Matrix (DBM)
Key Territories The US, Europe, China, Canada, Taiwan, Singapore, Japan, India, Brazil, Israel, South Korea, and Others
Key Regulatory Paths 510(K), CE, NMPA, HSA, BOPA, ICAC, MDL, Ninsho, and TGA
Leading Companies 3D Bio Corp, Abyrx, Inc., Acro Biomedical Co Lt, and Acuitive Technologies Inc

Segments Covered in the Report

Orthobiologics Pipeline Products Market Segments Outlook

  • Bone Grafts and Substitutes
  • Synthetic Bone Graft Substitutes
  • Cartilage Repair
  • Viscosupplementation
  • Bone Morphogenetic Proteins (BMP)
  • Bone Growth Stimulators
  • Soft Tissue Biologics
  • Implantable Bone Growth Stimulators
  • Demineralized Bone Matrix (DBM)

Orthobiologics Pipeline Products Market Territories Outlook

  • The US
  • Europe
  • China
  • Canada
  • Taiwan
  • Singapore
  • Japan
  • India
  • Brazil
  • Israel
  • South Korea

Orthobiologics Pipeline Products Market Regulatory Paths Outlook

  • 510(K)
  • CE
  • NMPA
  • HAS
  • BOPA
  • ICAC
  • MDL
  • Ninsho
  • TGA

Scope

This report provides:

  • Extensive coverage of orthobiologics under development.
  • The report reviews details of major pipeline products which includes, product description, licensing and collaboration details, and other developmental activities
  • The report reviews the major players involved in the development of Orthobiologics and lists all their pipeline projects
  • The coverage of pipeline products is based on various stages of development ranging from early development to the approved/issued stage.
  • The report provides key clinical trial data of ongoing trials specific to pipeline products.
  • Recent developments in the segment/industry.

Reasons to Buy

The report enables you to:

  • Formulate significant competitor information, analysis, and insights to improve R&D strategies.
  • Identify emerging players with a potentially strong product portfolio and create effective counterstrategies to gain a competitive advantage.
  • Identify and understand important and diverse types of Orthobiologics under development.
  • Develop market-entry and market-expansion strategies.
  • Plan mergers and acquisitions effectively by identifying major players with the most promising pipeline.
  • In-depth analysis of the product’s current stage of development, territory, and estimated launch date.

3D Bio Corp
Abyrx, Inc.
Acro Biomedical Co Ltd
Acuitive Technologies Inc
Adocia SAS
Advanced Biologics LLC
Aeon Astron Corporation
Aesculap Biologics LLC
Agenta Biotechnologies Inc (Inactive)
Allergan Aesthetics
Amend Surgical, Inc.
Ampio Pharmaceuticals Inc
Anika Therapeutics Inc
Antibe Therapeutics Inc
Aperion Biologics Corp
Arthro Kinetics AG
Articulate Biosciences LLC
Artimplant AB (Inactive)
Askel Healthcare Ltd
Aursos, Inc (Inactive)
Azellon Ltd
B. Braun Melsungen AG
Baxter International Inc
Ben-Gurion University of the Negev
Berkeley Advanced Biomaterials Inc
Bio2 Technologies Inc
Bioactive Bone Substitutes Plc
BioCure Inc
BioGend Therapeutics Co Ltd
Biologics 4 Life SAS
Biomatlante SA
Biomimedica, Inc.
Bionext Biotech Products Ltd.
Bioregeneration Technologies, Inc
Biorez Inc
Bio-Scaffold International Pte Ltd
Bioventus Inc
BMG Pharma SpA
BonAlive Biomaterials Ltd.
Bone Biologics Corp
Bone Sci. Bio Ltd
Bone Solutions Inc
Bone Therapeutics SA
BoneGrafix, Inc.
BoneSupport AB
Bonus BioGroup Ltd
Calcitec, Inc.
Carmell Therapeutics Corp
Carticept Medical Inc
CartiCure Ltd
Cartilage Inc
Cartiva Inc
Case Western Reserve University
CellSeed Inc
Cellulosic Biotherapeutics
Cellumed Co Ltd
Center for Biomedical Research Network in Bioengineering, Biomaterials and Nanomedicine
CeraPedics Inc
Chi2Gel Ltd.
ChitogenX Inc
Citrics Biomedical, LLC (Inactive)
Cleveland Clinic Lerner College of Medicine
Cocoon Biotech, Inc.
Collagen Solutions Ltd
Collplant Biotechnologies Ltd
Colorado Therapeutics, LLC
Connective Orthopaedics Inc (Inactive)
Contura International A/S
Core Essence Orthopaedics, LLC
CoreSpine Technologies LLC
Curative Biosciences, Inc.
Cyfuse Biomedical KK
Daewoong Pharmaceutical Co Ltd
Department of Biomedical Engineering Columbia University
DePuy Mitek, LLC
Dimension Inx LLC
DJO Global Inc
Drexel University
DSM Biomedical BV
Duke University
Eepta Pty Ltd
Eindhoven University of Technology
Element Orthopedics Inc (Inactive)
Elute Inc
ElutInc
Ember Therapeutics Inc
Embody LLC
EpiBone Inc
Eskisehir Osmangazi University
EternoGen Aesthetics LLC
Evonik Corp
Exactech Inc
ExceeMatrix (Inactive)
Ferring Pharmaceuticals AS
Flex Biomedical Inc
Formae, Inc.
Forsagen LLC
Forticell Bioscience Inc
Fuse Medical Inc
Geistlich Pharma AG
Gel-Del Technologies, Inc.
Gene Biotherapeutics Inc
George Washington University
Georgia Institute of Technology
Graftoss Limited
Graftys SA
GreenBone Ortho srl
Gunze Ltd
Hainan Susheng Biological Technology Co Ltd
Hangzhou Huamai Medical Equipment Co Ltd
Harbor MedTech Inc
Herng Shan Co Ltd
Histogen Inc
Hong Kong Polytechnic University
Hospital for Special Surgery
Hy2Care BV
Hyalex Orthopaedics Inc
Hydro-Gen LLC
iFyber LLC
Indian Institute of Technology Bombay
Induce Biologics Inc.
Industrie Biomediche Insubri SA
Inion Oy
Innovative Elements LLC
Innovia LLC
Innovoss Inc. (Inactive)
Intralink-Spine LLC
IRCCS San Raffaele Hospital
Isto Biologics
Johns Hopkins University
Kalvista Pharmaceuticals Inc
kasios sas
KeraCure, Inc. (Inactive)
Keratin Biosciences Inc
King's College London
KiOmed Pharma
Kuros Biosciences AG
Kytogenics Pharmaceuticals Inc
L&C Bio
Labrha International
Lamina Therapeutics
Lattice Biologics Ltd
LG Chem Ltd
Lineage Cell Therapeutics Inc
Locate Bio Ltd
Luna Innovations Inc
Magle Chemoswed AB
Max Biopharma Inc
Maxigen Biotech Inc
Medical Magnesium GmbH
Medisse BV (Inactive)
Medshape Inc
Medtronic Plc
Medytox Inc
MiMedx Group Inc
Miromatrix Medical Inc
Mitogen, Inc.
Mochida Pharmaceutical Co Ltd
Moebius Medical Ltd
N2 Biomedical
Nanochon LLC
National Center of Innovation for Biomaterials in Orthopaedic Research
National University of Science and Technology MiSiS
NC Biomatrix BV
NDSU Research Foundation
New York R&D Center for Translational Medicine and Therapeutics Inc
New York University
Nexxt Spine LLC
Novadip Biosciences SA
Novaicos Srls
Novatex Bioengineering SA
Novatissue SAS
NuShores Biosciences LLC
Nutech Medical Inc
NuVasive Inc
Ocugen Inc
OHSU Knight Cancer Institute
Oklahoma State University
Oligo Medic Inc
Olympus RMS Co Ltd
OPKO Health Inc
Orchestra BioMed Inc
Orteq Sports Medicine Ltd
Ortheon Medical, LLC.
Orthocell Ltd
Orthofix Medical Inc
OrthoMedex LLC
OrthoMend Research Inc
Orthosera GmbH
Orthox Ltd
OssiFi Inc
OsteoGenix Incorporated (Inactive)
OsteoNovus, LLC
Osteopore International Pte Ltd
Paras Biopharmaceuticals Finland Oy
Particle3D
PBC Biomed Ltd
Piramal Enterprises Ltd
PolarityTE Inc
PolyNovo Biomaterials Pty Ltd
PolyPid Ltd
Polytechnic University of Catalonia
Progenteq
Prohibix LLC
Promedon SA
Promimic AB
ReCaPP
REGENECURE Ltd
Regentis Biomaterials Ltd
Renovos Biologics Ltd
RepRegen Ltd. (Inactive)
Resultados y Calidad del Sistema Sanitario Publico de Andalucia
Revivicor Inc
Richard L. Roudebush VAMC
ROKIT Healthcare Inc
Rosivo Inc
Rottapharm Biotech Srl
Royal College of Surgeons Ireland
Ruilin Biomedical Nanjing Co Ltd
Rutgers The State University of New Jersey
Sanara MedTech Inc
Scil Technology GmbH
SDIP Innovations Pty Ltd
SeaSpine, Inc.
Seikagaku Corp
Serigen Mediproducts Pvt Ltd
Shin Poong Pharm Co Ltd
SIRAKOSS Ltd
Smith & Nephew Inc
Sofregen Medical Inc
Soteira Inc
Sparta Biomedical Inc
SpineGuard SA
SpineOvations Inc
SpineSmith Holdings LLC
Sree Chitra Tirunal Institute for Medical Sciences & Technology
Stanford University
STEL Technologies LLC
Stemmatters Biotecnologia e Medicina Regenerativa SA
SurgaColl Technologies Ltd
Surgalign Holdings Inc
SurGenTec LLC
Symic Bio Inc
T&R Biofab Co Ltd
TBF Genie Tissulaire
Tetratherix Pty Ltd
Texas A&M University
The Chinese University of Hong Kong
The University of Nottingham
Theradaptive Inc
Theragnostic Technologies Inc
TiGenix NV
Tissue Regeneration Systems, Inc.
Tissue Regenix Group PLC
Trinity College Dublin
Universiti Putra Malaysia
University College Dublin
University of Alberta
University of Arizona
University of Auckland
University of Bergen
University of Bielefeld
University of California Davis
University of California Los Angeles
University of California San Diego
University of Connecticut Health Center
University of Edinburgh
University of Florida
University of Georgia
University of Helsinki
University of Iowa
University of Kansas
University of Malaya
University of Maryland
University of Melbourne
University of Memphis
University of Missouri
University of Oulu
University of Pecs
University of Pennsylvania
University of Queensland
University of South Florida
University of Texas at Arlington
University of the Witwatersrand
University of Toledo
University of Utah
University of Wisconsin Madison
University of York
UNSW Medicine
Vanderbilt University
Vericel Corp
Vivex Biologics Inc
Wake Forest University
Wayne State University
Worcester Polytechnic Institute
Wright Medical Group NV
Xtant Medical Holdings Inc
ZetaGen Therapeutics Inc
Zimmer Biomet Holdings Inc

