Tissue Sealants Pipeline by Development Stages, Segments, Region and Countries, Regulatory Path and Key Companies

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Tissue Sealants Pipeline Market Report Overview

A tissue sealant serves as a physical barrier to prevent leakage of fluid and/or gas from a surgical incision. These sealants can be used to hold the flaps of internal organs together, to seal the blood vessels in injury or surgery, or as an adjunct with hemostatic agents. The volume of tissue sealant used per procedure varies depending on the type of procedure and formulation.

The Tissue Sealants pipeline market research report provides a comprehensive understanding of the pipeline products along with their comparative analysis at various stages of development. The report also includes information about the territories wherein the clinical trials are in progress, the regulatory paths followed by the trials, and the companies associated with the trials.

Key Segments ·        Synthetic Tissue Sealants

·        Fibrin Based Tissue Sealants

·        Other Protein-Based Tissue Sealants

·        Combination Hemostats – Flowables

·        Fibrin Based Tissue Sealants in Liquid Form

Key Territories ·        The US

·        Europe

·        Canada

·        China

·        Australia

Key Regulatory Paths ·        510(K)

·        CE

·        TGA

·        MDL

·        NMPA

Leading Companies ·        Advanced Medical Solutions Group plc

·        Aleo BME Inc

·        Angiotech Pharmaceuticals Inc

·        Arch Therapeutics Inc

·        Arizona State University

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Tissue Sealants Pipeline Market by Segments

The key segments in the Tissue Sealants pipeline market are Synthetic Tissue Sealants, Fibrin Based Tissue Sealants, Other Protein-Based Tissue Sealants, Combination Hemostats – Flowables, and Fibrin Based Tissue Sealants in Liquid Form. As of December 2023, Synthetic Tissue Sealants accounted for the highest number of pipeline products. Synthetic Tissue Sealants are made of chemical compounds that consist of a variety of artificial components. Polyethylene glycol, synthetic peptides, and protein polymers are a few examples of the artificial components used in the manufacturing of Synthetic Tissue Sealants.

Tissue Sealants Pipeline Market Analysis by Segments, 2023 (%)

Tissue Sealants Pipeline Market Analysis by Segments, 2023 (%)

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Tissue Sealants Pipeline Market Segmentation by Territories

A few of the key territories for Tissue Sealants pipeline products are the US, Europe, Canada, China, and Australia among others. As of December 2023, the US accounted for the highest number of pipeline products.

Tissue Sealants Pipeline Market Analysis by Territories, 2023 (%)

Tissue Sealants Pipeline Market Analysis by Territories, 2023 (%)

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Tissue Sealants Pipeline Market Segmentation by Regulatory Paths

A few of the key regulatory paths followed by the Tissue Sealants pipeline market are 510(K), CE, TGA, MDL, and NMPA among others. As of December 2023, 510(K) was the most followed pathway for pipeline products in the market.

Tissue Sealants Pipeline Market Analysis by Regulatory Paths, 2023 (%)

Tissue Sealants Pipeline Market Analysis by Regulatory Paths, 2023 (%)

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Tissue Sealants Pipeline Market – Competitive Landscape

A few of the key companies associated with the Tissue Sealants pipeline market are Advanced Medical Solutions Group plc, Aleo BME Inc., Angiotech Pharmaceuticals Inc., Arch Therapeutics Inc., and Arizona State University among others.

Advanced Medical Solutions Group plc (AMS): AMS is headquartered in Winsford, Cheshire, the UK. The company designs, manufactures and distributes wound care dressings and medical adhesives for closing wounds and sealing tissues. The company’s products include tissue adhesives, collagen, sutures, oxidized cellulose, internal fixation, alginate sealants, and antimicrobial dressings among others. These products are distributed through major wound care partners and private-label distributors. Apart from its operations in the UK, the company also has a strong presence in the Netherlands, France, Germany, the Czech Republic, Israel, and Russia.

