Charles River Laboratories International Inc - Company Profile
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Business Description
Charles River Laboratories International Inc (Charles River) is a contract research company. The company offers services to pharmaceutical, biotech, government, and academic teams, facilitating the discovery, early-stage development, and safe manufacturing of novel drugs and therapeutics, with a client base that includes major global pharmaceutical companies, biotechnology firms, agricultural and industrial chemical companies, medical device manufacturers, diagnostic and consumer product companies, life science organizations, veterinary medicine entities, contract research and manufacturing organizations, hospitals, academic institutions, and government agencies. The company provides research models and services, insourcing solutions, research animal diagnostic services, cell solutions, discovery services and safety assessment services among others. It offers products and support services essential for the discovery and development of novel treatments targeting therapeutic areas of cardiovascular, central nervous system, metabolic inflammation, oncology, immunology, ophthalmology, and musculoskeletal diseases.
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R&D Overview
Charles River R&D arm focuses on providing foundational tools for drug discovery and development. The company supplies research models, including inbred, outbred, disease, germ-free, and immunodeficient models, and offers services such as genetic testing, vivarium services, and research animal diagnostics. The company also supports the creation and maintenance of genetically engineered models and provides cell solutions for cell therapy development. The R&D units of Charles River include Research Models, Research Model Services, and Cell Solutions. The Research Models unit is responsible for the production and sale of small research models, primarily rodents, which are essential for drug discovery and development. Research Model Services offer flexible solutions to support clients' use of research models, including insourcing solutions, genetically engineered models and services, and research animal diagnostic services. The Cell Solutions unit provides human donor-derived cellular materials for cell therapy development and drug discovery research.
Business Segments
Overview
Offers non-regulated DSA services to support the discovery, development, and regulatory-required safety testing of potential new drugs, which include in vitro and in vivo studies and laboratory support services, especially bioanalytical and strategic non-clinical consulting, and program management. Operates through two business sub-segments: Discovery Services and Safety Assessment. Discovery Services includes streamlining and enhancing drug discovery programs for clients, including expertise and capabilities in all stages of discovery and all major modalities, including small molecules, biologics (antibodies), oligonucleotides, and cell and gene therapies. Also offers integrated drug discovery services, which include target discovery and validation; disease biology; target deconvolution through proteomics and cell microarray technology; hit identification, hit-to-lead progression, and lead optimization; early non-clinical pharmacokinetic and pharmacodynamic studies; appropriate in vivo Discovery Services evaluation; and target engagement and safety biomarker development. Safety Assessment offers studies required for regulatory submission on all therapeutic areas in the pharmaceutical, biotechnology, industrial chemical, agrochemicals, consumer products, veterinary medicines, and medical devices industries. Operates large facilities in Canada, France, the UK, and the US, with additional leased facilities in China and the US. In FY2025, the segment's capital expenditure stood at US$132.9 million, which grew 3.6% YoY.
Performance
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Overview
Operates through two sub-segments: Microbial Solutions and Biologics Solutions. Microbial Solutions provides in vitro lot-release testing products, microbial detection products, and species identification services. Products and services include endotoxin testing, microbial detection and identification kits, reagents, instruments, software, accessories, and laboratory services. Customers include pharmaceutical, biotechnology, medical devices, and consumer products companies. Brands include Endosafe, Celsis, and Accugenix. Biologics Solutions' business is subdivided into two businesses: the Biologics Testing Services business and the CDMO business. Biologics Testing Services offers analytical testing and related capabilities to support the safe manufacture of their biologic drugs and a suite of manufacturing services to produce clients’ advanced therapeutics. CDMO Business offers expertise in gene-modified and unmodified cell therapy manufacturing, coupled with capabilities in viral vector manufacturing, as well as plasma DNA. Operates large, owned properties in the US, Ireland, and China, supplemented by leased facilities in the US, the UK, France, and Germany. In FY2025, the segment's capital expenditure stood at US$41.4 million, which grew 7.5% YoY.
Performance
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Overview
Offers products and services through sub-business segments, including Research Models, Research Model Services, and Cell Solution. Research Models offers commercial production and sale of small research models and supplies large research models. Clients include biotechnology companies, contract research organizations, many government agencies, hospitals, and academic institutions. The models include commonly used laboratory strains, disease models, and specialized strains with compromised immune systems. Small research models include inbred, outbred, hybrid strains, mutant strains, genetically engineered models, and humanized models with biological features. Research Model Services offers maintenance and monitoring of research models and manages research operations for the government entities, academic organizations, and commercial clients through Insourcing Solutions, Genetically Engineered Models and Services (GEMS), and Research Animal Diagnostic Services (RADS). Insourcing Solutions offers colony management to clients’ research operations, including recruitment, training, staffing, and management services within the clients’ facilities and its own vivarium space, utilizing the Charles River Accelerator and Development Lab (CRADL) offerings. GEMS offers contract breeding and other services associated with genetically engineered models. Research Animal Diagnostic Services (RADS) provides health monitoring and diagnostics services related to research models. Cell Solutions provides controlled, consistent, customized primary cells and blood components derived from normal and mobilized peripheral blood and bone marrow, and cells from disease state donors. Operates large facilities in Canada, France, the UK, and the US, with additional leased facilities in China and the US. In FY2025, the segment's capital expenditure stood at US$38.8million, which declined 39.4% YoY.
Performance
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Geographical Segments
Performance
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Performance
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Performance
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Target Markets
Brazil, Israel, and Mauritius.
Performance
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Performance
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