Table of Contents

1 Table of Contents 3

|1.1 List of Tables 18

|1.2 List of Figures 45

2 Introduction 46

2.1 Orthobiologics Overview 46

3 Products under Development 49

3.1 Orthobiologics – Pipeline Products by Stage of Development 49

3.2 Orthobiologics – Pipeline Products by Segment 50

3.3 Orthobiologics – Pipeline Products by Territory 52

3.4 Orthobiologics – Pipeline Products by Regulatory Path 54

3.5 Orthobiologics – Pipeline Products by Estimated Approval Date 55

3.6 Orthobiologics – Ongoing Clinical Trials 56

4 Orthobiologics – Pipeline Products under Development by Companies 57

4.1 Orthobiologics Companies – Pipeline Products by Stage of Development 57

4.2 Orthobiologics – Pipeline Products by Stage of Development 68

5 Orthobiologics Companies and Product Overview 81

5.1 3D Bio Corp Company Overview 81

5.1.1 3D Bio Corp Pipeline Products & Ongoing Clinical Trials Overview 81

5.2 Abyrx, Inc. Company Overview 82

5.2.1 Abyrx, Inc. Pipeline Products & Ongoing Clinical Trials Overview 82

5.3 Acro Biomedical Co Ltd Company Overview 83

5.3.1 Acro Biomedical Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 83

5.4 Acuitive Technologies Inc Company Overview 85

5.4.1 Acuitive Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 85

5.5 Adocia SAS Company Overview 87

5.5.1 Adocia SAS Pipeline Products & Ongoing Clinical Trials Overview 87

5.6 Advanced Biologics LLC Company Overview 90

5.6.1 Advanced Biologics LLC Pipeline Products & Ongoing Clinical Trials Overview 90

5.7 Aeon Astron Corporation Company Overview 91

5.7.1 Aeon Astron Corporation Pipeline Products & Ongoing Clinical Trials Overview 91

5.8 Aesculap Biologics LLC Company Overview 92

5.8.1 Aesculap Biologics LLC Pipeline Products & Ongoing Clinical Trials Overview 92

5.9 Agenta Biotechnologies Inc (Inactive) Company Overview 98

5.9.1 Agenta Biotechnologies Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 98

5.10 Allergan Aesthetics Company Overview 99

5.10.1 Allergan Aesthetics Pipeline Products & Ongoing Clinical Trials Overview 99

5.11 Amend Surgical, Inc. Company Overview 100

5.11.1 Amend Surgical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 100

5.12 Ampio Pharmaceuticals Inc Company Overview 101

5.12.1 Ampio Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 101

5.13 Anika Therapeutics Inc Company Overview 103

5.13.1 Anika Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 103

5.14 Antibe Therapeutics Inc Company Overview 121

5.14.1 Antibe Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 121

5.15 Aperion Biologics Corp Company Overview 123

5.15.1 Aperion Biologics Corp Pipeline Products & Ongoing Clinical Trials Overview 123

5.16 Arthro Kinetics AG Company Overview 126

5.16.1 Arthro Kinetics AG Pipeline Products & Ongoing Clinical Trials Overview 126

5.17 Articulate Biosciences LLC Company Overview 128

5.17.1 Articulate Biosciences LLC Pipeline Products & Ongoing Clinical Trials Overview 128

5.18 Artimplant AB (Inactive) Company Overview 129

5.18.1 Artimplant AB (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 129

5.19 Askel Healthcare Ltd Company Overview 130

5.19.1 Askel Healthcare Ltd Pipeline Products & Ongoing Clinical Trials Overview 130

5.20 Aursos, Inc (Inactive) Company Overview 131

5.20.1 Aursos, Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 131

5.21 Azellon Ltd Company Overview 132

5.21.1 Azellon Ltd Pipeline Products & Ongoing Clinical Trials Overview 132

5.22 B. Braun Melsungen AG Company Overview 133

5.22.1 B. Braun Melsungen AG Pipeline Products & Ongoing Clinical Trials Overview 133

5.23 Baxter International Inc Company Overview 134

5.23.1 Baxter International Inc Pipeline Products & Ongoing Clinical Trials Overview 134

5.24 Ben-Gurion University of the Negev Company Overview 135

5.24.1 Ben-Gurion University of the Negev Pipeline Products & Ongoing Clinical Trials Overview 135

5.25 Berkeley Advanced Biomaterials Inc Company Overview 137

5.25.1 Berkeley Advanced Biomaterials Inc Pipeline Products & Ongoing Clinical Trials Overview 137

5.26 Bio2 Technologies Inc Company Overview 139

5.26.1 Bio2 Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 139

5.27 Bioactive Bone Substitutes Plc Company Overview 142

5.27.1 Bioactive Bone Substitutes Plc Pipeline Products & Ongoing Clinical Trials Overview 142

5.28 BioCure Inc Company Overview 145

5.28.1 BioCure Inc Pipeline Products & Ongoing Clinical Trials Overview 145

5.29 BioGend Therapeutics Co Ltd Company Overview 146

5.29.1 BioGend Therapeutics Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 146

5.30 Biologics 4 Life SAS Company Overview 151

5.30.1 Biologics 4 Life SAS Pipeline Products & Ongoing Clinical Trials Overview 151

5.31 Biomatlante SA Company Overview 153

5.31.1 Biomatlante SA Pipeline Products & Ongoing Clinical Trials Overview 153

5.32 Biomimedica, Inc. Company Overview 156

5.32.1 Biomimedica, Inc. Pipeline Products & Ongoing Clinical Trials Overview 156

5.33 Bionext Biotech Products Ltd. Company Overview 157

5.33.1 Bionext Biotech Products Ltd. Pipeline Products & Ongoing Clinical Trials Overview 157

5.34 Bioregeneration Technologies, Inc Company Overview 158

5.34.1 Bioregeneration Technologies, Inc Pipeline Products & Ongoing Clinical Trials Overview 158

5.35 Biorez Inc Company Overview 159

5.35.1 Biorez Inc Pipeline Products & Ongoing Clinical Trials Overview 159

5.36 Bio-Scaffold International Pte Ltd Company Overview 160

5.36.1 Bio-Scaffold International Pte Ltd Pipeline Products & Ongoing Clinical Trials Overview 160

5.37 Bioventus Inc Company Overview 163

5.37.1 Bioventus Inc Pipeline Products & Ongoing Clinical Trials Overview 163

5.38 BMG Pharma SpA Company Overview 165

5.38.1 BMG Pharma SpA Pipeline Products & Ongoing Clinical Trials Overview 165

5.39 BonAlive Biomaterials Ltd. Company Overview 166

5.39.1 BonAlive Biomaterials Ltd. Pipeline Products & Ongoing Clinical Trials Overview 166

5.40 Bone Biologics Corp Company Overview 167

5.40.1 Bone Biologics Corp Pipeline Products & Ongoing Clinical Trials Overview 167

5.41 Bone Sci. Bio Ltd Company Overview 173

5.41.1 Bone Sci. Bio Ltd Pipeline Products & Ongoing Clinical Trials Overview 173

5.42 Bone Solutions Inc Company Overview 174

5.42.1 Bone Solutions Inc Pipeline Products & Ongoing Clinical Trials Overview 174

5.43 Bone Therapeutics SA Company Overview 177

5.43.1 Bone Therapeutics SA Pipeline Products & Ongoing Clinical Trials Overview 177

5.44 BoneGrafix, Inc. Company Overview 178

5.44.1 BoneGrafix, Inc. Pipeline Products & Ongoing Clinical Trials Overview 178

5.45 BoneSupport AB Company Overview 179

5.45.1 BoneSupport AB Pipeline Products & Ongoing Clinical Trials Overview 179

5.46 Bonus BioGroup Ltd Company Overview 186

5.46.1 Bonus BioGroup Ltd Pipeline Products & Ongoing Clinical Trials Overview 186

5.47 Calcitec, Inc. Company Overview 191

5.47.1 Calcitec, Inc. Pipeline Products & Ongoing Clinical Trials Overview 191

5.48 Carmell Therapeutics Corp Company Overview 192

5.48.1 Carmell Therapeutics Corp Pipeline Products & Ongoing Clinical Trials Overview 192

5.49 Carticept Medical Inc Company Overview 198

5.49.1 Carticept Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 198

5.50 CartiCure Ltd Company Overview 199

5.50.1 CartiCure Ltd Pipeline Products & Ongoing Clinical Trials Overview 199

5.51 Cartilage Inc Company Overview 200

5.51.1 Cartilage Inc Pipeline Products & Ongoing Clinical Trials Overview 200

5.52 Cartiva Inc Company Overview 201

5.52.1 Cartiva Inc Pipeline Products & Ongoing Clinical Trials Overview 201

5.53 Case Western Reserve University Company Overview 204

5.53.1 Case Western Reserve University Pipeline Products & Ongoing Clinical Trials Overview 204

5.54 CellSeed Inc Company Overview 205

5.54.1 CellSeed Inc Pipeline Products & Ongoing Clinical Trials Overview 205

5.55 Cellulosic Biotherapeutics Company Overview 206

5.55.1 Cellulosic Biotherapeutics Pipeline Products & Ongoing Clinical Trials Overview 206

5.56 Cellumed Co Ltd Company Overview 207

5.56.1 Cellumed Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 207

5.57 Center for Biomedical Research Network in Bioengineering, Biomaterials and Nanomedicine Company Overview 209

5.57.1 Center for Biomedical Research Network in Bioengineering, Biomaterials and Nanomedicine Pipeline Products & Ongoing Clinical Trials Overview 209