Tissue Sealants Pipeline Market Analysis by Companies, 2023

Tissue Sealants Pipeline Market Analysis by Companies, 2023

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Segments Covered in the Report

Tissue Sealants Pipeline Market Segments Outlook

  • Synthetic Tissue Sealants
  • Fibrin Based Tissue Sealants
  • Other Protein-Based Tissue Sealants
  • Combination Hemostats – Flowables
  • Fibrin Based Tissue Sealants in Liquid Form

Tissue Sealants Pipeline Market Territories Outlook

  • The US
  • Europe
  • Canada
  • China
  • Australia

Tissue Sealants Pipeline Market Regulatory Paths Outlook

  • 510(K)
  • CE
  • TGA
  • MDL
  • NMPA

Scope

This report provides:

  • Extensive coverage of the Tissue Sealants under development.
  • An exhaustive list of major pipeline products and their details, including product descriptions, licensing and collaboration details, and other developmental activities.
  • Reviews of major players involved in the development of Tissue Sealants and lists all their pipeline projects.
  • Coverage of pipeline products based on various stages of development ranging from early development to approved/issued stage.
  • Key clinical trial data of ongoing clinical trials specific to pipeline products.
  • Recent developments in the segment/industry.

Reasons to Buy

The report will enable you to:

  • Formulate significant competitor information, analysis, and insights to improve R&D strategies.
  • Identify emerging players with potentially strong product portfolios and create effective counter strategies to gain a competitive advantage.
  • Identify and understand important and diverse types of Tissue Sealants under development.
  • Develop market-entry and market-expansion strategies.
  • Plan mergers and acquisitions effectively by identifying major players with the most promising pipeline.
  • Carry out In-depth analysis of the product’s current stage of development, territory, and estimated launch date.

Advanced Medical Solutions Group plc
Aleo BME Inc
Angiotech Pharmaceuticals Inc
Arch Therapeutics Inc
Arizona State University
Baxter International Inc
Biomedica Management Corp
Boston University
Calmare Therapeutics Inc
Clemson University
Cohera Medical Inc
Covalent Medical, Inc. (Inactive)
CR Bard Inc
Department of Biomedical Engineering Columbia University
DSM Biomedical BV
Eidgenossische Materialprufungs- und Forschungsanstalt
Elastagen Pty Ltd
Ethicon Endo-Surgery Inc
Gamma Diagnostics Inc
GATT Technologies BV
Hemostasis LLC
HyperBranch Medical Technology Inc
Innotherapy Inc
Institute of Molecular Biology of Parana
InVivo Therapeutics Corp
Johns Hopkins University
Kollodis BioSciences Inc
Kuros Biosciences AG
Laser Tissue Welding, Inc.
Medisse BV (Inactive)
Meril Life Sciences Pvt Ltd
Nurami Medical Ltd
Pharming Group NV
Polyganics BV
Protein Polymer Technologies Inc (Inactive)
Purdue University
Samyang Biopharmaceuticals Corp
Sea Run Holdings Inc
Sealantis Ltd.
Sealonix Inc
Selio Medical
Shanghai Haohai Biological Technology Co Ltd
Surgical Sealants, Inc.
Teijin Pharma Ltd
Terasaki Institute for Biomedical Innovation
Tetratherix Pty Ltd
Texas A&M Engineering Experiment Station
Texas A&M University
The Medicines Co
Tissium SA
University of Akron

