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Horizon Therapeutics Plc: Segment Analysis

Business Description

Horizon Therapeutics Plc (Horizon Therapeutics) focuses on identifying, developing, acquiring, and commercializing medicines that address unmet medical needs in arthritis, pain, and inflammatory diseases.

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R&D Overview

The R&D efforts of Horizon Therapeutics Plc (Horizon Therapeutics) focus on new and improved pharma and medicine-based innovations. Its R&D strives to develop solutions that improve yield and profitability. The company’s R&D is focused on the development of medicines for therapy areas including rare diseases, autoimmune diseases and severe inflammatory diseases. It operates offices in Canada, Europe, the United States and Japan. The company spent US$431.9 million on R&D in FY2021, which as a percentage of revenue stood at 13.4%.

Business Segments

Overview

It consists of three marketed medicines, including Duexis, Pennsaid 2%, Vimovo and Rayos. Duexis is a proprietary tablet indicated for the treatment of rheumatoid arthritis (RA), osteoarthritis (OA), and to reduce the risk of developing upper gastrointestinal ulcers in people taking ibuprofen for these indications. Pennsaid 2% is a nonsteroidal anti-inflammatory drug for the treatment of pain of osteoarthritis (OA) of the knee(s). Vimovo (naproxen/esomeprazole magnesium) is approved for the treatment of osteoarthritis, RA and ankylosing spondylitis. Rayos is a low-dose drug that is approved for a broad range of diseases. It is an anti-inflammatory or immunosuppressive agent used in the treatment of RA, polymyalgia rheumatic, systemic lupus erythematosus and few other indications.

Performance

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Overview

It consists of Tepezza, Actimmune, Buphenyl, Krystexxa, Procysbi, Quinsair, and Ravicti. Tepezza is used for the treatment of Thyroid Eye Disease (TED). Actimmune is for the treatment of chronic granulomatous disease (CGD) and severe, malignant osteopetrosis. Buphenyl includes tablets for oral administration and powder for oral, nasogastric, or gastrostomy tube administration for the treatment of urea cycle disorders (UCDs). Krystexxa is an orphan biologic medicine, which is the only FDA-approved medicine for chronic refractory gout, a type of arthritis. Procysbi is an approved therapy for the treatment of nephropathic cystinosis. - Quinsair is a formulation of the antibiotic drug levofloxacin that can be inhaled through a nebulizer. - Ravicti is used as a nitrogen-binding agent for the management of chronic adult and pediatric patients aged two years or greater with urea cycle disorders (UCDs) who find it difficult to manage with dietary protein restriction and/or amino acid supplementation alone. It is also used as a dietary supplement.

Performance

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Geographical Segments

Performance

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Performance

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