5.58 CeraPedics Inc Company Overview 210

5.58.1 CeraPedics Inc Pipeline Products & Ongoing Clinical Trials Overview 210

5.59 Chi2Gel Ltd. Company Overview 213

5.59.1 Chi2Gel Ltd. Pipeline Products & Ongoing Clinical Trials Overview 213

5.60 ChitogenX Inc Company Overview 214

5.60.1 ChitogenX Inc Pipeline Products & Ongoing Clinical Trials Overview 214

5.61 Citrics Biomedical, LLC (Inactive) Company Overview 221

5.61.1 Citrics Biomedical, LLC (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 221

5.62 Cleveland Clinic Lerner College of Medicine Company Overview 222

5.62.1 Cleveland Clinic Lerner College of Medicine Pipeline Products & Ongoing Clinical Trials Overview 222

5.63 Cocoon Biotech, Inc. Company Overview 223

5.63.1 Cocoon Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 223

5.64 Collagen Solutions Ltd Company Overview 224

5.64.1 Collagen Solutions Ltd Pipeline Products & Ongoing Clinical Trials Overview 224

5.65 Collplant Biotechnologies Ltd Company Overview 226

5.65.1 Collplant Biotechnologies Ltd Pipeline Products & Ongoing Clinical Trials Overview 226

5.66 Colorado Therapeutics, LLC Company Overview 231

5.66.1 Colorado Therapeutics, LLC Pipeline Products & Ongoing Clinical Trials Overview 231

5.67 Connective Orthopaedics Inc (Inactive) Company Overview 234

5.67.1 Connective Orthopaedics Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 234

5.68 Contura International A/S Company Overview 235

5.68.1 Contura International A/S Pipeline Products & Ongoing Clinical Trials Overview 235

5.69 Core Essence Orthopaedics, LLC Company Overview 238

5.69.1 Core Essence Orthopaedics, LLC Pipeline Products & Ongoing Clinical Trials Overview 238

5.70 CoreSpine Technologies LLC Company Overview 239

5.70.1 CoreSpine Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 239

5.71 Curative Biosciences, Inc. Company Overview 240

5.71.1 Curative Biosciences, Inc. Pipeline Products & Ongoing Clinical Trials Overview 240

5.72 Cyfuse Biomedical KK Company Overview 242

5.72.1 Cyfuse Biomedical KK Pipeline Products & Ongoing Clinical Trials Overview 242

5.73 Daewoong Pharmaceutical Co Ltd Company Overview 243

5.73.1 Daewoong Pharmaceutical Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 243

5.74 Department of Biomedical Engineering Columbia University Company Overview 245

5.74.1 Department of Biomedical Engineering Columbia University Pipeline Products & Ongoing Clinical Trials Overview 245

5.75 DePuy Mitek, LLC Company Overview 247

5.75.1 DePuy Mitek, LLC Pipeline Products & Ongoing Clinical Trials Overview 247

5.76 Dimension Inx LLC Company Overview 248

5.76.1 Dimension Inx LLC Pipeline Products & Ongoing Clinical Trials Overview 248

5.77 DJO Global Inc Company Overview 251

5.77.1 DJO Global Inc Pipeline Products & Ongoing Clinical Trials Overview 251

5.78 Drexel University Company Overview 254

5.78.1 Drexel University Pipeline Products & Ongoing Clinical Trials Overview 254

5.79 DSM Biomedical BV Company Overview 256

5.79.1 DSM Biomedical BV Pipeline Products & Ongoing Clinical Trials Overview 256

5.80 Duke University Company Overview 257

5.80.1 Duke University Pipeline Products & Ongoing Clinical Trials Overview 257

5.81 Eepta Pty Ltd Company Overview 258

5.81.1 Eepta Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 258

5.82 Eindhoven University of Technology Company Overview 259

5.82.1 Eindhoven University of Technology Pipeline Products & Ongoing Clinical Trials Overview 259

5.83 Element Orthopedics Inc (Inactive) Company Overview 261

5.83.1 Element Orthopedics Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 261

5.84 Elute Inc Company Overview 262

5.84.1 Elute Inc Pipeline Products & Ongoing Clinical Trials Overview 262

5.85 ElutInc Company Overview 263

5.85.1 ElutInc Pipeline Products & Ongoing Clinical Trials Overview 263

5.86 Ember Therapeutics Inc Company Overview 265

5.86.1 Ember Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 265

5.87 Embody LLC Company Overview 266

5.87.1 Embody LLC Pipeline Products & Ongoing Clinical Trials Overview 266

5.88 EpiBone Inc Company Overview 268

5.88.1 EpiBone Inc Pipeline Products & Ongoing Clinical Trials Overview 268

5.89 Eskisehir Osmangazi University Company Overview 271

5.89.1 Eskisehir Osmangazi University Pipeline Products & Ongoing Clinical Trials Overview 271

5.90 EternoGen Aesthetics LLC Company Overview 272

5.90.1 EternoGen Aesthetics LLC Pipeline Products & Ongoing Clinical Trials Overview 272

5.91 Evonik Corp Company Overview 273

5.91.1 Evonik Corp Pipeline Products & Ongoing Clinical Trials Overview 273

5.92 Exactech Inc Company Overview 274

5.92.1 Exactech Inc Pipeline Products & Ongoing Clinical Trials Overview 274

5.93 ExceeMatrix (Inactive) Company Overview 275

5.93.1 ExceeMatrix (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 275

5.94 Ferring Pharmaceuticals AS Company Overview 276

5.94.1 Ferring Pharmaceuticals AS Pipeline Products & Ongoing Clinical Trials Overview 276

5.95 Flex Biomedical Inc Company Overview 280

5.95.1 Flex Biomedical Inc Pipeline Products & Ongoing Clinical Trials Overview 280

5.96 Formae, Inc. Company Overview 281

5.96.1 Formae, Inc. Pipeline Products & Ongoing Clinical Trials Overview 281

5.97 Forsagen LLC Company Overview 282

5.97.1 Forsagen LLC Pipeline Products & Ongoing Clinical Trials Overview 282

5.98 Forticell Bioscience Inc Company Overview 283

5.98.1 Forticell Bioscience Inc Pipeline Products & Ongoing Clinical Trials Overview 283

5.99 Fuse Medical Inc Company Overview 284

5.99.1 Fuse Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 284

5.100 Geistlich Pharma AG Company Overview 286

5.100.1 Geistlich Pharma AG Pipeline Products & Ongoing Clinical Trials Overview 286

5.101 Gel-Del Technologies, Inc. Company Overview 287

5.101.1 Gel-Del Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 287

5.102 Gene Biotherapeutics Inc Company Overview 289

5.102.1 Gene Biotherapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 289

5.103 George Washington University Company Overview 290

5.103.1 George Washington University Pipeline Products & Ongoing Clinical Trials Overview 290

5.104 Georgia Institute of Technology Company Overview 291

5.104.1 Georgia Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 291

5.105 Graftoss Limited Company Overview 292

5.105.1 Graftoss Limited Pipeline Products & Ongoing Clinical Trials Overview 292

5.106 Graftys SA Company Overview 293

5.106.1 Graftys SA Pipeline Products & Ongoing Clinical Trials Overview 293

5.107 GreenBone Ortho srl Company Overview 297

5.107.1 GreenBone Ortho srl Pipeline Products & Ongoing Clinical Trials Overview 297

5.108 Gunze Ltd Company Overview 300

5.108.1 Gunze Ltd Pipeline Products & Ongoing Clinical Trials Overview 300

5.109 Hainan Susheng Biological Technology Co Ltd Company Overview 303

5.109.1 Hainan Susheng Biological Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 303

5.110 Hangzhou Huamai Medical Equipment Co Ltd Company Overview 304

