Colgate-Palmolive Co (Colgate-Palmolive) is engaged in the manufacture and sale of personal care, oral care, home care, and pet nutrition products. Its products portfolio includes toothpaste, toothbrushes, mouthwashes, pharmaceutical products, hand liquid soap, bar soaps, shower gels, deodorants, antiperspirants, skin health products, hair care products, dishwashing liquids, household cleaners, and fabric conditioners. The company market its products under brands name of Colgate, Darlie, elmex, hello, meridol, Sorriso, Ajax, Axion, Palmolive, Fabuloso, and Suavitel. Colgate-Palmolive's products are marketed in over 200 countries and territories worldwide.

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Colgate-Palmolive’s R&D arm focuses on developing technologically advanced products to meet the oral, personal, home care, and pet nutrition needs of consumers. The company conducts over 200 clinical trials each year to advance technologies that address changing consumer needs in Oral Health, Personal Care, and Premium Skin Health. The company is also involved in open innovation and collaboration with the global startup ecosystem to fulfill its purpose of reimagining a healthier future for all people, their pets, and the planet. The R&D units of Colgate-Palmolive include the primary research and development centers for Oral Care and Personal Care products located in New Jersey, the center for Home Care products in Mexico, and the center for Pet Nutrition products in Kansas. The company holds numerous patents across its product lines, including oral care, skin health, and home care products. It is involved in major technology alliances such as the 100+ Accelerator, which focuses on sustainable innovation in supply chains, and partnerships with Plug and Play to find new ideas and product concepts. In FY2024, the company incurred expenses of US$355 million on R&D, which, as a percentage of revenue, stood at 1.8%.