Table of Contents

|1 Table of Contents 3

|1.1 List of Tables 7

|1.2 List of Figures 11

2 Introduction 12

2.1 Tissue Sealants Overview 12

3 Products under Development 13

3.1 Tissue Sealants – Pipeline Products by Stage of Development 13

3.2 Tissue Sealants – Pipeline Products by Segment 14

3.3 Tissue Sealants – Pipeline Products by Territory 15

3.4 Tissue Sealants – Pipeline Products by Regulatory Path 16

3.5 Tissue Sealants – Pipeline Products by Estimated Approval Date 17

3.6 Tissue Sealants – Ongoing Clinical Trials 18

4 Tissue Sealants – Pipeline Products under Development by Companies 19

4.1 Tissue Sealants Companies – Pipeline Products by Stage of Development 19

4.2 Tissue Sealants – Pipeline Products by Stage of Development 21

5 Tissue Sealants Companies and Product Overview 23

5.1 Advanced Medical Solutions Group plc Company Overview 23

5.1.1 Advanced Medical Solutions Group plc Pipeline Products & Ongoing Clinical Trials Overview 23

5.2 Aleo BME Inc Company Overview 24

5.2.1 Aleo BME Inc Pipeline Products & Ongoing Clinical Trials Overview 24

5.3 Angiotech Pharmaceuticals Inc Company Overview 26

5.3.1 Angiotech Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 26

5.4 Arch Therapeutics Inc Company Overview 27

5.4.1 Arch Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 27

5.5 Arizona State University Company Overview 28

5.5.1 Arizona State University Pipeline Products & Ongoing Clinical Trials Overview 28

5.6 Baxter International Inc Company Overview 29

5.6.1 Baxter International Inc Pipeline Products & Ongoing Clinical Trials Overview 29

5.7 Biomedica Management Corp Company Overview 31

5.7.1 Biomedica Management Corp Pipeline Products & Ongoing Clinical Trials Overview 31

5.8 Boston University Company Overview 32

5.8.1 Boston University Pipeline Products & Ongoing Clinical Trials Overview 32

5.9 Calmare Therapeutics Inc Company Overview 33

5.9.1 Calmare Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 33

5.10 Clemson University Company Overview 34

5.10.1 Clemson University Pipeline Products & Ongoing Clinical Trials Overview 34

5.11 Cohera Medical Inc Company Overview 35

5.11.1 Cohera Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 35

5.12 Covalent Medical, Inc. (Inactive) Company Overview 37

5.12.1 Covalent Medical, Inc. (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 37

5.13 CR Bard Inc Company Overview 38

5.13.1 CR Bard Inc Pipeline Products & Ongoing Clinical Trials Overview 38

5.14 Department of Biomedical Engineering Columbia University Company Overview 41

5.14.1 Department of Biomedical Engineering Columbia University Pipeline Products & Ongoing Clinical Trials Overview 41

5.15 DSM Biomedical BV Company Overview 42

5.15.1 DSM Biomedical BV Pipeline Products & Ongoing Clinical Trials Overview 42

5.16 Eidgenossische Materialprufungs- und Forschungsanstalt Company Overview 43

5.16.1 Eidgenossische Materialprufungs- und Forschungsanstalt Pipeline Products & Ongoing Clinical Trials Overview 43

5.17 Elastagen Pty Ltd Company Overview 44

5.17.1 Elastagen Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 44

5.18 Ethicon Endo-Surgery Inc Company Overview 45

5.18.1 Ethicon Endo-Surgery Inc Pipeline Products & Ongoing Clinical Trials Overview 45

5.19 Gamma Diagnostics Inc Company Overview 46

5.19.1 Gamma Diagnostics Inc Pipeline Products & Ongoing Clinical Trials Overview 46

5.20 GATT Technologies BV Company Overview 47

5.20.1 GATT Technologies BV Pipeline Products & Ongoing Clinical Trials Overview 47

5.21 Hemostasis LLC Company Overview 49

5.21.1 Hemostasis LLC Pipeline Products & Ongoing Clinical Trials Overview 49

5.22 HyperBranch Medical Technology Inc Company Overview 50

5.22.1 HyperBranch Medical Technology Inc Pipeline Products & Ongoing Clinical Trials Overview 50

5.23 Innotherapy Inc Company Overview 52

5.23.1 Innotherapy Inc Pipeline Products & Ongoing Clinical Trials Overview 52

5.24 Institute of Molecular Biology of Parana Company Overview 53

5.24.1 Institute of Molecular Biology of Parana Pipeline Products & Ongoing Clinical Trials Overview 53

5.25 InVivo Therapeutics Corp Company Overview 54

5.25.1 InVivo Therapeutics Corp Pipeline Products & Ongoing Clinical Trials Overview 54