5.110.1 Hangzhou Huamai Medical Equipment Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 304

5.111 Harbor MedTech Inc Company Overview 307

5.111.1 Harbor MedTech Inc Pipeline Products & Ongoing Clinical Trials Overview 307

5.112 Herng Shan Co Ltd Company Overview 308

5.112.1 Herng Shan Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 308

5.113 Histogen Inc Company Overview 310

5.113.1 Histogen Inc Pipeline Products & Ongoing Clinical Trials Overview 310

5.114 Hong Kong Polytechnic University Company Overview 312

5.114.1 Hong Kong Polytechnic University Pipeline Products & Ongoing Clinical Trials Overview 312

5.115 Hospital for Special Surgery Company Overview 313

5.115.1 Hospital for Special Surgery Pipeline Products & Ongoing Clinical Trials Overview 313

5.116 Hy2Care BV Company Overview 314

5.116.1 Hy2Care BV Pipeline Products & Ongoing Clinical Trials Overview 314

5.117 Hyalex Orthopaedics Inc Company Overview 317

5.117.1 Hyalex Orthopaedics Inc Pipeline Products & Ongoing Clinical Trials Overview 317

5.118 Hydro-Gen LLC Company Overview 322

5.118.1 Hydro-Gen LLC Pipeline Products & Ongoing Clinical Trials Overview 322

5.119 iFyber LLC Company Overview 323

5.119.1 iFyber LLC Pipeline Products & Ongoing Clinical Trials Overview 323

5.120 Indian Institute of Technology Bombay Company Overview 324

5.120.1 Indian Institute of Technology Bombay Pipeline Products & Ongoing Clinical Trials Overview 324

5.121 Induce Biologics Inc. Company Overview 326

5.121.1 Induce Biologics Inc. Pipeline Products & Ongoing Clinical Trials Overview 326

5.122 Industrie Biomediche Insubri SA Company Overview 327

5.122.1 Industrie Biomediche Insubri SA Pipeline Products & Ongoing Clinical Trials Overview 327

5.123 Inion Oy Company Overview 329

5.123.1 Inion Oy Pipeline Products & Ongoing Clinical Trials Overview 329

5.124 Innovative Elements LLC Company Overview 330

5.124.1 Innovative Elements LLC Pipeline Products & Ongoing Clinical Trials Overview 330

5.125 Innovia LLC Company Overview 331

5.125.1 Innovia LLC Pipeline Products & Ongoing Clinical Trials Overview 331

5.126 Innovoss Inc. (Inactive) Company Overview 332

5.126.1 Innovoss Inc. (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 332

5.127 Intralink-Spine LLC Company Overview 333

5.127.1 Intralink-Spine LLC Pipeline Products & Ongoing Clinical Trials Overview 333

5.128 IRCCS San Raffaele Hospital Company Overview 336

5.128.1 IRCCS San Raffaele Hospital Pipeline Products & Ongoing Clinical Trials Overview 336

5.129 Isto Biologics Company Overview 337

5.129.1 Isto Biologics Pipeline Products & Ongoing Clinical Trials Overview 337

5.130 Johns Hopkins University Company Overview 339

5.130.1 Johns Hopkins University Pipeline Products & Ongoing Clinical Trials Overview 339

5.131 Kalvista Pharmaceuticals Inc Company Overview 342

5.131.1 Kalvista Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 342

5.132 kasios sas Company Overview 345

5.132.1 kasios sas Pipeline Products & Ongoing Clinical Trials Overview 345

5.133 KeraCure, Inc. (Inactive) Company Overview 347

5.133.1 KeraCure, Inc. (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 347

5.134 Keratin Biosciences Inc Company Overview 348

5.134.1 Keratin Biosciences Inc Pipeline Products & Ongoing Clinical Trials Overview 348

5.135 King’s College London Company Overview 349

5.135.1 King’s College London Pipeline Products & Ongoing Clinical Trials Overview 349

5.136 KiOmed Pharma Company Overview 350

5.136.1 KiOmed Pharma Pipeline Products & Ongoing Clinical Trials Overview 350

5.137 Kuros Biosciences AG Company Overview 351

5.137.1 Kuros Biosciences AG Pipeline Products & Ongoing Clinical Trials Overview 351

5.138 Kytogenics Pharmaceuticals Inc Company Overview 355

5.138.1 Kytogenics Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 355

5.139 L&C Bio Company Overview 356

5.139.1 L&C Bio Pipeline Products & Ongoing Clinical Trials Overview 356

5.140 Labrha International Company Overview 359

5.140.1 Labrha International Pipeline Products & Ongoing Clinical Trials Overview 359

5.141 Lamina Therapeutics Company Overview 363

5.141.1 Lamina Therapeutics Pipeline Products & Ongoing Clinical Trials Overview 363

5.142 Lattice Biologics Ltd Company Overview 364

5.142.1 Lattice Biologics Ltd Pipeline Products & Ongoing Clinical Trials Overview 364

5.143 LG Chem Ltd Company Overview 367

5.143.1 LG Chem Ltd Pipeline Products & Ongoing Clinical Trials Overview 367

5.144 Lineage Cell Therapeutics Inc Company Overview 368

5.144.1 Lineage Cell Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 368

5.145 Locate Bio Ltd Company Overview 371

5.145.1 Locate Bio Ltd Pipeline Products & Ongoing Clinical Trials Overview 371

5.146 Luna Innovations Inc Company Overview 374

5.146.1 Luna Innovations Inc Pipeline Products & Ongoing Clinical Trials Overview 374

5.147 Magle Chemoswed AB Company Overview 375

5.147.1 Magle Chemoswed AB Pipeline Products & Ongoing Clinical Trials Overview 375

5.148 Max Biopharma Inc Company Overview 376

5.148.1 Max Biopharma Inc Pipeline Products & Ongoing Clinical Trials Overview 376

5.149 Maxigen Biotech Inc Company Overview 377

5.149.1 Maxigen Biotech Inc Pipeline Products & Ongoing Clinical Trials Overview 377

5.150 Medical Magnesium GmbH Company Overview 379

5.150.1 Medical Magnesium GmbH Pipeline Products & Ongoing Clinical Trials Overview 379

5.151 Medisse BV (Inactive) Company Overview 380

5.151.1 Medisse BV (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 380

5.152 Medshape Inc Company Overview 381

5.152.1 Medshape Inc Pipeline Products & Ongoing Clinical Trials Overview 381

5.153 Medtronic Plc Company Overview 382

5.153.1 Medtronic Plc Pipeline Products & Ongoing Clinical Trials Overview 382

5.154 Medytox Inc Company Overview 389

5.154.1 Medytox Inc Pipeline Products & Ongoing Clinical Trials Overview 389

5.155 MiMedx Group Inc Company Overview 390

5.155.1 MiMedx Group Inc Pipeline Products & Ongoing Clinical Trials Overview 390

5.156 Miromatrix Medical Inc Company Overview 393

5.156.1 Miromatrix Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 393

5.157 Mitogen, Inc. Company Overview 394

5.157.1 Mitogen, Inc. Pipeline Products & Ongoing Clinical Trials Overview 394

5.158 Mochida Pharmaceutical Co Ltd Company Overview 395

5.158.1 Mochida Pharmaceutical Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 395

5.159 Moebius Medical Ltd Company Overview 396

5.159.1 Moebius Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview 396

5.160 N2 Biomedical Company Overview 399

5.160.1 N2 Biomedical Pipeline Products & Ongoing Clinical Trials Overview 399

5.161 Nanochon LLC Company Overview 400

5.161.1 Nanochon LLC Pipeline Products & Ongoing Clinical Trials Overview 400

5.162 National Center of Innovation for Biomaterials in Orthopaedic Research Company Overview 401

5.162.1 National Center of Innovation for Biomaterials in Orthopaedic Research Pipeline Products & Ongoing Clinical Trials Overview 401