5.26 Johns Hopkins University Company Overview 55

5.26.1 Johns Hopkins University Pipeline Products & Ongoing Clinical Trials Overview 55

5.27 Kollodis BioSciences Inc Company Overview 56

5.27.1 Kollodis BioSciences Inc Pipeline Products & Ongoing Clinical Trials Overview 56

5.28 Kuros Biosciences AG Company Overview 57

5.28.1 Kuros Biosciences AG Pipeline Products & Ongoing Clinical Trials Overview 57

5.29 Laser Tissue Welding, Inc. Company Overview 59

5.29.1 Laser Tissue Welding, Inc. Pipeline Products & Ongoing Clinical Trials Overview 59

5.30 Medisse BV (Inactive) Company Overview 60

5.30.1 Medisse BV (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 60

5.31 Meril Life Sciences Pvt Ltd Company Overview 61

5.31.1 Meril Life Sciences Pvt Ltd Pipeline Products & Ongoing Clinical Trials Overview 61

5.32 Nurami Medical Ltd Company Overview 62

5.32.1 Nurami Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview 62

5.33 Pharming Group NV Company Overview 63

5.33.1 Pharming Group NV Pipeline Products & Ongoing Clinical Trials Overview 63

5.34 Polyganics BV Company Overview 64

5.34.1 Polyganics BV Pipeline Products & Ongoing Clinical Trials Overview 64

5.35 Protein Polymer Technologies Inc (Inactive) Company Overview 69

5.35.1 Protein Polymer Technologies Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 69

5.36 Purdue University Company Overview 70

5.36.1 Purdue University Pipeline Products & Ongoing Clinical Trials Overview 70

5.37 Samyang Biopharmaceuticals Corp Company Overview 71

5.37.1 Samyang Biopharmaceuticals Corp Pipeline Products & Ongoing Clinical Trials Overview 71

5.38 Sea Run Holdings Inc Company Overview 72

5.38.1 Sea Run Holdings Inc Pipeline Products & Ongoing Clinical Trials Overview 72

5.39 Sealantis Ltd. Company Overview 73

5.39.1 Sealantis Ltd. Pipeline Products & Ongoing Clinical Trials Overview 73

5.40 Sealonix Inc Company Overview 76

5.40.1 Sealonix Inc Pipeline Products & Ongoing Clinical Trials Overview 76

5.41 Selio Medical Company Overview 77

5.41.1 Selio Medical Pipeline Products & Ongoing Clinical Trials Overview 77

5.42 Shanghai Haohai Biological Technology Co Ltd Company Overview 78

5.42.1 Shanghai Haohai Biological Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 78

5.43 Surgical Sealants, Inc. Company Overview 79

5.43.1 Surgical Sealants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 79

5.44 Teijin Pharma Ltd Company Overview 80

5.44.1 Teijin Pharma Ltd Pipeline Products & Ongoing Clinical Trials Overview 80

5.45 Terasaki Institute for Biomedical Innovation Company Overview 81

5.45.1 Terasaki Institute for Biomedical Innovation Pipeline Products & Ongoing Clinical Trials Overview 81

5.46 Tetratherix Pty Ltd Company Overview 82

5.46.1 Tetratherix Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 82

5.47 Texas A&M Engineering Experiment Station Company Overview 83

5.47.1 Texas A&M Engineering Experiment Station Pipeline Products & Ongoing Clinical Trials Overview 83

5.48 Texas A&M University Company Overview 84

5.48.1 Texas A&M University Pipeline Products & Ongoing Clinical Trials Overview 84

5.49 The Medicines Co Company Overview 86

5.49.1 The Medicines Co Pipeline Products & Ongoing Clinical Trials Overview 86

5.50 Tissium SA Company Overview 87

5.50.1 Tissium SA Pipeline Products & Ongoing Clinical Trials Overview 87

5.51 University of Akron Company Overview 89

5.51.1 University of Akron Pipeline Products & Ongoing Clinical Trials Overview 89

6 Tissue Sealants- Recent Developments 90

6.1 Dec 07, 2023: Johnson & Johnson to Participate in the 42nd Annual J.P. Morgan Healthcare Conference 90

6.2 Nov 30, 2023: Johnson & Johnson Names Eugene A. Woods, Chief Executive Officer of Advocate Health, to its Board of Directors 90

6.3 Nov 08, 2023: ThermoGenesis Holdings to Announce Financial Results for the Third Quarter Ended September 30, 2023, and Provide a Corporate Strategic Update 90

6.4 Nov 07, 2023: Asahi Kasei Announces Consolidated Results for 1st and 2nd Quarter Fiscal 2023: April 1, 2023 – September 30, 2023 90

6.5 Oct 19, 2023: Artivion Announces Release Date and Teleconference Call Details for Third Quarter 2023 Financial Results 91

6.6 Oct 18, 2023: NeoDyne Launches New UK Headquarters to Mark Growth and Expansion in the UK 91

6.7 Oct 17, 2023: Johnson & Johnson Reports Q3 2023 Results 91

6.8 Oct 04, 2023: Boston University Names Melissa L. Gilliam 11th President 92

6.9 Oct 04, 2023: Medtronic Names Paolo Di Vincenzo President of the Neuromodulation Business 93

6.10 Oct 03, 2023: Baxter Appoints Joel Grade Chief Financial Officer 93

6.11 Oct 02, 2023: Advanced Medical Solutions Group Announces Appointment of New Chair 94

6.12 Sep 19, 2023: Baxter to Host Third-Quarter 2023 Financial Results Conference Call for Investors 95

6.13 Sep 06, 2023: ThermoGenesis Holdings to Present at the H.C. Wainwright 25th Annual Global Investment Conference 95

6.14 Sep 04, 2023: Grifols names Dr. Jorg Schüttrumpf Chief Scientific Innovation Officer 95

6.15 Aug 26, 2023: Medtronic Q2 2024 Earnings Estimates Increased by William Blair 96

6.16 Aug 21, 2023: Johnson & Johnson Announces Preliminary Results of Kenvue Inc. Exchange Offer 96

6.17 Aug 10, 2023: Advanced Medical Solutions Group Notice of Interim Results 96

6.18 Aug 08, 2023: ThermoGenesis Holdings to Announce Financial Results for the Second Quarter ended June 30, 2023 and Provide a Corporate Strategic Update 97

6.19 Aug 08, 2023: Medtronic to Announce Financial Results for its First Quarter of Fiscal Year 2024 97

6.20 Jul 18, 2023: Pramand Obtains Pre-Market Approval (PMA) for CraniSeal Dural Sealant 97

6.21 Jun 28, 2023: Medline Announces Leadership Transition Naming New CEO and President & COO 97

6.22 May 15, 2023: Sealonix receives funding for sealant products development 98

6.23 May 11, 2023: Medtronic to announce financial results for its fourth quarter and full fiscal year 2023 99

6.24 May 10, 2023: ThermoGenesis Holdings to Announce Financial Results for the First Quarter Ended March 31, 2023 and Provide a Corporate Strategic Update 99

6.25 May 09, 2023: Grifols delivers strong first quarter financials with 23% revenue growth and an adjusted EBITDA margin above guidance of 21% 99

6.26 Apr 20, 2023: Corza Medical announces direct distribution of TachoSil to the US Market 101

6.27 Apr 18, 2023: Johnson & Johnson Reports Q1 2023 Results 101

6.28 Apr 12, 2023: Medtronic has a layoff in California 103

6.29 Apr 11, 2023: J&J talc unit 2nd bankruptcy must be dismissed 104

6.30 Apr 03, 2023: Baxter Showcases Surgical Innovations at AORN Global Surgical Conference and Expo 2023 104

6.31 Mar 30, 2023: Surgical Sealing made better with robust Thermosensitive Bioadhesives 105

6.32 Mar 30, 2023: ThermoGenesis Holdings Announces Year End 2022 Financial Results and Provides Corporate Update 106

6.33 Mar 29, 2023: Baxter to Host Annual Meeting of Stockholders in Virtual Format 107

6.34 Mar 28, 2023: ThermoGenesis Holdings to Announce Financial Results for the Year Ended December 31, 2022 and Provide a Corporate Strategic Update 107