5.163 National University of Science and Technology MiSiS Company Overview 402

5.163.1 National University of Science and Technology MiSiS Pipeline Products & Ongoing Clinical Trials Overview 402

5.164 NC Biomatrix BV Company Overview 403

5.164.1 NC Biomatrix BV Pipeline Products & Ongoing Clinical Trials Overview 403

5.165 NDSU Research Foundation Company Overview 404

5.165.1 NDSU Research Foundation Pipeline Products & Ongoing Clinical Trials Overview 404

5.166 New York R&D Center for Translational Medicine and Therapeutics Inc Company Overview 405

5.166.1 New York R&D Center for Translational Medicine and Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 405

5.167 New York University Company Overview 406

5.167.1 New York University Pipeline Products & Ongoing Clinical Trials Overview 406

5.168 Nexxt Spine LLC Company Overview 408

5.168.1 Nexxt Spine LLC Pipeline Products & Ongoing Clinical Trials Overview 408

5.169 Novadip Biosciences SA Company Overview 409

5.169.1 Novadip Biosciences SA Pipeline Products & Ongoing Clinical Trials Overview 409

5.170 Novaicos Srls Company Overview 412

5.170.1 Novaicos Srls Pipeline Products & Ongoing Clinical Trials Overview 412

5.171 Novatex Bioengineering SA Company Overview 415

5.171.1 Novatex Bioengineering SA Pipeline Products & Ongoing Clinical Trials Overview 415

5.172 Novatissue SAS Company Overview 416

5.172.1 Novatissue SAS Pipeline Products & Ongoing Clinical Trials Overview 416

5.173 NuShores Biosciences LLC Company Overview 417

5.173.1 NuShores Biosciences LLC Pipeline Products & Ongoing Clinical Trials Overview 417

5.174 Nutech Medical Inc Company Overview 418

5.174.1 Nutech Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 418

5.175 NuVasive Inc Company Overview 422

5.175.1 NuVasive Inc Pipeline Products & Ongoing Clinical Trials Overview 422

5.176 Ocugen Inc Company Overview 423

5.176.1 Ocugen Inc Pipeline Products & Ongoing Clinical Trials Overview 423

5.177 OHSU Knight Cancer Institute Company Overview 425

5.177.1 OHSU Knight Cancer Institute Pipeline Products & Ongoing Clinical Trials Overview 425

5.178 Oklahoma State University Company Overview 426

5.178.1 Oklahoma State University Pipeline Products & Ongoing Clinical Trials Overview 426

5.179 Oligo Medic Inc Company Overview 428

5.179.1 Oligo Medic Inc Pipeline Products & Ongoing Clinical Trials Overview 428

5.180 Olympus RMS Co Ltd Company Overview 433

5.180.1 Olympus RMS Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 433

5.181 OPKO Health Inc Company Overview 434

5.181.1 OPKO Health Inc Pipeline Products & Ongoing Clinical Trials Overview 434

5.182 Orchestra BioMed Inc Company Overview 435

5.182.1 Orchestra BioMed Inc Pipeline Products & Ongoing Clinical Trials Overview 435

5.183 Orteq Sports Medicine Ltd Company Overview 436

5.183.1 Orteq Sports Medicine Ltd Pipeline Products & Ongoing Clinical Trials Overview 436

5.184 Ortheon Medical, LLC. Company Overview 437

5.184.1 Ortheon Medical, LLC. Pipeline Products & Ongoing Clinical Trials Overview 437

5.185 Orthocell Ltd Company Overview 438

5.185.1 Orthocell Ltd Pipeline Products & Ongoing Clinical Trials Overview 438

5.186 Orthofix Medical Inc Company Overview 444

5.186.1 Orthofix Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 444

5.187 OrthoMedex LLC Company Overview 450

5.187.1 OrthoMedex LLC Pipeline Products & Ongoing Clinical Trials Overview 450

5.188 OrthoMend Research Inc Company Overview 451

5.188.1 OrthoMend Research Inc Pipeline Products & Ongoing Clinical Trials Overview 451

5.189 Orthosera GmbH Company Overview 452

5.189.1 Orthosera GmbH Pipeline Products & Ongoing Clinical Trials Overview 452

5.190 Orthox Ltd Company Overview 453

5.190.1 Orthox Ltd Pipeline Products & Ongoing Clinical Trials Overview 453

5.191 OssiFi Inc Company Overview 459

5.191.1 OssiFi Inc Pipeline Products & Ongoing Clinical Trials Overview 459

5.192 OsteoGenix Incorporated (Inactive) Company Overview 460

5.192.1 OsteoGenix Incorporated (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 460

5.193 OsteoNovus, LLC Company Overview 461

5.193.1 OsteoNovus, LLC Pipeline Products & Ongoing Clinical Trials Overview 461

5.194 Osteopore International Pte Ltd Company Overview 462

5.194.1 Osteopore International Pte Ltd Pipeline Products & Ongoing Clinical Trials Overview 462

5.195 Paras Biopharmaceuticals Finland Oy Company Overview 464

5.195.1 Paras Biopharmaceuticals Finland Oy Pipeline Products & Ongoing Clinical Trials Overview 464

5.196 Particle3D Company Overview 465

5.196.1 Particle3D Pipeline Products & Ongoing Clinical Trials Overview 465

5.197 PBC Biomed Ltd Company Overview 467

5.197.1 PBC Biomed Ltd Pipeline Products & Ongoing Clinical Trials Overview 467

5.198 Piramal Enterprises Ltd Company Overview 468

5.198.1 Piramal Enterprises Ltd Pipeline Products & Ongoing Clinical Trials Overview 468

5.199 PolarityTE Inc Company Overview 470

5.199.1 PolarityTE Inc Pipeline Products & Ongoing Clinical Trials Overview 470

5.200 PolyNovo Biomaterials Pty Ltd Company Overview 471

5.200.1 PolyNovo Biomaterials Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 471

5.201 PolyPid Ltd Company Overview 472

5.201.1 PolyPid Ltd Pipeline Products & Ongoing Clinical Trials Overview 472

5.202 Polytechnic University of Catalonia Company Overview 473

5.202.1 Polytechnic University of Catalonia Pipeline Products & Ongoing Clinical Trials Overview 473

5.203 Progenteq Company Overview 475

5.203.1 Progenteq Pipeline Products & Ongoing Clinical Trials Overview 475

5.204 Prohibix LLC Company Overview 476

5.204.1 Prohibix LLC Pipeline Products & Ongoing Clinical Trials Overview 476

5.205 Promedon SA Company Overview 477

5.205.1 Promedon SA Pipeline Products & Ongoing Clinical Trials Overview 477

5.206 Promimic AB Company Overview 480

5.206.1 Promimic AB Pipeline Products & Ongoing Clinical Trials Overview 480

5.207 ReCaPP Company Overview 481

5.207.1 ReCaPP Pipeline Products & Ongoing Clinical Trials Overview 481

5.208 REGENECURE Ltd Company Overview 482

5.208.1 REGENECURE Ltd Pipeline Products & Ongoing Clinical Trials Overview 482

5.209 Regentis Biomaterials Ltd Company Overview 483

5.209.1 Regentis Biomaterials Ltd Pipeline Products & Ongoing Clinical Trials Overview 483

5.210 Renovos Biologics Ltd Company Overview 488

5.210.1 Renovos Biologics Ltd Pipeline Products & Ongoing Clinical Trials Overview 488

5.211 RepRegen Ltd. (Inactive) Company Overview 489

5.211.1 RepRegen Ltd. (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 489

5.212 Resultados y Calidad del Sistema Sanitario Publico de Andalucia Company Overview 491

5.212.1 Resultados y Calidad del Sistema Sanitario Publico de Andalucia Pipeline Products & Ongoing Clinical Trials Overview 491

5.213 Revivicor Inc Company Overview 492

5.213.1 Revivicor Inc Pipeline Products & Ongoing Clinical Trials Overview 492

5.214 Richard L. Roudebush VAMC Company Overview 493

5.214.1 Richard L. Roudebush VAMC Pipeline Products & Ongoing Clinical Trials Overview 493

5.215 ROKIT Healthcare Inc Company Overview 494

5.215.1 ROKIT Healthcare Inc Pipeline Products & Ongoing Clinical Trials Overview 494

5.216 Rosivo Inc Company Overview 497

5.216.1 Rosivo Inc Pipeline Products & Ongoing Clinical Trials Overview 497

5.217 Rottapharm Biotech Srl Company Overview 499

5.217.1 Rottapharm Biotech Srl Pipeline Products & Ongoing Clinical Trials Overview 499

5.218 Royal College of Surgeons Ireland Company Overview 500

5.218.1 Royal College of Surgeons Ireland Pipeline Products & Ongoing Clinical Trials Overview 500

5.219 Ruilin Biomedical Nanjing Co Ltd Company Overview 502

5.219.1 Ruilin Biomedical Nanjing Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 502

5.220 Rutgers The State University of New Jersey Company Overview 505

5.220.1 Rutgers The State University of New Jersey Pipeline Products & Ongoing Clinical Trials Overview 505

5.221 Sanara MedTech Inc Company Overview 506

5.221.1 Sanara MedTech Inc Pipeline Products & Ongoing Clinical Trials Overview 506

5.222 Scil Technology GmbH Company Overview 507

5.222.1 Scil Technology GmbH Pipeline Products & Ongoing Clinical Trials Overview 507

5.223 SDIP Innovations Pty Ltd Company Overview 510

5.223.1 SDIP Innovations Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 510

5.224 SeaSpine, Inc. Company Overview 511

5.224.1 SeaSpine, Inc. Pipeline Products & Ongoing Clinical Trials Overview 511

5.225 Seikagaku Corp Company Overview 512

5.225.1 Seikagaku Corp Pipeline Products & Ongoing Clinical Trials Overview 512

5.226 Serigen Mediproducts Pvt Ltd Company Overview 514

5.226.1 Serigen Mediproducts Pvt Ltd Pipeline Products & Ongoing Clinical Trials Overview 514

5.227 Shin Poong Pharm Co Ltd Company Overview 515

5.227.1 Shin Poong Pharm Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 515

5.228 SIRAKOSS Ltd Company Overview 516

5.228.1 SIRAKOSS Ltd Pipeline Products & Ongoing Clinical Trials Overview 516

5.229 Smith & Nephew Inc Company Overview 519

5.229.1 Smith & Nephew Inc Pipeline Products & Ongoing Clinical Trials Overview 519

5.230 Sofregen Medical Inc Company Overview 520

5.230.1 Sofregen Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 520

5.231 Soteira Inc Company Overview 522

5.231.1 Soteira Inc Pipeline Products & Ongoing Clinical Trials Overview 522

5.232 Sparta Biomedical Inc Company Overview 523

5.232.1 Sparta Biomedical Inc Pipeline Products & Ongoing Clinical Trials Overview 523

5.233 SpineGuard SA Company Overview 524

5.233.1 SpineGuard SA Pipeline Products & Ongoing Clinical Trials Overview 524

5.234 SpineOvations Inc Company Overview 525

5.234.1 SpineOvations Inc Pipeline Products & Ongoing Clinical Trials Overview 525

5.235 SpineSmith Holdings LLC Company Overview 526

5.235.1 SpineSmith Holdings LLC Pipeline Products & Ongoing Clinical Trials Overview 526

5.236 Sree Chitra Tirunal Institute for Medical Sciences & Technology Company Overview 528

5.236.1 Sree Chitra Tirunal Institute for Medical Sciences & Technology Pipeline Products & Ongoing Clinical Tria

Table

Orthobiologics – Pipeline Products by Stage of Development 49

Orthobiologics – Pipeline Products by Segment 50

Orthobiologics – Pipeline Products by Territory 52

Orthobiologics – Pipeline Products by Regulatory Path 54

Orthobiologics – Pipeline Products by Estimated Approval Date 55

Orthobiologics – Ongoing Clinical Trials 56

Orthobiologics Companies – Pipeline Products by Stage of Development 57

Orthobiologics – Pipeline Products by Stage of Development 68

3D Bio Corp Pipeline Products & Ongoing Clinical Trials Overview 81

3D Printed Implant – Damaged Meniscus – Product Status 81

3D Printed Implant – Damaged Meniscus – Product Description 81

Abyrx, Inc. Pipeline Products & Ongoing Clinical Trials Overview 82

Osteoinductive Settable Bone Putty – Product Status 82

Osteoinductive Settable Bone Putty – Product Description 82

Acro Biomedical Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 83

Acrobone – Product Status 83

Acrobone – Product Description 83

ACROCHONDRO – Product Status 84

ACROCHONDRO – Product Description 84

Acuitive Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 85

Citrecuff – Product Status 85

Citrecuff – Product Description 85

Citrefoam – Product Status 86

Citrefoam – Product Description 86

Adocia SAS Pipeline Products & Ongoing Clinical Trials Overview 87

BioChaperone BMP – Degenerative Disc Disease – Product Status 87

BioChaperone BMP – Degenerative Disc Disease – Product Description 87

Biochaperone BMP – Non-Union Fractures – Product Status 88

Biochaperone BMP – Non-Union Fractures – Product Description 88

BioChaperone BMP – Osteoporosis – Product Status 88

BioChaperone BMP – Osteoporosis – Product Description 89

Advanced Biologics LLC Pipeline Products & Ongoing Clinical Trials Overview 90

OsteoMEM Shape Memory Scaffold – Product Status 90

OsteoMEM Shape Memory Scaffold – Product Description 90

Aeon Astron Corporation Pipeline Products & Ongoing Clinical Trials Overview 91

BioBone Filler – Product Status 91

BioBone Filler – Product Description 91

Aesculap Biologics LLC Pipeline Products & Ongoing Clinical Trials Overview 92

Novocart – Ankle – Product Status 92

Novocart – Ankle – Product Description 92

Novocart – Hip – Product Status 93

Novocart – Hip – Product Description 93

Novocart 3D – Product Status 93

Novocart 3D – Product Description 94

Novocart 3D Plus – Product Status 94

Novocart 3D Plus – Product Description 94

NOVOCART DISC basic – Product Status 95

NOVOCART DISC basic – Product Description 95

Aesculap Biologics LLC – Ongoing Clinical Trials Overview 96

Novocart 3D – Safety and Efficacy of NOVOCART 3D in the Treatment of Articular Cartilage Defects Following Failure on Microfracture 97