6.35 Mar 16, 2023: Thermogenesis Announces $3 Million Private Placement Priced at-the-market Under Nasdaq Rules 107

6.36 Mar 16, 2023: Medtronic joins in $25M funding round for home monitoring company 107

6.37 Mar 08, 2023: Asahi Kasei Corp. Announces Change in Representative Directors 108

6.38 Mar 03, 2023: Grifols Announces Full Year 2022 Earnings 108

6.39 Feb 22, 2023: Thomas Glanzmann new Grifols Executive Chairman, after Steven F. Mayer resignation 108

6.40 Feb 09, 2023: Baxter Reports Fourth-Quarter and Full-Year 2022 Results 109

6.41 Feb 08, 2023: Asahi Kasei Announces Consolidated Results for 1st to 3rd Quarter Fiscal 2022 111

7 Appendix 112

7.1 Methodology 112

7.2 About GlobalData 115

7.3 Contact Us 115

7.4 Disclaimer 115

Table

Tissue Sealants – Pipeline Products by Stage of Development 13

Tissue Sealants – Pipeline Products by Segment 14

Tissue Sealants – Pipeline Products by Territory 15

Tissue Sealants – Pipeline Products by Regulatory Path 16

Tissue Sealants – Pipeline Products by Estimated Approval Date 17

Tissue Sealants – Ongoing Clinical Trials 18

Tissue Sealants Companies – Pipeline Products by Stage of Development 19

Tissue Sealants – Pipeline Products by Stage of Development 21

Advanced Medical Solutions Group plc Pipeline Products & Ongoing Clinical Trials Overview 23

Next Generation Internal Fixation And Sealant Device – Product Status 23

Next Generation Internal Fixation And Sealant Device – Product Description 23

Aleo BME Inc Pipeline Products & Ongoing Clinical Trials Overview 24

Dural Sealant – Product Status 24

Dural Sealant – Product Description 24

Surgical Sealant – Product Status 25

Surgical Sealant – Product Description 25

Angiotech Pharmaceuticals Inc Pipeline Products & Ongoing Clinical Trials Overview 26

Hemaseel HMN Fibrin Sealant – Product Status 26

Hemaseel HMN Fibrin Sealant – Product Description 26

Arch Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 27

AC5 Surgery – Sealant – Product Status 27

AC5 Surgery – Sealant – Product Description 27

Arizona State University Pipeline Products & Ongoing Clinical Trials Overview 28

Laser-Activated Nanosealant – Product Status 28

Laser-Activated Nanosealant – Product Description 28

Baxter International Inc Pipeline Products & Ongoing Clinical Trials Overview 29

Floseal + Recothrom 10mL – Product Status 29

Floseal + Recothrom 10mL – Product Description 29

Tisseel Dura – Product Status 30

Tisseel Dura – Product Description 30

Biomedica Management Corp Pipeline Products & Ongoing Clinical Trials Overview 31

ClotBlock – Product Status 31

ClotBlock – Product Description 31

Boston University Pipeline Products & Ongoing Clinical Trials Overview 32

Hydrogel-Based Aerosolized Sealant Dressing – Product Status 32

Hydrogel-Based Aerosolized Sealant Dressing – Product Description 32

Calmare Therapeutics Inc Pipeline Products & Ongoing Clinical Trials Overview 33

Wound Sealant – Product Status 33

Wound Sealant – Product Description 33

Clemson University Pipeline Products & Ongoing Clinical Trials Overview 34

Surgical Adhesive Hydrogel – Product Status 34

Surgical Adhesive Hydrogel – Product Description 34

Cohera Medical Inc Pipeline Products & Ongoing Clinical Trials Overview 35

Sylys Surgical Sealant – Drug Delivery – Product Status 35

Sylys Surgical Sealant – Drug Delivery – Product Description 35

Sylys Surgical Sealant – Hernia Mesh Fixation – Product Status 36

Sylys Surgical Sealant – Hernia Mesh Fixation – Product Description 36

Sylys Surgical Sealant – Orthopedic – Product Status 36

Sylys Surgical Sealant – Orthopedic – Product Description 36

Covalent Medical, Inc. (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 37

Covabond – Product Status 37

Covabond – Product Description 37

CR Bard Inc Pipeline Products & Ongoing Clinical Trials Overview 38

Progel Dural Sealant – Product Status 38

Progel Dural Sealant – Product Description 38

Progel Emerald – Product Status 39

Progel Emerald – Product Description 39

ProGEL-VS – Product Status 39

ProGEL-VS – Product Description 39

Tissue Adhesive – Product Status 40

Tissue Adhesive – Product Description 40

Tridyne Peripheral – Product Status 40

Tridyne Peripheral – Product Description 40

Department of Biomedical Engineering Columbia University Pipeline Products & Ongoing Clinical Trials Overview 41

Biomimetic Lung Sealant – Product Status 41

Biomimetic Lung Sealant – Product Description 41

DSM Biomedical BV Pipeline Products & Ongoing Clinical Trials Overview 42

Dural Membrane Sealant – Product Status 42

Dural Membrane Sealant – Product Description 42

Eidgenossische Materialprufungs- und Forschungsanstalt Pipeline Products & Ongoing Clinical Trials Overview 43

Polymer Patch – Product Status 43

Polymer Patch – Product Description 43

Elastagen Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 44

MeTro – Surgical Glue – Product Status 44

MeTro – Surgical Glue – Product Description 44

Ethicon Endo-Surgery Inc Pipeline Products & Ongoing Clinical Trials Overview 45

Bioseal Next Gen Device – Product Status 45

Bioseal Next Gen Device – Product Description 45

Gamma Diagnostics Inc Pipeline Products & Ongoing Clinical Trials Overview 46

GammaSeal – Product Status 46

GammaSeal – Product Description 46

GATT Technologies BV Pipeline Products & Ongoing Clinical Trials Overview 47

GATT-Spray – Product Status 47

GATT-Spray – Product Description 47

GATT-Tape – Product Status 48

GATT-Tape – Product Description 48

Hemostasis LLC Pipeline Products & Ongoing Clinical Trials Overview 49

Advanced Tissue Sealant – Product Status 49

Advanced Tissue Sealant – Product Description 49

HyperBranch Medical Technology Inc Pipeline Products & Ongoing Clinical Trials Overview 50

Adherus Vascular Sealant – Product Status 50

Adherus Vascular Sealant – Product Description 50

Tissue Plane Sealant – Product Status 51

Tissue Plane Sealant – Product Description 51

Innotherapy Inc Pipeline Products & Ongoing Clinical Trials Overview 52

Surgical Sealant Film – Product Status 52

Surgical Sealant Film – Product Description 52

Institute of Molecular Biology of Parana Pipeline Products & Ongoing Clinical Trials Overview 53

Recombinant Fibrin Glue – Product Status 53

Recombinant Fibrin Glue – Product Description 53

InVivo Therapeutics Corp Pipeline Products & Ongoing Clinical Trials Overview 54

InVivoSeal – Product Status 54

InVivoSeal – Product Description 54

Johns Hopkins University Pipeline Products & Ongoing Clinical Trials Overview 55

Chondroitin Sulfate-based Adhesive – Product Status 55

Chondroitin Sulfate-based Adhesive – Product Description 55

Kollodis BioSciences Inc Pipeline Products & Ongoing Clinical Trials Overview 56

Hemostat Sealant – Product Status 56

Hemostat Sealant – Product Description 56

Kuros Biosciences AG Pipeline Products & Ongoing Clinical Trials Overview 57

KUR – 211 – Product Status 57

KUR – 211 – Product Description 57

KUR – 212 – Product Status 58

KUR – 212 – Product Description 58

Laser Tissue Welding, Inc. Pipeline Products & Ongoing Clinical Trials Overview 59

Laser Tissue Welding Device – Product Status 59

Laser Tissue Welding Device – Product Description 59

Medisse BV (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 60

PTMC Sealant – Product Status 60

PTMC Sealant – Product Description 60

Meril Life Sciences Pvt Ltd Pipeline Products & Ongoing Clinical Trials Overview 61

PeriTi – Product Status 61

PeriTi – Product Description 61

Nurami Medical Ltd Pipeline Products & Ongoing Clinical Trials Overview 62

ArtiFix – Product Status 62

ArtiFix – Product Description 62

Pharming Group NV Pipeline Products & Ongoing Clinical Trials Overview 63

Recombinant Fibrin Tissue Sealant – Product Status 63

Recombinant Fibrin Tissue Sealant – Product Description 63

Polyganics BV Pipeline Products & Ongoing Clinical Trials Overview 64

ACTISEAL – Product Status 64

ACTISEAL – Product Description 64

ACTISEAL – Adjacent Indications – Product Status 65

ACTISEAL – Adjacent Indications – Product Description 65

LIQOSEAL – Dura Sealing Patch – Product Status 65

LIQOSEAL – Dura Sealing Patch – Product Description 66

LIQOSEAL – Spine Application – Product Status 66

LIQOSEAL – Spine Application – Product Description 66

Polyganics BV – Ongoing Clinical Trials Overview 67

LIQOSEAL – Dura Sealing Patch – Randomized, Two-arm, Multicenter Study to Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery 68