Agenta Biotechnologies Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 98

B-247 Cranial Bone Graft Implant – Product Status 98

B-247 Cranial Bone Graft Implant – Product Description 98

Allergan Aesthetics Pipeline Products & Ongoing Clinical Trials Overview 99

SeriGel – Product Status 99

SeriGel – Product Description 99

Amend Surgical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 100

Biomimetic Bone – Product Status 100

Biomimetic Bone – Product Description 100

Ampio Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 101

Ampion – Product Status 101

Ampion – Product Description 101

Ampion – Hand Osteoarthritis – Product Status 102

Ampion – Hand Osteoarthritis – Product Description 102

Anika Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 103

Cingal – Product Status 104

Cingal – Product Description 104

HA Based Orthobiologic – ACL – Product Status 104

HA Based Orthobiologic – ACL – Product Description 105

HA Based Orthobiologic – Ankle – Product Status 105

HA Based Orthobiologic – Ankle – Product Description 105

HA Based Orthobiologic – Bicep Repair – Product Status 106

HA Based Orthobiologic – Bicep Repair – Product Description 106

HA Based Orthobiologic – Capsule Repair – Product Status 106

HA Based Orthobiologic – Capsule Repair – Product Description 107

HA Based Orthobiologic – CMC – Product Status 107

HA Based Orthobiologic – CMC – Product Description 107

HA Based Orthobiologic – Enthesis Repair – Product Status 108

HA Based Orthobiologic – Enthesis Repair – Product Description 108

HA Based Orthobiologic – Hand/Foot – Product Status 108

HA Based Orthobiologic – Hand/Foot – Product Description 109

HA Based Orthobiologic – Labrum Repair – Product Status 109

HA Based Orthobiologic – Labrum Repair – Product Description 109

HA Based Orthobiologic – Meniscus – Product Status 110

HA Based Orthobiologic – Meniscus – Product Description 110

HA Based Orthobiologic – Superior Capsule Reconstruction – Product Status 110

HA Based Orthobiologic – Superior Capsule Reconstruction – Product Description 111

HA Based Orthobiologic – Tendons/Ligaments – Product Status 111

HA Based Orthobiologic – Tendons/Ligaments – Product Description 111

HA Based Orthobiologic – Wrist – Product Status 112

HA Based Orthobiologic – Wrist – Product Description 112

HYAFF – Rotator Cuff Repair – Product Status 112

HYAFF – Rotator Cuff Repair – Product Description 113

Hyalobone – Product Status 113

Hyalobone – Product Description 113

Hyalofast – Product Status 114

Hyalofast – Product Description 114

Hyalograft C Autograft – Product Status 114

Hyalograft C Autograft – Product Description 115

Hyaluronic Acid – Synovial Joints – Product Status 115

Hyaluronic Acid – Synovial Joints – Product Description 115

MONOVISC – Hip – Product Status 116

MONOVISC – Hip – Product Description 116

ORTHOVISC-T – Product Status 116

ORTHOVISC-T – Product Description 117

Sodium Hyaluronate – Osteoarthritis – Product Status 117

Sodium Hyaluronate – Osteoarthritis – Product Description 117

Anika Therapeutics Inc – Ongoing Clinical Trials Overview 118

Hyalofast – A Prospective, Randomized, Active Treatment-controlled, Evaluator-blinded Multicenter Study to Establish the Superiority of Hyalofast with BMAC in the Treatment of Articular Knee Cartilage Defect Lesions in Comparison to Control 119

Hyalofast – A Study on the Safety and Effectiveness of Improved Microfracture Techniques Using Temperature Sensitive Polymer Hydrogel for Femoral and Cartilage Defects– Prospective, Randomize, Single–center 119

Hyalofast – Cartilage Repair Using a Hyaluronic Acid-based Scaffold with Bone Marrow Aspirate Compared with Microfracture for Focal Articular Cartilage Damage of the Hip: A Randomized Controlled Trial 119

Cingal – A Prospective Evaluation of the Cingal Injection for Hip Osteoarthritis (ECHO Study) 120

Antibe Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 121

CGX-227 – Product Status 121

CGX-227 – Product Description 121

CGX-443 – Product Status 122

CGX-443 – Product Description 122

Aperion Biologics Corp Pipeline Products & Ongoing Clinical Trials Overview 123

Z-Fix – Product Status 123

Z-Fix – Product Description 123

Z-Meniscus – Product Status 124

Z-Meniscus – Product Description 124

Z-Patch – Product Status 124

Z-Patch – Product Description 125

Arthro Kinetics AG Pipeline Products & Ongoing Clinical Trials Overview 126

CaReS plus – Product Status 126

CaReS plus – Product Description 126

Cartiplug – Product Status 127

Cartiplug – Product Description 127

Articulate Biosciences LLC Pipeline Products & Ongoing Clinical Trials Overview 128

Injectable Lubricant – Osteoarthritis – Product Status 128

Injectable Lubricant – Osteoarthritis – Product Description 128

Artimplant AB (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 129

Artelon Scaffold – Cartilage Repair – Product Status 129

Artelon Scaffold – Cartilage Repair – Product Description 129

Askel Healthcare Ltd Pipeline Products & Ongoing Clinical Trials Overview 130

COPLA Scaffold – Product Status 130

COPLA Scaffold – Product Description 130

Aursos, Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 131

AUR-84 Resorbable Implant – Product Status 131

AUR-84 Resorbable Implant – Product Description 131

Azellon Ltd Pipeline Products & Ongoing Clinical Trials Overview 132

Cell Bandage – Product Status 132

Cell Bandage – Product Description 132

B. Braun Melsungen AG Pipeline Products & Ongoing Clinical Trials Overview 133

Biological Knee Regeneration Device – Product Status 133

Biological Knee Regeneration Device – Product Description 133

Baxter International Inc Pipeline Products & Ongoing Clinical Trials Overview 134

Synthetic Bone Graft – Spinal – Product Status 134

Synthetic Bone Graft – Spinal – Product Description 134

Ben-Gurion University of the Negev Pipeline Products & Ongoing Clinical Trials Overview 135

3D Hydrogel – Product Status 135

3D Hydrogel – Product Description 135

Hydrogel Based Injectable Bilayer Device – Product Status 136

Hydrogel Based Injectable Bilayer Device – Product Description 136

Berkeley Advanced Biomaterials Inc Pipeline Products & Ongoing Clinical Trials Overview 137

CPA Ceramics – Product Status 137

CPA Ceramics – Product Description 137

HAP Ceramics – Product Status 138

HAP Ceramics – Product Description 138

Bio2 Technologies Inc Pipeline Products & Ongoing Clinical Trials Overview 139

Vitrium – Hammertoe Correction – Product Status 139

Vitrium – Hammertoe Correction – Product Description 139

Vitrium – Radial Osteotomy – Product Status 140

Vitrium – Radial Osteotomy – Product Description 140

Vitrium – Wrist Fracture Revision – Product Status 140

Vitrium – Wrist Fracture Revision – Product Description 141

Bioactive Bone Substitutes Plc Pipeline Products & Ongoing Clinical Trials Overview 142

Artebone – Product Status 142

Artebone – Product Description 143

Bone Graft Substitute – Blocks – Product Status 143

Bone Graft Substitute – Blocks – Product Description 143

Bone Graft Substitute – Granules – Product Status 144

Bone Graft Substitute – Granules – Product Description 144

BioCure Inc Pipeline Products & Ongoing Clinical Trials Overview 145

BCNP – Product Status 145

BCNP – Product Description 145

BioGend Therapeutics Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 146

OIF – Non-Union Bone Fracture – Product Status 146

OIF – Non-Union Bone Fracture – Product Description 146

OIF/ß-TCP – Block Form – Product Status 147

OIF/ß-TCP – Block Form – Product Description 147

OIF/ß-TCP – Granular Form – Product Status 147

OIF/ß-TCP – Granular Form – Product Description 148

RevoCart – Product Status 148

RevoCart – Product Description 148

BioGend Therapeutics Co Ltd – Ongoing Clinical Trials Overview 149

OIF/ß-TCP – Granular Form – A Randomized, Evaluator-blinded, Controlled Study to Evaluate the Safety and Clinical Performance of OIF/ß-TCP in Patients with Open Tibial Fractures in Need of Bone Grafting 150

Biologics 4 Life SAS Pipeline Products & Ongoing Clinical Trials Overview 151

Implantable Cement – Cancer Metastasis – Product Status 151

Implantable Cement – Cancer Metastasis – Product Description 151

Implantable Cement – Osteoarthritis – Product Status 152

Implantable Cement – Osteoarthritis – Product Description 152

Biomatlante SA Pipeline Products & Ongoing Clinical Trials Overview 153

Biological Graft – Product Status 153

Biological Graft – Product Description 153

Gene-Activated Matrix – Product Status 154

Gene-Activated Matrix – Product Description 154

Hydrogel – Product Status 154

Hydrogel – Product Description 155

Osteoconductive Resorbable Composite – Product Status 155

Osteoconductive Resorbable Composite – Product Description 155

Biomimedica, Inc. Pipeline Products & Ongoing Clinical Trials Overview 156

GRADION Hip Total Cartilage Replacement (TCR) Device – Product Status 156

GRADION Hip Total Cartilage Replacement (TCR) Device – Product Description 156

Bionext Biotech Products Ltd. Pipeline Products & Ongoing Clinical Trials Overview 157

Orthonext – Product Status 157

Orthonext – Product Description 157

Bioregeneration Technologies, Inc Pipeline Products & Ongoing Clinical Trials Overview 158

InMotion – Product Status 158

InMotion – Product Description 158

Biorez Inc Pipeline Products & Ongoing Clinical Trials Overview 159

L-C Ligament – Product Status 159

L-C Ligament – Product Description 159

Bio-Scaffold International Pte Ltd Pipeline Products & Ongoing Clinical Trials Overview 160

BMP And Growth Factor Loaded Scaffold – Orthodontic Oral/Maxillofacial Surgery – Product Status 160

BMP And Growth Factor Loaded Scaffold – Orthodontic Oral/Maxillofacial Surgery – Product Description 160

BMP And Growth Factor Loaded Scaffold – Orthopaedic Surgery – Product Status 161

BMP And Growth Factor Loaded Scaffold – Orthopaedic Surgery – Product Description 161

BMP And Growth Factor Loaded Scaffold – Plastic/Reconstructive Surgery – Product Status 161

BMP And Growth Factor Loaded Scaffold – Plastic/Reconstructive Surgery – Product Description 162

Bioventus Inc Pipeline Products & Ongoing Clinical Trials Overview 163

Bone Allograft – Spine And Trauma Surgery – Product Status 163

Bone Allograft – Spine And Trauma Surgery – Product Description 163

MOTYS – Product Status 164

MOTYS – Product Description 164

BMG Pharma SpA Pipeline Products & Ongoing Clinical Trials Overview 165

SGA400 – Product Status 165

SGA400 – Product Description 165

BonAlive Biomaterials Ltd. Pipeline Products & Ongoing Clinical Trials Overview 166