Protein Polymer Technologies Inc (Inactive) Pipeline Products & Ongoing Clinical Trials Overview 69

Surgical Tissue Sealant – Product Status 69

Surgical Tissue Sealant – Product Description 69

Purdue University Pipeline Products & Ongoing Clinical Trials Overview 70

Surgical Sealant – Product Status 70

Surgical Sealant – Product Description 70

Samyang Biopharmaceuticals Corp Pipeline Products & Ongoing Clinical Trials Overview 71

Surgical Sealant – Product Status 71

Surgical Sealant – Product Description 71

Sea Run Holdings Inc Pipeline Products & Ongoing Clinical Trials Overview 72

SEA-STAT CNS – Product Status 72

SEA-STAT CNS – Product Description 72

Sealantis Ltd. Pipeline Products & Ongoing Clinical Trials Overview 73

Seal-G – Product Status 73

Seal-G – Product Description 73

Seal-G MIST – Product Status 74

Seal-G MIST – Product Description 74

Sealantis Tissue Adhesive – Product Status 74

Sealantis Tissue Adhesive – Product Description 75

Sealonix Inc Pipeline Products & Ongoing Clinical Trials Overview 76

PramStat Patch – Product Status 76

PramStat Patch – Product Description 76

Selio Medical Pipeline Products & Ongoing Clinical Trials Overview 77

Selio Sealant System – Product Status 77

Selio Sealant System – Product Description 77

Shanghai Haohai Biological Technology Co Ltd Pipeline Products & Ongoing Clinical Trials Overview 78

Fibrin Sealant Powder – Product Status 78

Fibrin Sealant Powder – Product Description 78

Surgical Sealants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 79

Thorex – Product Status 79

Thorex – Product Description 79

Teijin Pharma Ltd Pipeline Products & Ongoing Clinical Trials Overview 80

KTF-374 Fibrin Sealant – Product Status 80

KTF-374 Fibrin Sealant – Product Description 80

Terasaki Institute for Biomedical Innovation Pipeline Products & Ongoing Clinical Trials Overview 81

Gelatin-Based Surgical Sealant – Product Status 81

Gelatin-Based Surgical Sealant – Product Description 81

Tetratherix Pty Ltd Pipeline Products & Ongoing Clinical Trials Overview 82

TrimphSeal – Product Status 82

TrimphSeal – Product Description 82

Texas A&M Engineering Experiment Station Pipeline Products & Ongoing Clinical Trials Overview 83

Biopsy Tract Sealing Device – Product Status 83

Biopsy Tract Sealing Device – Product Description 83

Texas A&M University Pipeline Products & Ongoing Clinical Trials Overview 84

Tissue Welding Device – Product Status 84

Tissue Welding Device – Product Description 84

Wound Healing And Tissue Repair Bandage – Product Status 85

Wound Healing And Tissue Repair Bandage – Product Description 85

The Medicines Co Pipeline Products & Ongoing Clinical Trials Overview 86

Prevent GI Sealant – Product Status 86

Prevent GI Sealant – Product Description 86

Tissium SA Pipeline Products & Ongoing Clinical Trials Overview 87

Drug-Eluting Adhesive – Chronic Rhinosinusitis – Product Status 87

Drug-Eluting Adhesive – Chronic Rhinosinusitis – Product Description 87

SETALUM Sealant – Product Status 88

SETALUM Sealant – Product Description 88

University of Akron Pipeline Products & Ongoing Clinical Trials Overview 89

Wound Closure Glue – Product Status 89

Wound Closure Glue – Product Description 89

Glossary 114

Figures

Tissue Sealants – Pipeline Products by Stage of Development 12_x000D_

Tissue Sealants – Pipeline Products by Segment 13_x000D_

Tissue Sealants – Pipeline Products by Territory 14_x000D_

Tissue Sealants – Pipeline Products by Regulatory Path 15_x000D_

Tissue Sealants – Pipeline Products by Estimated Approval Date 16_x000D_

Tissue Sealants – Ongoing Clinical Trials 17_x000D_

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