S53P4 BonAlive Granules – Product Status 166

S53P4 BonAlive Granules – Product Description 166

Bone Biologics Corp Pipeline Products & Ongoing Clinical Trials Overview 167

NELL-1/DBX Fusion Device – Product Status 167

NELL-1/DBX Fusion Device – Product Description 168

NELL-1/DBX Fusion Device – Osteoporosis – Product Status 168

NELL-1/DBX Fusion Device – Osteoporosis – Product Description 168

NELL-1/DBX Fusion Device – Trauma – Product Status 169

NELL-1/DBX Fusion Device – Trauma – Product Description 169

UCS-1 – Product Status 169

UCS-1 – Product Description 170

Bone Biologics Corp – Ongoing Clinical Trials Overview 171

NELL-1/DBX Fusion Device – A Multi-center, Prospective, Parallel Group, Randomized, Pilot Study Evaluating Safety and Preliminary Effectiveness of NB1 Bone Graft in Subjects with Degenerative Disc Disease Undergoing Transforaminal Lumbar Interbody Fusion 172

Bone Sci. Bio Ltd Pipeline Products & Ongoing Clinical Trials Overview 173

PeptOss – Product Status 173

PeptOss – Product Description 173

Bone Solutions Inc Pipeline Products & Ongoing Clinical Trials Overview 174

Osteocrete – Bone Anchor – Product Status 174

Osteocrete – Bone Anchor – Product Description 174

OsteoCrete – Cranial – Product Status 175

OsteoCrete – Cranial – Product Description 175

OsteoCrete – Maxillofacial – Product Status 175

OsteoCrete – Maxillofacial – Product Description 176

OsteoCrete – Non Load Bearing Spine – Product Status 176

OsteoCrete – Non Load Bearing Spine – Product Description 176

Bone Therapeutics SA Pipeline Products & Ongoing Clinical Trials Overview 177

JTA-004 – Product Status 177

JTA-004 – Product Description 177

BoneGrafix, Inc. Pipeline Products & Ongoing Clinical Trials Overview 178

Solid Bone Block – Product Status 178

Solid Bone Block – Product Description 178

BoneSupport AB Pipeline Products & Ongoing Clinical Trials Overview 179

Cerament + Bisphosphonate – Product Status 179

Cerament + Bisphosphonate – Product Description 179

Cerament + Bisphosphonates And BMP – Product Status 180

Cerament + Bisphosphonates And BMP – Product Description 180

Cerament + BMP – Product Status 180

Cerament + BMP – Product Description 181

Cerament + BMP 2 – Product Status 181

Cerament + BMP 2 – Product Description 181

Cerament Plus BMP And Stem Cells – Product Status 182

Cerament Plus BMP And Stem Cells – Product Description 182

Cerament|G – Product Status 182

Cerament|G – Product Description 183

Gelatin/Cerament – Product Status 183

Gelatin/Cerament – Product Description 183

BoneSupport AB – Ongoing Clinical Trials Overview 184

Cerament|G – Evaluation of the Efficiency of the Bone Substitute Cerament-G Locally Delivering Gentamicin in the Treatment of Chronic Osteomyelitis of Long Bones: Randomized Multicentre Study in the CRIOAc Network – CONVICTION Study 185

Cerament|G – Two-stage Treatment of Large Bone Defects with Cerament G and Cerament V plus Auto and/or Allograft Using the Masquelet Technique as Salvage Therapy after Bone Resection in Patients with Septic Pseudarthrosis 185

Bonus BioGroup Ltd Pipeline Products & Ongoing Clinical Trials Overview 186

BonoFill – Maxillofacial Application – Product Status 186

BonoFill – Maxillofacial Application – Product Description 186

BonoFill – Orthopedic Application – Product Status 187

BonoFill – Orthopedic Application – Product Description 187

Combined Bone And Cartilage Graft – Product Status 187

Combined Bone And Cartilage Graft – Product Description 187

Large Vascularized Bone Graft – Product Status 188

Large Vascularized Bone Graft – Product Description 188

Bonus BioGroup Ltd – Ongoing Clinical Trials Overview 189

BonoFill – Maxillofacial Application – Phase I/II Open Label First in Human Single Center Clinical Study Aimed to Evaluate the Safety and Efficacy of BonoFill-II in Reconstructing Maxillofacial Bone 190

Calcitec, Inc. Pipeline Products & Ongoing Clinical Trials Overview 191

Corticell – Product Status 191

Corticell – Product Description 191

Carmell Therapeutics Corp Pipeline Products & Ongoing Clinical Trials Overview 192

Bone Healing Accelerant – DBM Spine – Product Status 192

Bone Healing Accelerant – DBM Spine – Product Description 192

Bone Healing Accelerant – Long Bone (Tibia) Fractures – Product Status 193

Bone Healing Accelerant – Long Bone (Tibia) Fractures – Product Description 193

Bone Healing Accelerant – Shoulder Repair – Product Status 193

Bone Healing Accelerant – Shoulder Repair – Product Description 194

Bone Healing Accelerant – Total Joint Replacement – Product Status 194

Bone Healing Accelerant – Total Joint Replacement – Product Description 194

REPAIR Surgical Scaffold – Product Status 195

REPAIR Surgical Scaffold – Product Description 195

Carmell Therapeutics Corp – Ongoing Clinical Trials Overview 196

Bone Healing Accelerant – Long Bone (Tibia) Fractures – A Multiregion, Randomized, Controlled, Blinded Study of the Safety and Efficacy of Bone Healing Accelerant Versus Standard of Care in Subjects with Open Tibia Fractures 197

Carticept Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 198

Agilus – Product Status 198

Agilus – Product Description 198

CartiCure Ltd Pipeline Products & Ongoing Clinical Trials Overview 199

Cartimove – Product Status 199

Cartimove – Product Description 199

Cartilage Inc Pipeline Products & Ongoing Clinical Trials Overview 200

Hyaleon – Product Status 200

Hyaleon – Product Description 200

Cartiva Inc Pipeline Products & Ongoing Clinical Trials Overview 201

Cartiva Synthetic Cartilage Implant – CMC – Product Status 201

Cartiva Synthetic Cartilage Implant – CMC – Product Description 201

Cartiva Inc – Ongoing Clinical Trials Overview 202

Cartiva Synthetic Cartilage Implant – CMC – A Prospective Study to Evaluate the Safety and Effectiveness of the Cartiva Synthetic Cartilage Implant for CMC in the Treatment of First Carpometacarpal Joint Osteoarthritis as Compared to LRTI Comparator 203

Case Western Reserve University Pipeline Products & Ongoing Clinical Trials Overview 204

Articular Cartilage – Joint Repairs – Product Status 204

Articular Cartilage – Joint Repairs – Product Description 204

CellSeed Inc Pipeline Products & Ongoing Clinical Trials Overview 205

Regenerated Cartilage Sheet – Product Status 205

Regenerated Cartilage Sheet – Product Description 205

Cellulosic Biotherapeutics Pipeline Products & Ongoing Clinical Trials Overview 206

CelluloDisc – Product Status 206

CelluloDisc – Product Description 206

Cellumed Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 207

Porcine Xenograft – Product Status 207

Porcine Xenograft – Product Description 207

Porous PVA Cartilage Graft – Product Status 208

Porous PVA Cartilage Graft – Product Description 208

Center for Biomedical Research Network in Bioengineering, Biomaterials and Nanomedicine Pipeline Products & Ongoing Clinical Trials Overview 209

Bioactive Glass Scaffold – Product Status 209

Bioactive Glass Scaffold – Product Description 209

CeraPedics Inc Pipeline Products & Ongoing Clinical Trials Overview 210

i-FACTOR+ Matrix Peptide Enhanced Bone Graft – Product Status 210

i-FACTOR+ Matrix Peptide Enhanced Bone Graft – Product Description 210

CeraPedics Inc – Ongoing Clinical Trials Overview 211

i-FACTOR+ Matrix Peptide Enhanced Bone Graft – An Assessment of P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion with Instrumentation 212

i-FACTOR+ Matrix Peptide Enhanced Bone Graft – Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device – A Canadian, Multicenter, Post-Market Clinical Investigation 212

Chi2Gel Ltd. Pipeline Products & Ongoing Clinical Trials Overview 213

Chi2Knee – Product Status 213

Chi2Knee – Product Description 213

ChitogenX Inc Pipeline Products & Ongoing Clinical Trials Overview 214

Achilles Tendon Repair Device – Product Status 214

Achilles Tendon Repair Device – Product Description 214

Anterior Cruciate Ligament Repair Device – Product Status 215

Anterior Cruciate Ligament Repair Device – Product Description 215

Ortho-C – Product Status 215

Ortho-C – Product Description 216

Ortho-M – Product Status 216

Ortho-M – Product Description 216

Ortho-R – Product Status 217

Ortho-R – Product Description 217

Ortho-V – Product Status 217

Ortho-V – Product Description 218

Tennis Elbow Repair Device – Product Status 218

Tennis Elbow Repair Device – Product Description 218

ChitogenX Inc – Ongoing Clinical Trials Overview 219

Ortho-R – A Blinded, Randomized Controlled Study Investigating the Safety of Ortho-R for Rotator Cuff Repair Compared with Standard of Care 220

Citrics Biomedical, LLC (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 221

CitrOSponge – Product Status 221

CitrOSponge – Product Description 221

Cleveland Clinic Lerner College of Medicine Pipeline Products & Ongoing Clinical Trials Overview 222

Fascia Extracellular Matrix – Rotator Cuff Repair – Product Status 222

Fascia Extracellular Matrix – Rotator Cuff Repair – Product Description 222

Cocoon Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 223

Silk Hydrogel – Product Status 223

Silk Hydrogel – Product Description 223

Collagen Solutions Ltd Pipeline Products & Ongoing Clinical Trials Overview 224

Bone Graft Substitutes – Product Status 224

Bone Graft Substitutes – Product Description 224

ChondroMimetic – Product Status 225

ChondroMimetic – Product Description 225

Collplant Biotechnologies Ltd Pipeline Products & Ongoing Clinical Trials Overview 226

Absorbable Bio-active Surgical Matrix – Spinal Fusion – Product Status 226

Absorbable Bio-active Surgical Matrix – Spinal Fusion – Product Description 227

Vergenix BVF – Product Status 227

Vergenix BVF – Product Description 227

Vergenix PBR – Product Status 228

Vergenix PBR – Product Description 228

Vergenix STR – Anterior Cruciate Ligament – Product Status 228

Vergenix STR – Anterior Cruciate Ligament – Product Description 229

Vergenix STR – Rotator Cuff Repair – Product Status 229

Vergenix STR – Rotator Cuff Repair – Product Description 229

Vergenix TRA – Product Status 230

Vergenix TRA – Product Description 230

Colorado Therapeutics, LLC Pipeline Products & Ongoing Clinical Trials Overview 231

Xenograft Implant – Orthopedic Foot – Product Status 231

Xenograft Implant – Orthopedic Foot – Product Description 231

Xenograft Implant – Orthopedic Knee – Product Status 232

Xenograft Implant – Orthopedic Knee – Product Description 232

Xenograft Implant – Orthopedic Shoulder – Product Status 232

Xenograft Implant – Orthopedic Shoulder – Product Description 233

Connective Orthopaedics Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 234

ACL Reconstruction Device – Product Status 234

ACL Reconstruction Device – Product Description 234

Contura International A/S Pipeline Products & Ongoing Clinical Trials Overview 235

Arthrosamid – Product Status 235

Arthrosamid – Product Description 235

Contura International A/S – Ongoing Clinical Trials Overview 236

Arthrosamid – A Multi-centre Randomized, Controlled, Double-blind Clinical Investigation of Intra-articular Polyacrylamide Hydrogel in Subjects with Knee Osteoarthritis Followed by an Open Label Extension Study 237

Arthrosamid – Mechanistic and Clinical Study of Intra-articular Arthrosamid for Knee Osteoarthritis 237

Core Essence Orthopaedics, LLC Pipeline Products & Ongoing Clinical Trials Overview 238

Soft Tissue Repair Device – Extremities – Product Status 238

Soft Tissue Repair Device – Extremities – Product Description 238

CoreSpine Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 239

Cartilage Removal System – Product Status 239

Cartilage Removal System – Product Description 239

Curative Biosciences, Inc. Pipeline Products & Ongoing Clinical Trials Overview 240

Nurture BSP – Product Status 240

Nurture BSP – Product Description 240

Osteoconductive Scaffold – Product Status 241

Osteoconductive Scaffold – Product Description 241

Cyfuse Biomedical KK Pipeline Products & Ongoing Clinical Trials Overview 242

Cellular Bone And Cartilage – Product Status 242

Cellular Bone And Cartilage – Product Description 242

Daewoong Pharmaceutical Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 243

Bongros HA – Product Status 243

Bongros HA – Product Description 243

NOVOSIS – Spinal Fusion – Product Status 244

NOVOSIS – Spinal Fusion – Product Description 244

Department of Biomedical Engineering Columbia University Pipeline Products & Ongoing Clinical Trials Overview 245

Echon – Product Status 245

Echon – Product Description 245

Rotator Cuff Repair Graft – Product Status 246

Rotator Cuff Repair Graft – Product Description 246

DePuy Mitek, LLC Pipeline Products & Ongoing Clinical Trials Overview 247

Cartilage Autograft Implantation System – Product Status 247

Cartilage Autograft Implantation System – Product Description 247

Dimension Inx LLC Pipeline Products & Ongoing Clinical Trials Overview 248

3D-Printed Implant – Facial Reconstruction – Product Status 248

3D-Printed Implant – Facial Reconstruction – Product Description 248

3D-Printed Implant – Tracheal Repair – Product Status 249

3D-Printed Implant – Tracheal Repair – Product Description 249

3D-Printed Scaffold – Spinal Fusion – Product Status 249

3D-Printed Scaffold – Spinal Fusion – Product Description 250

Hyperelastic Bone – Product Status 250

Hyperelastic Bone – Product Description 250

DJO Global Inc Pipeline Products & Ongoing Clinical Trials Overview 251

CMF OL1000 – Fresh Ankle Fracture – Product Status 251

CMF OL1000 – Fresh Ankle Fracture – Product Description 251

DJO Global Inc – Ongoing Clinical Trials Overview 252

CMF OL1000 – Fresh Ankle Fracture – Prospective, Randomized, Double-blinded, Controlled Multi-center Clinical Trial Evaluating the Use of Non-invasive CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures 253

Drexel University Pipeline Products & Ongoing Clinical Trials Overview 254

Biodegradable Polymer Scaffold – Product Status 254

Biodegradable Polymer Scaffold – Product Description 254

Muscle-Polymer Constructs – Product Status 254

Muscle-Polymer Constructs – Product Description 255

DSM Biomedical BV Pipeline Products & Ongoing Clinical Trials Overview 256

Structural Synthetic Bone Graft – Product Status 256

Structural Synthetic Bone Graft – Product Description 256

Duke University Pipeline Products & Ongoing Clinical Trials Overview 257

TLDM Patch – Product Status 257

TLDM Patch – Product Description 257

Eepta Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 258

Bone Growth Scaffold – Product Status 258

Bone Growth Scaffold – Product Description 258

Eindhoven University of Technology Pipeline Products & Ongoing Clinical Trials Overview 259

Bone Tissue Engineering System – Product Status 259

Bone Tissue Engineering System – Product Description 259

Meniscus Implant – Product Status 260

Meniscus Implant – Product Description 260

Element Orthopedics Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 261

Beads-On-A-String Spinal Implant – Product Status 261

Beads-On-A-String Spinal Implant – Product Description 261

Elute Inc Pipeline Products & Ongoing Clinical Trials Overview 262

EP Granules With Tobramycin – Product Status 262

EP Granules With Tobramycin – Product Description 262

ElutInc Pipeline Products & Ongoing Clinical Trials Overview 263

ElutiBone – Product Status 263

ElutiBone – Product Description 263

Implantable Drug Eluting Device – Product Status 264

Implantable Drug Eluting Device – Product Description 264

Ember Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 265

BMP-7 – Osteoarthritis – Product Status 265

BMP-7 – Osteoarthritis – Product Description 265

Embody LLC Pipeline Products & Ongoing Clinical Trials Overview 266

Bio-TEND – Product Status 266

Bio-TEND – Product Description 266

Microbrace – Product Status 267

Microbrace – Product Description 267

EpiBone Inc Pipeline Products & Ongoing Clinical Trials Overview 268

EpiBone-CMF – Product Status 268

EpiBone-CMF – Product Description 268

EpiBone Inc – Ongoing Clinical Trials Overview 269

EpiBone-CMF – An Open-label, First-in-human, Single Intervention Study for Evaluation of EpiBone-CMF Engineered Living Bone Graft for Mandibular Ramus Reconstruction 270

Eskisehir Osmangazi University Pipeline Products & Ongoing Clinical Trials Overview 271

Antimicrobial Synthetic Bone Graft – Product Status 271

Antimicrobial Synthetic Bone Graft – Product Description 271

EternoGen Aesthetics LLC Pipeline Products & Ongoing Clinical Trials Overview 272

Collagen Scaffold – Orthopedic Procedures – Product Status 272

Collagen Scaffold – Orthopedic Procedures – Product Description 272

Evonik Corp Pipeline Products & Ongoing Clinical Trials Overview 273

VESTAKEEP PEEK With Barium Sulfate (BaSO4) – Product Status 273

VESTAKEEP PEEK With Barium Sulfate (BaSO4) – Product Description 273

Exactech Inc Pipeline Products & Ongoing Clinical Trials Overview 274

Cartilage Allograft – Product Status 274

Cartilage Allograft – Product Description 274

ExceeMatrix (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 275

ACL Implant – Product Status 275

ACL Implant – Product Description 275

Ferring Pharmaceuticals AS Pipeline Products & Ongoing Clinical Trials Overview 276

AMPLEX Osteo-Promotive Bone Graft System – Cervical Spine Fusion – Product Status 276

AMPLEX Osteo-Promotive Bone Graft System – Cervical Spine Fusion – Product Description 276

AMPLEX Osteo-Promotive Bone Graft System – Foot & Ankle Fusion – Product Status 277

AMPLEX Osteo-Promotive Bone Graft System – Foot & Ankle Fusion – Product Description 277

AMPLEX Osteo-Promotive Bone Graft System – Lumbar Spine Fusion – Product Status 277

AMPLEX Osteo-Promotive Bone Graft System – Lumbar Spine Fusion – Product Description 278

Biomaterial Scaffold – Fracture Repair – Product Status 278

Biomaterial Scaffold – Fracture Repair – Product Description 278

Biomaterial Scaffold – Trauma – Product Status 279

Biomaterial Scaffold – Trauma – Product Description 279

Flex Biomedical Inc Pipeline Products & Ongoing Clinical Trials Overview 280

Flex Polymer – Product Status 280

Flex Polymer – Product Description 280

Formae, Inc. Pipeline Products & Ongoing Clinical Trials Overview 281

ArthroPad – Product Status 281

ArthroPad – Product Description 281

Forsagen LLC Pipeline Products & Ongoing Clinical Trials Overview 282

BioAdhesive – Product Status 282

BioAdhesive – Product Description 282

Forticell Bioscience Inc Pipeline Products & Ongoing Clinical Trials Overview 283

Haptides Bone Regeneration – Product Status 283

Haptides Bone Regeneration – Product Description 283

Fuse Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 284

FusePure Demineralized Bone Matrix – Product Status 284

FusePure Demineralized Bone Matrix – Product Description 284

FuseTrilogy Viable Bone Matrix – Product Status 285

FuseTrilogy Viable Bone Matrix – Product Description 285

Geistlich Pharma AG Pipeline Products & Ongoing Clinical Trials Overview 286

Chondro-Gide – Product Status 286

Chondro-Gide – Product Description 286

Gel-Del Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 287

OrthoGelic – Product Status 287

OrthoGelic – Product Description 287

OrthoMetic – Product Status 288

OrthoMetic – Product Description 288

Gene Biotherapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 289

Osteorate – Product Status 289

Osteorate – Product Description 289

George Washington University Pipeline Products & Ongoing Clinical Trials Overview 290

3D Bioprinte

Figures

Orthobiologics – Pipeline Products by Stage of Development 49

Orthobiologics – Pipeline Products by Segment 50

Orthobiologics – Pipeline Products by Territory 52

Orthobiologics – Pipeline Products by Regulatory Path 54

Orthobiologics – Pipeline Products by Estimated Approval Date 55

Orthobiologics – Ongoing Clinical Trials 56

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